High purity 47Sc production using high-energy photons and natural vanadium targets

Snow, Mathew S.; Foley, Ariana A.; Ward, Jessica L.; Kinlaw, Mathew T.; Stoner, Jon; Carney, Kevin P.

doi:10.1016/j.apradiso.2021.109934

High purity ⁴⁷Sc production using high-energy photons and natural vanadium targets

Journal Article · Sat Sep 04 00:00:00 EDT 2021 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2021.109934· OSTI ID:1923052

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Idaho National Laboratory (INL), Idaho Falls, ID (United States)
Idaho Accelerator Center, Pocatello, ID (United States)

We report Scandium-47 (⁴⁷Sc) is of high value for targeted radiotherapy and theranostics; we report a novel, cost-effective approach to produce extremely high-purity ⁴⁷Sc via photonuclear irradiation of natural vanadium. Irradiations at bremsstrahlung end-point energies below 26 and at 38 MeV produce > 99.99% and 98.8 ± 3.1% pure ⁴⁷Sc (respectively). Linear scaling of experimental data suggests producing 100+ mCi quantities of ⁴⁷Sc may be feasible via this approach. Future research into refinement and scale-up to support pre-clinical and clinical research with this production pathway is recommended.

View Accepted Manuscript (DOE)

Research Organization:: Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE Office of Nuclear Energy (NE)

Grant/Contract Number:: AC07-05ID14517

OSTI ID:: 1923052

Report Number(s):: INL/JOU-20-58753

Journal Information:: Applied Radiation and Isotopes, Journal Name: Applied Radiation and Isotopes Journal Issue: - Vol. 178; ISSN 0969-8043

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (24)

