Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton?s Tyrosine Kinase

Tichenor, Mark S.; Wiener, John J.M.; Rao, Navin L.; Bacani, Genesis M.; Wei, Jianmei; Deckhut, Charlotte Pooley; Barbay, J. Kent; Kreutter, Kevin D.; Chang, Leon; Clancy, Kathleen W.; Murrey, Heather E.; Wang, Weixue; Ahn, Kay; Huber, Michael; Rex, Elizabeth; Coe, Kevin J.; Wu, Jiejun; Rui, Haopeng; Sepassi, Kia; Gaudiano, Marcello; Bekkers, Mariette; Cornelissen, Ivo; Packman, Kathryn; Seierstad, Mark; Xiouras, Christos; Bembenek, Scott D.; Alexander, Richard; Milligan, Cynthia; Balasubramanian, Sriram; Lebsack, Alec D.; Venable, Jennifer D.; Philippar, Ulrike; Edwards, James P.; Hirst, Gavin

doi:10.1021/acs.jmedchem.2c01026

Title: Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton?s Tyrosine Kinase

Journal Article · Sat Oct 01 00:00:00 EDT 2022 · J. Med. Chem.

DOI:https://doi.org/10.1021/acs.jmedchem.2c01026· OSTI ID:1902355

Tichenor, Mark S.; Wiener, John J.M.; Rao, Navin L.; Bacani, Genesis M.; Wei, Jianmei; Deckhut, Charlotte Pooley; Barbay, J. Kent; Kreutter, Kevin D.; Chang, Leon; Clancy, Kathleen W.; Murrey, Heather E.; Wang, Weixue; Ahn, Kay; Huber, Michael; Rex, Elizabeth; Coe, Kevin J.; Wu, Jiejun; Rui, Haopeng; Sepassi, Kia; Gaudiano, Marcello more »

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1902355

Journal Information:: J. Med. Chem., Vol. 65, Issue (21)

Country of Publication:: United States

Language:: ENGLISH

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