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Title: Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G

Journal Article · · Nat. Commun.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NCI; National Institutes of Health (NIH)
OSTI ID:
1902366
Journal Information:
Nat. Commun., Vol. 13
Country of Publication:
United States
Language:
ENGLISH

References (64)

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Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction and Other Cellular Functions journal March 2021
APOBEC3G Restricts HIV-1 to a Greater Extent than APOBEC3F and APOBEC3DE in Human Primary CD4 + T Cells and Macrophages journal January 2013
Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1 journal August 2011
Retroviruses drive the rapid evolution of mammalian APOBEC3 genes journal December 2019
High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition journal October 2006
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The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA journal May 2003
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome journal April 2004
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts journal May 2003
APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase journal April 2004
Extremely High Mutation Rate of HIV-1 In Vivo journal September 2015
APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure journal April 2013
The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme journal December 2016
Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G journal December 2017
Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells journal February 2019
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein journal July 2002
APOBEC3G restricts early HIV-1 replication in the cytoplasm of target cells journal May 2008
Retroviral restriction by APOBEC proteins journal November 2004
APOBEC3 proteins can copackage and comutate HIV-1 genomes journal July 2016
Antiviral Function of APOBEC3G Can Be Dissociated from Cytidine Deaminase Activity journal January 2005
Inhibition of \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{tRNA}_{3}^{\mathrm{Lys}}\) \end{document}-Primed Reverse Transcription by Human APOBEC3G during Human Immunodeficiency Virus Type 1 Replication journal December 2006
Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G journal October 2007
APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts journal December 2008
The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral Replication journal April 2012
Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4 + T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine Deamination journal November 2012
Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein journal November 2013
Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G journal November 2017
The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid journal August 2016
Characterization of APOBEC3G binding to 7SL RNA journal July 2008
Functional Analysis and Structural Modeling of Human APOBEC3G Reveal the Role of Evolutionarily Conserved Elements in the Inhibition of Human Immunodeficiency Virus Type 1 Infection and Alu Transposition journal September 2009
RNA-Dependent Oligomerization of APOBEC3G Is Required for Restriction of HIV-1 journal March 2009
Association of Potent Human Antiviral Cytidine Deaminases with 7SL RNA and Viral RNP in HIV-1 Virions journal October 2010
Binding of RNA by APOBEC3G controls deamination-independent restriction of retroviruses journal June 2013
RNA-binding residues in the N-terminus of APOBEC3G influence its DNA sequence specificity and retrovirus restriction efficiency journal September 2015
Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G journal May 2015
Crystal structures of APOBEC3G N-domain alone and its complex with DNA journal August 2016
Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association journal May 2019
Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G journal January 2020
Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains journal November 2020
Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 -RNA Recognition Element journal January 1998
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Potential Intra- and Intermolecular Interactions Involving the Unique-5′ Region of the HIV-1 5′-UTR journal November 2008
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Unpaired Guanosines in the 5′ Untranslated Region of HIV-1 RNA Act Synergistically To Mediate Genome Packaging journal October 2020
Multiple, Switchable Protein:RNA Interactions Regulate Human Immunodeficiency Virus Type 1 Assembly journal September 2018
NMR Studies of Retroviral Genome Packaging journal September 2020
APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA journal October 2017
Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA journal July 2018
The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism journal January 2018
HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA journal December 2019
Architecture and secondary structure of an entire HIV-1 RNA genome journal August 2009
Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1 journal January 2015
The biased nucleotide composition of the HIV genome: a constant factor in a highly variable virus journal November 2012
The A-nucleotide preference of HIV-1 in the context of its structured RNA genome journal February 2013
A Guanosine-Centric Mechanism for RNA Chaperone Function journal March 2013
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Correcting pervasive errors in RNA crystallography through enumerative structure prediction journal December 2012
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Macromolecular complexes in crystals and solutions journal March 2011
Inference of Macromolecular Assemblies from Crystalline State journal September 2007

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