Comparison of Intact Arabidopsis thaliana Leaf Transcript Profiles during Treatment with Inhibitors of Mitochondrial Electron Transport and TCA Cycle

Umbach, Ann L.; Zarkovic, Jelena; Yu, Jianping; Ruckle, Michael E.; McIntosh, Lee; Hock, Jeffery J.; Bingham, Scott; White, Samuel J.; George, Rajani M.; Subbaiah, Chalivendra C.; Rhoads, David M.

doi:10.1371/journal.pone.0044339

Comparison of Intact Arabidopsis thaliana Leaf Transcript Profiles during Treatment with Inhibitors of Mitochondrial Electron Transport and TCA Cycle

Journal Article · Tue Sep 18 00:00:00 UTC 2012 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0044339· OSTI ID:1904596

Umbach, Ann L. ^[1]; Zarkovic, Jelena ^[2]; Yu, Jianping ^[3]; Ruckle, Michael E. ^[3]; McIntosh, Lee ^[3]; Hock, Jeffery J. ^[2]; Bingham, Scott ^[2]; White, Samuel J. ^[2]; George, Rajani M. ^[2]; Subbaiah, Chalivendra C. ^[2]; Rhoads, David M. ^[4]

Duke University, Durham, NC (United States); Univ. of Arizona, Tucson, AZ (United States)
Arizona State University, Tempe, AZ (United States)
Michigan State University, East Lansing, MI (United States)
University of Arizona, Tucson, AZ (United States)

Plant mitochondria signal to the nucleus leading to altered transcription of nuclear genes by a process called mitochondrial retrograde regulation (MRR). MRR is implicated in metabolic homeostasis and responses to stress conditions. Mitochondrial reactive oxygen species (mtROS) are a MRR signaling component, but whether all MRR requires ROS is not established. Inhibition of the cytochrome respiratory pathway by antimycin A (AA) or the TCA cycle by monofluoroacetate (MFA), each of which initiates MRR, can increase ROS production in some plant cells. We found that for AA and MFA applied to leaves of soil-grown Arabidopsis thaliana plants, ROS production increased with AA, but not with MFA, allowing comparison of transcript profiles under different ROS conditions during MRR. Variation in transcript accumulation over time for eight nuclear encoded mitochondrial protein genes suggested operation of both common and distinct signaling pathways between the two treatments. Consequences of mitochondrial perturbations for the whole transcriptome were examined by microarray analyses. Expression of 1316 and 606 genes was altered by AA and MFA, respectively. A subset of genes was similarly affected by both treatments, including genes encoding photosynthesis-related proteins. MFA treatment resulted in more down-regulation. Functional gene category (MapMan) and cluster analyses showed that genes with expression levels affected by perturbation from AA or MFA inhibition were most similarly affected by biotic stresses such as pathogens. Overall, the data provide further evidence for the presence of mtROS-independent MRR signaling, and support the proposed involvement of MRR and mitochondrial function in plant responses to biotic stress.

View Accepted Manuscript (DOE)

Research Organization:: Michigan State University, East Lansing, MI (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC)

Grant/Contract Number:: FG02-91ER20021

OSTI ID:: 1904596

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 9 Vol. 7; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
Arabidopsis thaliana
citric acid cycle
clustering algorithms
gene expression
leaves
microarrays
mitochondria
transcriptome analysis

Comparison of Intact Arabidopsis thaliana Leaf Transcript Profiles during Treatment with Inhibitors of Mitochondrial Electron Transport and TCA Cycle

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References (75)

Cited By (4)

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