Molecular Pathogenesis and Immune Evasion of Vesicular Stomatitis New Jersey Virus Inferred from Genes Expression Changes in Infected Porcine Macrophages

Velazquez-Salinas, Lauro; Canter, Jessica A.; Zhu, James J.; Rodriguez, Luis L.

doi:10.3390/pathogens10091134

Molecular Pathogenesis and Immune Evasion of Vesicular Stomatitis New Jersey Virus Inferred from Genes Expression Changes in Infected Porcine Macrophages

Journal Article · Fri Sep 03 00:00:00 EDT 2021 · Pathogens

DOI:https://doi.org/10.3390/pathogens10091134· OSTI ID:1904965

Velazquez-Salinas, Lauro ^[1]; Canter, Jessica A. ^[2]; Zhu, James J. ^[3]; ^[3]

US Dept. of Agriculture (USDA), Greenport, NY (United States). ARS-Plum Island Animal Disease Center; Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States); OSTI
US Dept. of Agriculture (USDA), Greenport, NY (United States). ARS-Plum Island Animal Disease Center; Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
US Dept. of Agriculture (USDA), Greenport, NY (United States). ARS-Plum Island Animal Disease Center

The molecular mechanisms associated with the pathogenesis of vesicular stomatitis virus (VSV) in livestock remain poorly understood. Several studies have highlighted the relevant role of macrophages in controlling the systemic dissemination of VSV during infection in different animal models, including mice, cattle, and pigs. To gain more insight into the molecular mechanisms used by VSV to impair the immune response in macrophages, we used microarrays to determine the transcriptomic changes produced by VSV infection in primary cultures of porcine macrophages. The results indicated that VSV infection induced the massive expression of multiple anorexic, pyrogenic, proinflammatory, and immunosuppressive genes. Overall, the interferon (IFN) response appeared to be suppressed, leading to the absence of stimulation of interferon-stimulated genes (ISG). Interestingly, VSV infection promoted the expression of several genes known to downregulate the expression of IFNβ. This represents an alternate mechanism for VSV control of the IFN response, beyond the recognized mechanisms mediated by the matrix protein. Although there was no significant differential gene expression in macrophages infected with a highly virulent epidemic strain compared to a less virulent endemic strain, the endemic strain consistently induced higher expression of all upregulated cytokines and chemokines. Collectively, this study provides novel insights into VSV molecular pathogenesis and immune evasion that warrant further investigation.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDA; USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 1904965

Journal Information:: Pathogens, Journal Name: Pathogens Journal Issue: 9 Vol. 10; ISSN 2076-0817

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy Singh, Pratibha; Ravanan, Palaniyandi; Talwar, Priti Frontiers in Molecular Neuroscience, Vol. 9 https://doi.org/10.3389/fnmol.2016.00046	journal	June 2016
Prostaglandin E2 As a Modulator of Viral Infections Sander, Willem J.; O'Neill, Hester G.; Pohl, Carolina H. Frontiers in Physiology, Vol. 8 https://doi.org/10.3389/fphys.2017.00089	journal	February 2017
Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review Önal, Uğur; Valenzuela-Sánchez, Francisco; Vandana, Kalwaje Healthcare, Vol. 6, Issue 3 https://doi.org/10.3390/healthcare6030110	journal	September 2018
Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b Morgan, Niamh E.; Cutrona, Meritxell B.; Simpson, Jeremy C. International Journal of Molecular Sciences, Vol. 20, Issue 16 https://doi.org/10.3390/ijms20163916	journal	August 2019
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Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10 Schaljo, Barbara; Kratochvill, Franz; Gratz, Nina The Journal of Immunology, Vol. 183, Issue 2 https://doi.org/10.4049/jimmunol.0803883	journal	June 2009
Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1β Production Mielke, Lisa A.; Elkins, Karen L.; Wei, Lai The Journal of Immunology, Vol. 183, Issue 12 https://doi.org/10.4049/jimmunol.0901336	journal	November 2009
IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1 Liu, Xin-Yi; Chen, Wei; Wei, Bo The Journal of Immunology, Vol. 187, Issue 5 https://doi.org/10.4049/jimmunol.1100963	journal	August 2011
Regulation of Immune Responses by Prostaglandin E ₂ Kalinski, Pawel The Journal of Immunology, Vol. 188, Issue 1 https://doi.org/10.4049/jimmunol.1101029	journal	December 2011
Extracellular UDP and P2Y₆Function as a Danger Signal To Protect Mice from Vesicular Stomatitis Virus Infection through an Increase in IFN-β Production Li, Ruimei; Tan, Binghe; Yan, Yan The Journal of Immunology, Vol. 193, Issue 9 https://doi.org/10.4049/jimmunol.1301930	journal	September 2014
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59 BASIC BIOLOGICAL SCIENCES
Microbiology
differential gene expression
immune evasion
macrophage
microarray analysis
molecular pathogenesis
vesicular stomatitis virus

Molecular Pathogenesis and Immune Evasion of Vesicular Stomatitis New Jersey Virus Inferred from Genes Expression Changes in Infected Porcine Macrophages

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