Plant Biosystems Design Research Roadmap 1.0

Yang, Xiaohan; Medford, June I.; Markel, Kasey; Shih, Patrick M.; De Paoli, Henrique C.; Trinh, Cong T.; McCormick, Alistair J.; Ployet, Raphael; Hussey, Steven G.; Myburg, Alexander A.; Jensen, Poul Erik; Hassan, Md Mahmudul; Zhang, Jin; Muchero, Wellington; Kalluri, Udaya C.; Yin, Hengfu; Zhuo, Renying; Abraham, Paul E.; Chen, Jin-Gui; Weston, David J.; Yang, Yinong; Liu, Degao; Li, Yi; Labbe, Jessy; Yang, Bing; Lee, Jun Hyung; Cottingham, Robert W.; Martin, Stanton; Lu, Mengzhu; Tschaplinski, Timothy J.; Yuan, Guoliang; Lu, Haiwei; Ranjan, Priya; Mitchell, Julie C.; Wullschleger, Stan D.; Tuskan, Gerald A.

doi:10.34133/2020/8051764

Title: Plant Biosystems Design Research Roadmap 1.0

Journal Article · Sat Dec 05 00:00:00 EST 2020 · BioDesign Research

DOI:https://doi.org/10.34133/2020/8051764· OSTI ID:1909245

^[1]; Medford, June I. ^[2]; Markel, Kasey ^[3];

^[4]; De Paoli, Henrique C. ^[5]; Trinh, Cong T. ^[6]; McCormick, Alistair J. ^[7]; Ployet, Raphael ^[8]; Hussey, Steven G. ^[8]; Myburg, Alexander A. ^[8]; Jensen, Poul Erik ^[9]; Hassan, Md Mahmudul ^[1]; Zhang, Jin ^[10]; Muchero, Wellington ^[1];

^[1]; Yin, Hengfu ^[11]; Zhuo, Renying ^[11];

^[1];

^[1]; Weston, David J. ^[1] more »

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA, The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
Department of Plant Biology, University of California, Davis, Davis, CA, USA
Department of Plant Biology, University of California, Davis, Davis, CA, USA, Feedstocks Division, Joint BioEnergy Institute, Emeryville, CA, USA
Department of Biodesign, Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA, Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996, USA
SynthSys and Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK
Department of Biochemistry, Genetics and Microbiology, Forestry and Agricultural Biotechnology Institute (FABI), University of Pretoria, Pretoria 0002, South Africa
Department of Food Science, University of Copenhagen, Rolighedsvej 26, DK-1858, Frederiksberg, Copenhagen, Denmark
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA, The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA, State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&,F University, Hangzhou, Zhejiang 311300, China
State Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou, Zhejiang 311400, China
Department of Plant Pathology and Environmental Microbiology and the Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Department of Genetics, Cell Biology and Development, Center for Precision Plant Genomics and Center for Genome Engineering, University of Minnesota, Saint Paul, MN 55108, USA
Department of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA
Division of Plant Sciences, Bond Life Sciences Center, University of Missouri, Columbia, MO, USA, Donald Danforth Plant Science Center, St. Louis, MO, USA
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&,F University, Hangzhou, Zhejiang 311300, China
Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA

Human life intimately depends on plants for food, biomaterials, health, energy, and a sustainable environment. Various plants have been genetically improved mostly through breeding, along with limited modification via genetic engineering, yet they are still not able to meet the ever-increasing needs, in terms of both quantity and quality, resulting from the rapid increase in world population and expected standards of living. A step change that may address these challenges would be to expand the potential of plants using biosystems design approaches. This represents a shift in plant science research from relatively simple trial-and-error approaches to innovative strategies based on predictive models of biological systems. Plant biosystems design seeks to accelerate plant genetic improvement using genome editing and genetic circuit engineering or create novel plant systems through de novo synthesis of plant genomes. From this perspective, we present a comprehensive roadmap of plant biosystems design covering theories, principles, and technical methods, along with potential applications in basic and applied plant biology research. We highlight current challenges, future opportunities, and research priorities, along with a framework for international collaboration, towards rapid advancement of this emerging interdisciplinary area of research. Finally, we discuss the importance of social responsibility in utilizing plant biosystems design and suggest strategies for improving public perception, trust, and acceptance.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Univ. of Tennessee, Knoxville, TN (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program; National Science Foundation (NSF); USDA; Chinese Academy of Forestry; UK Biotechnology and Biological Sciences Research Council; Leverhulme Trust; USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231; 1553250; AC05-00OR22725; SC0019412; 1740874; 1833402; PEN04659; 1016432; CAFYBB2018ZY001; BB/M006468/1; BB/S015531/1; RPG-2017-402

OSTI ID:: 1909245

Alternate ID(s):: OSTI ID: 1737481; OSTI ID: 1777840

Journal Information:: BioDesign Research, Journal Name: BioDesign Research Vol. 2020; ISSN 2693-1257

Publisher:: American Association for the Advancement of Science (AAAS)Copyright Statement

Country of Publication:: India

Language:: English

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