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Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA

Journal Article · · ACS Infect. Dis.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; FOREIGN
OSTI ID:
1901315
Journal Information:
ACS Infect. Dis., Journal Name: ACS Infect. Dis. Journal Issue: (10) Vol. 8
Country of Publication:
United States
Language:
ENGLISH

References (65)

The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis journal August 1992
Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline journal July 2020
An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases journal February 2007
Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA journal December 2017
Mycobacterium enoyl acyl carrier protein reductase (InhA): A key target for antitubercular drug discovery journal October 2021
Mycobacterium abscessus: Environmental Bacterium Turned Clinical Nightmare journal March 2019
A new piperidinol derivative targeting mycolic acid transport inMycobacterium abscessus journal June 2016
New use of BCG for recombinant vaccines journal June 1991
Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent journal July 2016
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease journal August 2011
Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria journal June 2012
Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384 journal April 2017
Molecular Epidemiology of Mycobacterium abscessus , with Focus on Cystic Fibrosis journal May 2007
Glycopeptidolipids, a Double-Edged Sword of the Mycobacterium abscessus Complex journal June 2018
In vitro evaluation of a new drug combination against clinical isolates belonging to the Mycobacterium abscessus complex journal December 2014
KatG as Counterselection Marker for Nontuberculous Mycobacteria journal April 2020
The distinct fate of smooth and roughMycobacterium abscessusvariants inside macrophages journal November 2016
Demonstration of Cord Formation by Rough Mycobacterium abscessus Variants: Implications for the Clinical Microbiology Laboratory journal June 2011
Bactericidal and intracellular activity of β-lactams againstMycobacterium abscessus journal February 2016
TheMycobacterium tuberculosisFAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development journal June 2007
Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients journal January 2015
Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response journal April 2011
Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone journal December 2014
Acute Respiratory Failure Involving an R Variant of Mycobacterium abscessus journal January 2009
The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance journal September 2018
Reinstating Mycobacterium massiliense and Mycobacterium bolletii as species of the Mycobacterium abscessus complex journal August 2017
Mycobacterium abscessus: a new antibiotic nightmare journal January 2012
Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium smegmatis journal July 2000
NTM drug discovery: status, gaps and the way forward journal August 2018
Cyclipostins and Cyclophostin Analogues as Multitarget Inhibitors That Impair Growth of Mycobacterium abscessus journal July 2019
Heterologous Expression of ethA and katG in Mycobacterium marinum Enables the Rapid Identification of New Prodrugs Active against Mycobacterium tuberculosis journal March 2021
Rifabutin Is Bactericidal against Intracellular and Extracellular Forms of Mycobacterium abscessus journal October 2020
Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase journal June 2003
Crystal Structure of the Mycobacterium tuberculosis Enoyl-ACP Reductase, InhA, in Complex with NAD + and a C16 Fatty Acyl Substrate journal May 1999
Mycobacteria–host interactions in human bronchiolar airway organoids journal November 2021
Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation journal February 2014
Coot model-building tools for molecular graphics journal November 2004
Clinical experience in 52 patients with tigecycline-containing regimens for salvage treatment of Mycobacterium abscessus and Mycobacterium chelonae infections journal March 2014
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid journal August 2006
Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung journal June 2012
Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members: MmpL activity is dependent on a crucial tyrosine journal December 2015
Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus journal February 2020
In vitro activity of cefoxitin and imipenem against Mycobacterium abscessus complex journal May 2014
Active Benzimidazole Derivatives Targeting the MmpL3 Transporter in Mycobacterium abscessus journal December 2019
Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid journal September 1999
Non-tuberculous mycobacterial pulmonary disease journal June 2019
Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success journal August 2011
The Integrated Resource for Reproducibility in Macromolecular Crystallography: Experiences of the first four years journal November 2019
Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections journal June 2017
Rifabutin: A Repurposing Candidate for Mycobacterium abscessus Lung Disease journal February 2020
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary journal December 2015
EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets journal March 2007
Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria journal June 2003
Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis journal January 1998
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis journal January 1994
Mn(III) Pyrophosphate as an Efficient Tool for Studying the Mode of Action of Isoniazid on the InhA Protein of Mycobacterium tuberculosis journal July 2002
Clinical Significance of Differentiation of Mycobacterium massiliense from Mycobacterium abscessus journal February 2011
Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis journal March 2010
Direct inhibitors of InhA are active against Mycobacterium tuberculosis journal January 2015
Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria journal July 2012
Spontaneous reversion of Mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype journal June 2006
Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo journal January 2018
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance journal November 2003
Overexpression, Purification, and Characterization of the Catalase-peroxidase KatG from Mycobacterium tuberculosis journal January 1997

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