Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran sa

Chen, Zhou; Zakrzewska, Sandra; Hajare, Holly S.; Alvarez-Buylla, Aurora; Abderemane-Ali, Fayal; Bogan, Maximiliana; Ramirez, Dave; O?Connell, Lauren A.; Du Bois, J.; Minor Jr., Daniel L.

doi:10.1073/pnas.2210114119

Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran sa

Journal Article · 01 October 2022 · Proc. Natl. Acad. Sci. USA

DOI:https://doi.org/10.1073/pnas.2210114119· OSTI ID:1901195

Chen, Zhou; Zakrzewska, Sandra; Hajare, Holly S.; Alvarez-Buylla, Aurora; Abderemane-Ali, Fayal; Bogan, Maximiliana; Ramirez, Dave; O?Connell, Lauren A.; Du Bois, J.; Minor Jr., Daniel L.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; DOD; OTHER U.S. STATES

OSTI ID:: 1901195

Journal Information:: Proc. Natl. Acad. Sci. USA, Journal Name: Proc. Natl. Acad. Sci. USA Journal Issue: (44) Vol. 119

Country of Publication:: United States

Language:: ENGLISH

References (45)

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability Niesen, Frank H.; Berglund, Helena; Vedadi, Masoud Nature Protocols, Vol. 2, Issue 9 https://doi.org/10.1038/nprot.2007.321	journal	September 2007
Global versus local mechanisms of temperature sensing in ion channels Arrigoni, Cristina; Minor, Daniel L. Pflügers Archiv - European Journal of Physiology, Vol. 470, Issue 5 https://doi.org/10.1007/s00424-017-2102-z	journal	January 2018
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins Abderemane-Ali, Fayal; Rossen, Nathan D.; Kobiela, Megan E. Journal of General Physiology, Vol. 153, Issue 9 https://doi.org/10.1085/jgp.202112872	journal	August 2021
Application of Fluorescence Polarization in HTS Assays Huang, Xinyi; Aulabaugh, Ann Methods in Molecular Biology https://doi.org/10.1007/978-1-4939-3673-1_7	book	January 2016
Saxiphilin, a Saxitoxin-binding Protein with Two Thyroglobulin Type 1 Domains, Is an Inhibitor of Papain-like Cysteine Proteinases Lenarčič, Brigita; Krishnan, Gomathi; Borukhovich, Renata Journal of Biological Chemistry, Vol. 275, Issue 20 https://doi.org/10.1074/jbc.M001406200	journal	March 2000
Saxitoxin Is a Gating Modifier of hERG K+ Channels Wang, Jixin; Salata, Joseph J.; Bennett, Paul B. The Journal of General Physiology, Vol. 121, Issue 6 https://doi.org/10.1085/jgp.200308812	journal	May 2003
Protein stability curves Becktel, Wayne J.; Schellman, John A. Biopolymers, Vol. 26, Issue 11 https://doi.org/10.1002/bip.360261104	journal	November 1987
Saxitoxin Thottumkara, Arun P.; Parsons, William H.; Du Bois, J. Angewandte Chemie International Edition, Vol. 53, Issue 23 https://doi.org/10.1002/anie.201308235	journal	April 2014
Molecular physiology of chemical defenses in a poison frog Caty, Stephanie N.; Alvarez-Buylla, Aurora; Byrd, Gary D. Journal of Experimental Biology https://doi.org/10.1242/jeb.204149	journal	January 2019
Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNa _V 1.7 Thomas-Tran, Rhiannon; Du Bois, J. Proceedings of the National Academy of Sciences, Vol. 113, Issue 21 https://doi.org/10.1073/pnas.1603486113	journal	May 2016
Purification and partial characterization of paralytic shellfish poison-binding protein from Acanthocardia tuberculatum Takati, Nadia; Mountassif, Driss; Taleb, Hamid Toxicon, Vol. 50, Issue 3 https://doi.org/10.1016/j.toxicon.2007.04.016	journal	September 2007
Purification, characterization, and cDNA cloning of a novel soluble saxitoxin and tetrodotoxin binding protein from plasma of the puffer fish, Fugu pardalis: A novel saxitoxin and tetrodotoxin binding protein Yotsu-Yamashita, Mari; Sugimoto, Atsuko; Terakawa, Takahiro European Journal of Biochemistry, Vol. 268, Issue 22 https://doi.org/10.1046/j.0014-2956.2001.02547.x	journal	November 2001
Neutralizing effect of hemolymph from the shore crab, Thalamita crenata, on paralytic shellfish toxins Lin, Huajuan; Zhang, Chaohua; Liao, Jianmeng Toxicon, Vol. 99 https://doi.org/10.1016/j.toxicon.2015.03.010	journal	June 2015
