Development of a physiologically based test to estimate the bioavailability of inorganic elements in soil
Conference
·
OSTI ID:191282
- PTI Environmental Services, Boulder, CO (United States)
A physiologically based bioaccessibility test (PBBT) that mimics gastrointestinal (GI) tract function and chemistry has been developed to estimate the bioavailability of inorganic elements in soil, and to justify revised soil remediation goals based on adjustment for the bioavailability of inorganic elements in ingested soil. The test incorporates GI tract parameters representative of a human, including stomach and small intestinal pH, soil-to-solution ratio, stomach mixing, stomach emptying rate, and small intestinal transit time. In addition to providing mechanistic data on factors controlling the bioaccessibility of inorganic elements, the PBBT closely approximates bioavailability study results in animal models. To date, the PBBT has been validated against lead and cadmium bioavailability studies in Sprague-Dawley rats, and arsenic bioavailability studies in New Zealand White rabbits and Cynomolgus monkeys. PBBT data have been used to develop revised soil arsenic remediation goals in Oklahoma and Michigan, which have been accepted by State regulatory agencies. The PBBT is currently under validation for additional inorganic elements (e.g., beryllium, chromium, and vanadium) and is being redesigned to address organic contaminants in soil (e.g., weathered petroleum hydrocarbons, PAHs).
- OSTI ID:
- 191282
- Report Number(s):
- CONF-9511137--; ISBN 1-880611-03-1
- Country of Publication:
- United States
- Language:
- English
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