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Preliminary investigation of 48V-labeled VO(acac)2 for cancer imaging: An initial proof-of-concept study

Journal Article · · Applied Radiation and Isotopes
 [1];  [1];  [1];  [1];  [1];  [1];  [2];  [1]
  1. University of Chicago, IL (United States)
  2. University of Chicago, IL (United States); Argonne National Laboratory (ANL), Lemont, IL (United States)
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In this preliminary study, a procedure for synthesizing novel PET radiotracer vanadium-48-labeled-vanadyl acetylacetonate was developed, including radioisotope production via cyclotron, separation of 48V, chelation as 48VO(acac)2, and assessment through in vitro cellular studies. We employed the beam-stop setup in a cyclotron as the target holder to irradiate titanium foils in the reaction of natTi (p,n)48V. The radioisotope production rate was 4.84 ± 0.67 μCi/μA-h. Overall radiochemical yield was 12.86 ± 0.51% with gamma-ray spectroscopy showing no detectable contaminant peaks. HPLC of 48VO(acac)2 showed a retention time (1:48) corresponding closely to that (1:50) of commercial VO(acac)2, verifying the successful synthesis of 8VO(acac)2. In vitro cellular studies demonstrated radiotracer uptake and saturation around 0.48 nM. These studies pave the way for improving methodologies and in vivo experiments, including imaging studies, in future investigations.
Research Organization:
Argonne National Laboratory (ANL), Lemont, IL (United States)
Sponsoring Organization:
National Institutes of Health (NIH); University of Chicago
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1909013
Journal Information:
Applied Radiation and Isotopes, Journal Name: Applied Radiation and Isotopes Vol. 186; ISSN 0969-8043
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

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62 RADIOLOGY AND NUCLEAR MEDICINE
nuclear medicine
positron emission tomography
vanadium-48
vanadyl acetylacetonate