De Novo Synthesis of Modified Saxitoxins for Sodium Ion Channel Study Andresen, Brian M.; Du Bois, J. Journal of the American Chemical Society, Vol. 131, Issue 35 https://doi.org/10.1021/ja904179f	journal	August 2009
A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS Sivilotti, L.; Okuse, K.; Akopian, A. N. FEBS Letters, Vol. 409, Issue 1 https://doi.org/10.1016/S0014-5793(97)00479-1	journal	June 1997
Neurotoxic Alkaloids: Saxitoxin and Its Analogs Wiese, Maria; D’Agostino, Paul M.; Mihali, Troco K. Marine Drugs, Vol. 8, Issue 7 https://doi.org/10.3390/md8072185	journal	July 2010
Biocatalytic Detoxification of Paralytic Shellfish Toxins Lukowski, April L.; Denomme, Nicholas; Hinze, Meagan E. ACS Chemical Biology, Vol. 14, Issue 5 https://doi.org/10.1021/acschembio.9b00123	journal	April 2019
Phylogenomics reveals rapid, simultaneous diversification of three major clades of Gondwanan frogs at the Cretaceous–Paleogene boundary Feng, Yan-Jie; Blackburn, David C.; Liang, Dan Proceedings of the National Academy of Sciences, Vol. 114, Issue 29 https://doi.org/10.1073/pnas.1704632114	journal	July 2017
Molecular cloning of bullfrog saxiphilin: a unique relative of the transferrin family that binds saxitoxin. Morabito, M. A.; Moczydlowski, E. Proceedings of the National Academy of Sciences, Vol. 91, Issue 7 https://doi.org/10.1073/pnas.91.7.2478	journal	March 1994
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins Yen, Tien-Jui; Lolicato, Marco; Thomas-Tran, Rhiannon Science Advances, Vol. 5, Issue 6 https://doi.org/10.1126/sciadv.aax2650	journal	June 2019
Saxitoxin binding sites in frog-myocardial cytosol Doyle, D.; Wong, M.; Tanaka, J. Science, Vol. 215, Issue 4536 https://doi.org/10.1126/science.6278588	journal	February 1982
Analysis of Protein Stability and Ligand Interactions by Thermal Shift Assay Huynh, Kathy; Partch, Carrie L. Current Protocols in Protein Science, Vol. 79, Issue 1 https://doi.org/10.1002/0471140864.ps2809s79	journal	February 2015
Phylogenetic survey of soluble saxitoxin-binding activity in pursuit of the function and molecular evolution of saxiphilin, a relative of transferrin Llewellyn, Lyndon E.; Bell, Peter M.; Moczydlowski, Edward G. Proceedings of the Royal Society of London. Series B: Biological Sciences, Vol. 264, Issue 1383 https://doi.org/10.1098/rspb.1997.0124	journal	June 1997
Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels Durán-Riveroll, Lorena; Cembella, Allan Marine Drugs, Vol. 15, Issue 10 https://doi.org/10.3390/md15100303	journal	October 2017
A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties Satin, J.; Kyle, J. W.; Chen, M. Science, Vol. 256, Issue 5060 https://doi.org/10.1126/science.256.5060.1202	journal	May 1992
Pharmacological and biochemical properties of saxiphilin, a soluble saxitoxin-binding protein from the bullfrog (Rana catesbeiana) Mahar, Janice; Lukács, Gergely L.; Li, Li Toxicon, Vol. 29, Issue 1 https://doi.org/10.1016/0041-0101(91)90039-T	journal	January 1991
Additivity of mutational effects in proteins Wells, James A. Biochemistry, Vol. 29, Issue 37, p. 8509-8517 https://doi.org/10.1021/bi00489a001	journal	September 1990
Structural basis for divergent C–H hydroxylation selectivity in two Rieske oxygenases Lukowski, April L.; Liu, Jianxin; Bridwell-Rabb, Jennifer Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-16729-0	journal	June 2020
Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue Leffler, Andreas; Herzog, Raimund I.; Dib-Hajj, Sulayman D. Pflügers Archiv - European Journal of Physiology, Vol. 451, Issue 3 https://doi.org/10.1007/s00424-005-1463-x	journal	June 2005
Sodium channels in vertebrate hearts. Three types of saxitoxin binding sites in heart Tanaka, Jacqueline C.; Doyle, Donald D.; Barr, Lloyd Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 775, Issue 2 https://doi.org/10.1016/0005-2736(84)90172-X	journal	August 1984
Analysis of protein-ligand interactions by fluorescence polarization Rossi, Ana M.; Taylor, Colin W. Nature Protocols, Vol. 6, Issue 3 https://doi.org/10.1038/nprot.2011.305	journal	March 2011
