An Overview of Biofilm Formation–Combating Strategies and Mechanisms of Action of Antibiofilm Agents

Asma, Syeda Tasmia; Imre, Kálmán; Morar, Adriana; Herman, Viorel; Acaroz, Ulas; Mukhtar, Hamid; Arslan-Acaroz, Damla; Shah, Syed Rizwan Ali; Gerlach, Robin

doi:10.3390/life12081110

An Overview of Biofilm Formation–Combating Strategies and Mechanisms of Action of Antibiofilm Agents

Journal Article · Sat Jul 23 00:00:00 EDT 2022 · Life

DOI:https://doi.org/10.3390/life12081110· OSTI ID:1904777

^[1]; Imre, Kálmán ^[2]; Morar, Adriana ^[2]; Herman, Viorel ^[2]; ^[3]; Mukhtar, Hamid ^[4]; Arslan-Acaroz, Damla ^[3]; ^[3]; ^[5]

Afyon Kocatepe University, Afyonkarahisar (Turkey); Montana State Univ., Bozeman, MT (United States)
King Michael I University of Life Sciences, Timișoara (Romania)
Afyon Kocatepe University, Afyonkarahisar (Turkey)
Government College University, Lahore (Pakistan)
Montana State Univ., Bozeman, MT (United States)

Biofilm formation on surfaces via microbial colonization causes infections and has become a major health issue globally. The biofilm lifestyle provides resistance to environmental stresses and antimicrobial therapies. Biofilms can cause several chronic conditions, and effective treatment has become a challenge due to increased antimicrobial resistance. Antibiotics available for treating biofilm-associated infections are generally not very effective and require high doses that may cause toxicity in the host. Therefore, it is essential to study and develop efficient anti-biofilm strategies that can significantly reduce the rate of biofilm-associated healthcare problems. In this context, some effective combating strategies with potential anti-biofilm agents, including plant extracts, peptides, enzymes, lantibiotics, chelating agents, biosurfactants, polysaccharides, organic, inorganic, and metal nanoparticles, etc., have been reviewed to overcome biofilm-associated healthcare problems. From their extensive literature survey, it can be concluded that these molecules with considerable structural alterations might be applied to the treatment of biofilm-associated infections, by evaluating their significant delivery to the target site of the host. To design effective anti-biofilm molecules, it must be assured that the minimum inhibitory concentrations of these anti-biofilm compounds can eradicate biofilm-associated infections without causing toxic effects at a significant rate.

View Accepted Manuscript (DOE)

Research Organization:: Montana State Univ., Bozeman, MT (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Office of Sustainable Transportation. Bioenergy Technologies Office (BETO); National Science Foundation (NSF)

Grant/Contract Number:: EE0009273

OSTI ID:: 1904777

Journal Information:: Life, Journal Name: Life Journal Issue: 8 Vol. 12; ISSN 2075-1729

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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