Circadian rhythmicity of amyloid‐beta‐related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model

Furtado, André; Esgalhado, André J.; Duarte, Ana C.; Costa, Ana R.; Costa‐Brito, Ana R.; Carro, Eva; Ishikawa, Hiroshi; Schroten, Horst; Schwerk, Christian; Gonçalves, Isabel; Arosa, Fernando A.; Santos, Cecília R. A.; Quintela, Telma

doi:10.1002/jnr.25164

Title: Circadian rhythmicity of amyloid‐beta‐related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model

Journal Article · Fri Dec 30 00:00:00 EST 2022 · Journal of Neuroscience Research

DOI:https://doi.org/10.1002/jnr.25164· OSTI ID:1924808

Furtado, André ^[1]; Esgalhado, André J. ^[1];

^[2]; Costa, Ana R. ^[1]; Costa‐Brito, Ana R. ^[1]; Carro, Eva ^[3]; Ishikawa, Hiroshi ^[4]; Schroten, Horst ^[5];

^[5]; Gonçalves, Isabel ^[1];

^[1]; Santos, Cecília R. A. ^[1]; Quintela, Telma ^[2]

CICS‐UBI, Health Sciences Research Centre, University of Beira Interior Covilhã Portugal
CICS‐UBI, Health Sciences Research Centre, University of Beira Interior Covilhã Portugal, UDI‐IPG‐ Unidade de Investigação para o Desenvolvimento do Interior Instituto Politécnico da Guarda Guarda Portugal
Networked Biomedical Research Center in Neurodegenerative Diseases (CIBERNED) Madrid Spain, Group of Neurodegenerative Diseases Hospital 12 de Octubre Research Institute (imas12) Madrid Spain
Laboratory of Clinical Regenerative Medicine, Department of Neurosurgery, Faculty of Medicine University of Tsukuba Tsukuba Japan
Mannheim Medical Faculty University of Heidelberg, Childrens Hospital Mannheim Germany

Abstract The choroid plexus (CP) is part of the blood‐cerebrospinal fluid barrier (BCSFB) and was recently described as an important component of the circadian clock system. It is the principal source of cerebrospinal fluid (CSF) and responsible for the synthesis and secretion of various neuroprotective peptides including those involved in amyloid‐β (Aβ) transport/degradation, contributing to Aβ homeostasis. Inadequate Aβ metabolic clearance and transport across the BCSFB have been associated with circadian dysfunctions in Alzheimer's disease (AD) patients. To investigate whether AD pathology influences Aβ scavengers circadian expression, we collected CP at different time points from an AD mouse model (APP/PS1) (female and male animals, aged 6‐ and 12‐months‐old) and analyzed their mRNA expression by Real‐time RT‐PCR. Only angiotensin‐converting enzyme (Ace) expression in 6‐month‐old female wild‐type mice and transthyretin (Ttr) expression in 12‐month‐old female wild‐type mice presented significant rhythmicity. The circadian rhythmicity of Ace and Ttr, prompt us to analyze the involvement of circadian rhythm in Aβ uptake. A human CP papilloma (HIBCPP) cell line was incubated with Aβ‐488 and uptake was evaluated at different time points using flow cytometry. Aβ uptake displayed circadian rhythmicity. Our results suggest that AD might affect Aβ scavengers rhythmicity and that Aβ clearance is a rhythmic process possibly regulated by the rhythmic expression of Aβ scavengers.

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Sponsoring Organization:: USDOE

OSTI ID:: 1924808

Journal Information:: Journal of Neuroscience Research, Journal Name: Journal of Neuroscience Research Vol. 101 Journal Issue: 4; ISSN 0360-4012

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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