A hot spot of binding energy in a hormone-receptor interface Clackson, T.; Wells, J. Science, Vol. 267, Issue 5196 https://doi.org/10.1126/science.7529940	journal	January 1995
Evidence for massive and recurrent toxic blooms of Alexandrium catenella in the Alaskan Arctic Anderson, Donald M.; Fachon, Evangeline; Pickart, Robert S. Proceedings of the National Academy of Sciences, Vol. 118, Issue 41 https://doi.org/10.1073/pnas.2107387118	journal	October 2021
Structures of human Na _v 1.7 channel in complex with auxiliary subunits and animal toxins Shen, Huaizong; Liu, Dongliang; Wu, Kun Science, Vol. 363, Issue 6433 https://doi.org/10.1126/science.aaw2493	journal	February 2019
Saxitoxin Blocks L-Type I _Ca Su, Zhi; Sheets, Michael; Ishida, Hideyuki Journal of Pharmacology and Experimental Therapeutics, Vol. 308, Issue 1 https://doi.org/10.1124/jpet.103.056564	journal	October 2003
Saxitoxin, a toxic marine natural product that targets a multitude of receptors Llewellyn, Lyndon E. Natural Product Reports, Vol. 23, Issue 2 https://doi.org/10.1039/b501296c	journal	January 2006
Differentiation of the actions of tetrodotoxin and saxitoxin Kao, C. Y.; Fuhrman, Frederick A. Toxicon, Vol. 5, Issue 1 https://doi.org/10.1016/0041-0101(67)90114-6	journal	July 1967
Fluorescence anisotropy (polarization): from drug screening to precision medicine Zhang, Hairong; Wu, Qian; Berezin, Mikhail Y. Expert Opinion on Drug Discovery, Vol. 10, Issue 11 https://doi.org/10.1517/17460441.2015.1075001	journal	August 2015
Structural basis for the modulation of voltage-gated sodium channels by animal toxins Shen, Huaizong; Li, Zhangqiang; Jiang, Yan Science, Vol. 362, Issue 6412 https://doi.org/10.1126/science.aau2596	journal	July 2018
Fluorescent Saxitoxins for Live Cell Imaging of Single Voltage-Gated Sodium Ion Channels beyond the Optical Diffraction Limit Ondrus, Alison E.; Lee, Hsiao-lu D.; Iwanaga, Shigeki Chemistry & Biology, Vol. 19, Issue 7 https://doi.org/10.1016/j.chembiol.2012.05.021	journal	July 2012
Characterization of Saxitoxin Binding to Saxiphilin, a Relative of the Transferrin Family That Displays pH-Dependent Ligand Binding Llewellyn, Lyndon E.; Moczydlowski, Edward G. Biochemistry, Vol. 33, Issue 40 https://doi.org/10.1021/bi00206a039	journal	October 1994
Distribution of homologous proteins to puffer fish saxitoxin and tetrodotoxin binding protein in the plasma of puffer fish and among the tissues of Fugu pardalis examined by Western blot analysis Yotsu-Yamashita, Mari; Yamaki, Hiroe; Okoshi, Natsumi Toxicon, Vol. 55, Issue 6 https://doi.org/10.1016/j.toxicon.2009.12.021	journal	June 2010
Cation-π Interactions and their Functional Roles in Membrane Proteins Infield, Daniel T.; Rasouli, Ali; Galles, Grace D. Journal of Molecular Biology, Vol. 433, Issue 17 https://doi.org/10.1016/j.jmb.2021.167035	journal	August 2021
Rapid toxin sequestration modifies poison frog physiology O'Connell, Lauren A.; O'Connell, Jeremy D.; Paulo, Joao A. Journal of Experimental Biology, Vol. 224, Issue 3 https://doi.org/10.1242/jeb.230342	journal	February 2021
Molecular basis for pharmacological differences between brain and cardiac sodium channels Heinemann, Stefan H.; Terlau, Heinrich; Imoto, Keiji Pfl�gers Archiv European Journal of Physiology, Vol. 422, Issue 1 https://doi.org/10.1007/BF00381519	journal	October 1992

Similar Records

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins

Journal Article · 2024 · Nature Communications · OSTI ID:2570836

Verification of dosimetric accuracy on the TrueBeam STx: Rounded leaf effect of the high definition MLC

Journal Article · 2012 · Medical Physics · OSTI ID:22099052

Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1

Journal Article · 2020 · ACS Chemical Biology · OSTI ID:1635027

Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran sa

Citation Formats

References (45)

Similar Records

Related Subjects