Mouse models of Ebola virus tolerance and lethality: characterization of CD-1 mice infected with wild-type, guinea pig-adapted, or mouse-adapted virus

Spengler, Jessica R.; Welch, Stephen R.; Ritter, Jana M.; Harmon, Jessica R.; Coleman-McCray, JoAnn D.; Genzer, Sarah C.; Seixas, Josilene N.; Scholte, Florine E. M.; Davies, Katherine A.; Bradfute, Steven B.; Montgomery, Joel M.; Spiropoulou, Christina F.

doi:10.1016/j.antiviral.2022.105496

Title: Mouse models of Ebola virus tolerance and lethality: characterization of CD-1 mice infected with wild-type, guinea pig-adapted, or mouse-adapted virus

Journal Article · Wed Feb 01 00:00:00 EST 2023 · Antiviral Research

DOI:https://doi.org/10.1016/j.antiviral.2022.105496· OSTI ID:1960853

; Welch, Stephen R.; Ritter, Jana M.; Harmon, Jessica R.; Coleman-McCray, JoAnn D.; Genzer, Sarah C.; Seixas, Josilene N.; Scholte, Florine E. M.; Davies, Katherine A.; Bradfute, Steven B.; Montgomery, Joel M.; Spiropoulou, Christina F.

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Sponsoring Organization:: USDOE

OSTI ID:: 1960853

Journal Information:: Antiviral Research, Journal Name: Antiviral Research Vol. 210 Journal Issue: C; ISSN 0166-3542

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

References (42)