Practical Gamma-Ray Spectrometry Gilmore, Gordon R. https://doi.org/10.1002/9780470861981	book	April 2008
Stability of 47Sc-complexes with acyclic polyamino-polycarboxylate ligands Połosak, Magdalena; Piotrowska, Agata; Krajewski, Seweryn Journal of Radioanalytical and Nuclear Chemistry, Vol. 295, Issue 3 https://doi.org/10.1007/s10967-012-2188-x	journal	September 2012
Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc Starovoitova, Valeriia N.; Cole, Philip L.; Grimm, Terry L. Journal of Radioanalytical and Nuclear Chemistry, Vol. 305, Issue 1 https://doi.org/10.1007/s10967-015-4039-z	journal	March 2015
47Sc production development by cyclotron irradiation of 48Ca Misiak, R.; Walczak, R.; Wąs, B. Journal of Radioanalytical and Nuclear Chemistry, Vol. 313, Issue 2 https://doi.org/10.1007/s10967-017-5321-z	journal	June 2017
New developments in the production of theranostic pairs of radionuclides Qaim, Syed M.; Scholten, Bernhard; Neumaier, Bernd Journal of Radioanalytical and Nuclear Chemistry, Vol. 318, Issue 3 https://doi.org/10.1007/s10967-018-6238-x	journal	October 2018
Theranostic radionuclides: recent advances in production methodologies Qaim, Syed M. Journal of Radioanalytical and Nuclear Chemistry, Vol. 322, Issue 3 https://doi.org/10.1007/s10967-019-06797-y	journal	September 2019
Production of 47Sc with natural vanadium targets: results of the PASTA project Pupillo, Gaia; Mou, Liliana; Boschi, Alessandra Journal of Radioanalytical and Nuclear Chemistry, Vol. 322, Issue 3 https://doi.org/10.1007/s10967-019-06844-8	journal	October 2019
Preparation of carrier-free 47Sc by the 48Ti (γ,p) reaction Yagi, Masuo; Kondo, Kenjiro The International Journal of Applied Radiation and Isotopes, Vol. 28, Issue 5 https://doi.org/10.1016/0020-708X(77)90178-8	journal	May 1977
Radionuclide development at BNL for nuclear medicine therapy Mausner, L. F.; Kolsky, K. L.; Joshi, V. Applied Radiation and Isotopes, Vol. 49, Issue 4 https://doi.org/10.1016/S0969-8043(97)00040-7	journal	April 1998
Radiochemical purification of no-carrier-added scandium-47 for radioimmunotherapy Kolsky, K. L.; Joshi, V.; Mausner, L. F. Applied Radiation and Isotopes, Vol. 49, Issue 12 https://doi.org/10.1016/S0969-8043(98)00016-5	journal	December 1998
Investigations of the natTi(p,x)43,44m,44g,46,47,48Sc,48V nuclear processes up to 40MeV Khandaker, M. U.; Kim, K.; Lee, M. W. Applied Radiation and Isotopes, Vol. 67, Issue 7-8 https://doi.org/10.1016/j.apradiso.2009.02.030	journal	July 2009
47Ca production for 47Ca/47Sc generator system using electron linacs Rane, Shraddha; Harris, Jason T.; Starovoitova, Valeriia N. Applied Radiation and Isotopes, Vol. 97 https://doi.org/10.1016/j.apradiso.2014.12.020	journal	March 2015
Sc-47 production from titanium targets using electron linacs Mamtimin, Mayir; Harmon, Frank; Starovoitova, Valeriia N. Applied Radiation and Isotopes, Vol. 102 https://doi.org/10.1016/j.apradiso.2015.04.012	journal	August 2015
Production of scandium-43 and -47 from a powdery calcium oxide target via the nat/44Ca(α,x)-channel Minegishi, Katsuyuki; Nagatsu, Kotaro; Fukada, Masami Applied Radiation and Isotopes, Vol. 116 https://doi.org/10.1016/j.apradiso.2016.07.017	journal	October 2016
Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets Rotsch, David A.; Brown, M. Alex; Nolen, Jerry A. Applied Radiation and Isotopes, Vol. 131 https://doi.org/10.1016/j.apradiso.2017.11.007	journal	January 2018
Investigations of proton and deuteron induced nuclear reactions on natural and enriched Titanium, Calcium and Vanadium targets, with special reference to the production of 47Sc Jafari, Ali; Aboudzadeh, Mohammad Reza; Azizakram, Hamid Applied Radiation and Isotopes, Vol. 152 https://doi.org/10.1016/j.apradiso.2019.07.007	journal	October 2019
ENDF/B-VIII.0: The 8 th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data Brown, D. A.; Chadwick, M. B.; Capote, R. Nuclear Data Sheets, Vol. 148 https://doi.org/10.1016/j.nds.2018.02.001	journal	February 2018
Paving the Way to Personalized Medicine: Production of Some Promising Theragnostic Radionuclides at Brookhaven National Laboratory Srivastava, Suresh C. Seminars in Nuclear Medicine, Vol. 42, Issue 3 https://doi.org/10.1053/j.semnuclmed.2011.12.004	journal	May 2012
Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc Loveless, C. Shaun; Radford, Lauren L.; Ferran, Samuel J. EJNMMI Research, Vol. 9, Issue 1 https://doi.org/10.1186/s13550-019-0515-8	journal	May 2019
47Sc as useful β–-emitter for the radiotheragnostic paradigm: a comparative study of feasible production routes Domnanich, Katharina A.; Müller, Cristina; Benešová, Martina EJNMMI Radiopharmacy and Chemistry, Vol. 2, Issue 1 https://doi.org/10.1186/s41181-017-0024-x	journal	June 2017
Paving the way to personalized medicine: production of some theragnostic radionuclides at Brookhaven National Laboratory Srivastava, Suresh C. Radiochimica Acta, Vol. 99, Issue 10 https://doi.org/10.1524/ract.2011.1882	journal	October 2011
Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice Muller, C.; Bunka, M.; Haller, S. Journal of Nuclear Medicine, Vol. 55, Issue 10 https://doi.org/10.2967/jnumed.114.141614	journal	July 2014
THERANOSTICS: From Molecular Imaging Using Ga-68 Labeled Tracers and PET/CT to Personalized Radionuclide Therapy - The Bad Berka Experience Baum, Richard P.; Kulkarni, Harshad R. Theranostics, Vol. 2, Issue 5 https://doi.org/10.7150/thno.3645	journal	January 2012
Molecular Imaging and Radiotherapy: Theranostics for Personalized Patient Management Velikyan, Irina Theranostics, Vol. 2, Issue 5 https://doi.org/10.7150/thno.4428	journal	January 2012

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High purity 47Sc production using high-energy photons and natural vanadium targets

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High purity ⁴⁷Sc production using high-energy photons and natural vanadium targets