Virus-Like Particles Activate Type I Interferon Pathways to Facilitate Post-Exposure Protection against Ebola Virus Infection Ayithan, Natarajan; Bradfute, Steven B.; Anthony, Scott M. PLOS ONE, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pone.0118345	journal	February 2015
Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective Fisicaro, Francesco; Di Napoli, Mario; Liberto, Aldo International Journal of Environmental Research and Public Health, Vol. 18, Issue 4 https://doi.org/10.3390/ijerph18041415	journal	February 2021
Pathogenesis of Experimental Ebola Virus Infection in Guinea Pigs Connolly, Brett M.; Steele, Keith E.; Davis, Kelly J. The Journal of Infectious Diseases, Vol. 179, Issue s1 https://doi.org/10.1086/514305	journal	February 1999
Interferon α/β Receptor–Deficient Mice as a Model for Ebola Virus Disease Brannan, Jennifer M.; Froude, Jeffery W.; Prugar, Laura I. Journal of Infectious Diseases, Vol. 212, Issue suppl 2 https://doi.org/10.1093/infdis/jiv215	journal	May 2015
Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings Muehlenbachs, Atis; de la Rosa Vázquez, Olimpia; Bausch, Daniel G. Journal of Infectious Diseases, Vol. 215, Issue 1 https://doi.org/10.1093/infdis/jiw206	journal	May 2016
Molecular Characterization of Guinea Pig-Adapted Variants of Ebola Virus Volchkov, Viktor E.; Chepurnov, Aleksandr A.; Volchkova, Valentina A. Virology, Vol. 277, Issue 1 https://doi.org/10.1006/viro.2000.0572	journal	November 2000
Disease modeling for Ebola and Marburg viruses Bente, D.; Gren, J.; Strong, J. E. Disease Models and Mechanisms, Vol. 2, Issue 1-2 https://doi.org/10.1242/dmm.000471	journal	January 2009
Early immune responses accompanying human asymptomatic Ebola infections Leroy, E. M.; Baize, S.; Debre, P. Clinical and Experimental Immunology, Vol. 124, Issue 3 https://doi.org/10.1046/j.1365-2249.2001.01517.x	journal	December 2001
Immune barriers of Ebola virus infection McElroy, Anita K.; Mühlberger, Elke; Muñoz-Fontela, César Current Opinion in Virology, Vol. 28 https://doi.org/10.1016/j.coviro.2018.01.010	journal	February 2018
Understanding long-term effects of Ebola virus disease Chertow, Daniel S. Nature Medicine, Vol. 25, Issue 5 https://doi.org/10.1038/s41591-019-0444-0	journal	April 2019
Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus Liu, Xuan; Speranza, Emily; Muñoz-Fontela, César Genome Biology, Vol. 18, Issue 1 https://doi.org/10.1186/s13059-016-1137-3	journal	January 2017
Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1 McElroy, Anita K.; Shrivastava-Ranjan, Punya; Harmon, Jessica R. Emerging Infectious Diseases, Vol. 25, Issue 2 https://doi.org/10.3201/eid2502.181326	journal	February 2019
Genetic factors of Ebola virus virulence in guinea pigs Subbotina, Ekaterina; Dadaeva, Alexandra; Kachko, Alla Virus Research, Vol. 153, Issue 1 https://doi.org/10.1016/j.virusres.2010.07.015	journal	October 2010
The role of the Type I interferon response in the resistance of mice to filovirus infection Bray, Mike Journal of General Virology, Vol. 82, Issue 6 https://doi.org/10.1099/0022-1317-82-6-1365	journal	June 2001
Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone Howlett, Patrick J.; Walder, Anna R.; Lisk, Durodami R. Emerging Infectious Diseases, Vol. 24, Issue 8 https://doi.org/10.3201/eid2408.171367	journal	August 2018
Long-term Complications of Ebola Virus Disease: Prevalence and Predictors of Major Symptoms and the Role of Inflammation Tozay, Sam; Fischer, William A.; Wohl, David A. Clinical Infectious Diseases, Vol. 71, Issue 7 https://doi.org/10.1093/cid/ciz1062	journal	November 2019
Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery Panchal, Rekha G.; Mourich, Dan V.; Bradfute, Steven Nucleic Acid Therapeutics, Vol. 24, Issue 3 https://doi.org/10.1089/nat.2013.0457	journal	June 2014
Mechanisms of Immunity in Post-Exposure Vaccination against Ebola Virus Infection Bradfute, Steven B.; Anthony, Scott M.; Stuthman, Kelly S. PLOS ONE, Vol. 10, Issue 3 https://doi.org/10.1371/journal.pone.0118434	journal	March 2015
Development and Characterization of a Guinea Pig-Adapted Sudan Virus Wong, Gary; He, Shihua; Wei, Haiyan Journal of Virology, Vol. 90, Issue 1 https://doi.org/10.1128/JVI.02331-15	journal	January 2016
Animal models for ebolavirus countermeasures discovery: what defines a useful model? Shurtleff, Amy C.; Bavari, Sina Expert Opinion on Drug Discovery, Vol. 10, Issue 7 https://doi.org/10.1517/17460441.2015.1035252	journal	May 2015
Immune and pathophysiological processes in baboons experimentally infected with Ebola virus adapted to guinea pigs Ignatiev, George M.; Dadaeva, Alexandra A.; Luchko, Sergey V. Immunology Letters, Vol. 71, Issue 2 https://doi.org/10.1016/S0165-2478(99)00169-8	journal	February 2000
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance Rasmussen, Angela L.; Okumura, Atsushi; Ferris, Martin T. Science, Vol. 346, Issue 6212 https://doi.org/10.1126/science.1259595	journal	November 2014
Haematological, Biochemical and Coagulation Changes in Mice, Guinea-pigs and Monkeys Infected with a Mouse-adapted Variant of Ebola Zaire Virus Bray, M.; Hatfill, S.; Hensley, L. Journal of Comparative Pathology, Vol. 125, Issue 4 https://doi.org/10.1053/jcpa.2001.0503	journal	November 2001
Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections Hirschenberger, Maximilian; Hunszinger, Victoria; Sparrer, Konstantin Maria Johannes Cells, Vol. 10, Issue 8 https://doi.org/10.3390/cells10082134	journal	August 2021
Utility of Oral Swab Sampling for Ebola Virus Detection in Guinea Pig Model Spengler, Jessica R.; Chakrabarti, Ayan K.; Coleman-McCray, JoAnn D. Emerging Infectious Diseases, Vol. 21, Issue 10 https://doi.org/10.3201/eid2110.150840	journal	October 2015
Pathogenesis of Experimental Ebola Zaire Virus Infection in BALB/c Mice Gibb, T. R.; Bray, M.; Geisbert, T. W. Journal of Comparative Pathology, Vol. 125, Issue 4 https://doi.org/10.1053/jcpa.2001.0502	journal	November 2001
Animal models of viral hemorrhagic fever Smith, Darci R.; Holbrook, Michael R.; Gowen, Brian B. Antiviral Research, Vol. 112 https://doi.org/10.1016/j.antiviral.2014.10.001	journal	December 2014
A Novel Immunohistochemical Assay for the Detection of Ebola Virus in Skin: Implications for Diagnosis, Spread, and Surveillance of Ebola Hemorrhagic Fever Zaki, Sherif R.; Shieh, Wun‐Ju; Greer, Patricia W. The Journal of Infectious Diseases, Vol. 179, Issue s1 https://doi.org/10.1086/514319	journal	February 1999
Characterization of Ebola Virus–Associated Eye Disease Eghrari, Allen O.; Bishop, Rachel J.; Ross, Robin D. JAMA Network Open, Vol. 4, Issue 1 https://doi.org/10.1001/jamanetworkopen.2020.32216	journal	January 2021
Reduced Levels of Protein Tyrosine Phosphatase CD45 Protect Mice from the Lethal Effects of Ebola Virus Infection Panchal, Rekha G.; Bradfute, Steven B.; Peyser, Brian D. Cell Host & Microbe, Vol. 6, Issue 2 https://doi.org/10.1016/j.chom.2009.07.003	journal	August 2009
Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver Spengler, Jessica R.; Saturday, Greg; Lavender, Kerry J. The Journal of Infectious Diseases, Vol. 217, Issue 1 https://doi.org/10.1093/infdis/jix562	journal	October 2017
Development of a Well-Characterized Rhesus Macaque Model of Ebola Virus Disease for Support of Product Development Alfson, Kendra J.; Goez-Gazi, Yenny; Gazi, Michal Microorganisms, Vol. 9, Issue 3 https://doi.org/10.3390/microorganisms9030489	journal	February 2021
Immunobiology of Ebola and Lassa virus infections Prescott, Joseph B.; Marzi, Andrea; Safronetz, David Nature Reviews Immunology, Vol. 17, Issue 3 https://doi.org/10.1038/nri.2016.138	journal	January 2017
Experimental Inoculation of Plants and Animals with Ebola Virus Swanepoel, Robert Emerging Infectious Diseases, Vol. 2, Issue 4 https://doi.org/10.3201/eid0204.960407	journal	December 1996
Human asymptomatic Ebola infection and strong inflammatory response Leroy, Em; Baize, S.; Volchkov, Ve The Lancet, Vol. 355, Issue 9222 https://doi.org/10.1016/S0140-6736(00)02405-3	journal	June 2000
Development of a model for marburgvirus based on severe-combined immunodeficiency mice Warfield, Kelly L.; Alves, Derron A.; Bradfute, Steven B. Virology Journal, Vol. 4, Issue 1 https://doi.org/10.1186/1743-422X-4-108	journal	January 2007
Clinical sequelae among individuals with pauci-symptomatic or asymptomatic Ebola virus infection and unrecognised Ebola virus disease in Liberia: a longitudinal cohort study Kelly, J. Daniel; Van Ryn, Collin; Badio, Moses The Lancet Infectious Diseases, Vol. 22, Issue 8 https://doi.org/10.1016/S1473-3099(22)00127-X	journal	August 2022
Infection of epididymal epithelial cells and leukocytes drives seminal shedding of Zika virus in a mouse model McDonald, Erin M.; Duggal, Nisha K.; Ritter, Jana M. PLOS Neglected Tropical Diseases, Vol. 12, Issue 8 https://doi.org/10.1371/journal.pntd.0006691	journal	August 2018
A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever Bray, Mike; Davis, Kelly; Geisbert, Tom The Journal of Infectious Diseases, Vol. 178, Issue 3 https://doi.org/10.1086/515386	journal	September 1998
Inhibition of Ebola virus by S-adenosylhomocysteine hydrolase inhibitors Huggins, J. W.; Zhang, Z. X.; Davis, Kelly Antiviral Research, Vol. 26, Issue 3 https://doi.org/10.1016/0166-3542(95)94839-T	journal	March 1995
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model Oestereich, Lisa; Lüdtke, Anja; Wurr, Stephanie Antiviral Research, Vol. 105 https://doi.org/10.1016/j.antiviral.2014.02.014	journal	May 2014
Clinical, virological, and biological parameters associated with outcomes of Ebola virus infection in Macenta, Guinea Vernet, Marie-Astrid; Reynard, Stéphanie; Fizet, Alexandra JCI Insight, Vol. 2, Issue 6 https://doi.org/10.1172/jci.insight.88864	journal	March 2017

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