skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Conformation and Pairing Properties of an O[superscript 6]-Methyl-2;#8242;-deoxyguanosine-Directed B

Journal Article · · Chem. Res. Toxicol.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
Journal Information:
Chem. Res. Toxicol., Vol. 35, Issue (10)
Country of Publication:
United States

References (47)

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides journal July 1969
DNA Methylation Damage: Formation, Repair and Biological Consequences book January 2007
Alkylation damage in DNA and RNA—repair mechanisms and medical significance journal November 2004
Aberrant methylation of liver DNA in rats during hepatotoxicity journal September 1981
MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents journal August 2007
O6-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke journal August 2012
O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer journal August 2013
Balancing repair and tolerance of DNA damage caused by alkylating agents journal January 2012
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome. journal October 1984
Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases journal November 1990
Synthesis and characterization of a set of four dodecadeoxyribonucleoside undecaphosphates containing O6-methylguanine opposite adenine, cytosine, guanine, and thymine journal November 1984
Thermodynamic comparison of the base pairs formed by the carcinogenic lesion O6-methylguanine with reference both to Watson-Crick pairs and to mismatched pairs journal July 1989
Structural studies of the O6meG.cntdot.T interaction in the d(C-G-T-G-A-A-T-T-C-O6meG-C-G) duplex journal March 1986
The structural basis for the mutagenicity of O6-methyl-guanine lesions journal December 2006
Sulfolobus solfataricus DNA Polymerase Dpo4 Is Partially Inhibited by “Wobble” Pairing between O 6 -Methylguanine and Cytosine, but Accurate Bypass Is Preferred journal November 2006
Structural Basis for Proficient Incorporation of dTTP Opposite O 6 -Methylguanine by Human DNA Polymerase ι journal October 2010
Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2′-deoxyguanosine by Human DNA Polymerase η journal November 2016
Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase journal January 2017
A Synthetic Nucleoside Probe that Discerns a DNA Adduct from Unmodified DNA journal April 2007
Specific Incorporation of an Artificial Nucleotide Opposite a Mutagenic DNA Adduct by a DNA Polymerase journal December 2014
DNA Adduct-Directed Synthetic Nucleosides journal April 2019
Tolerance of Base Pair Size and Shape in Postlesion DNA Synthesis journal April 2013
O6-Alkylguanine Postlesion DNA Synthesis Is Correct with the Right Complement of Hydrogen Bonding journal October 2014
Hydrogen-Bonding Interactions at the DNA Terminus Promote Extension from Methylguanine Lesions by Human Extender DNA Polymerase ζ journal September 2018
High-resolution structure of a mutagenic lesion in DNA. journal December 1990
Recognition of O6 -benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction journal July 2013
Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342. journal January 1992
Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine journal November 1990
Hydrogen Bonding or Stacking Interactions in Differentiating Duplex Stability in Oligonucleotides Containing Synthetic Nucleoside Probes for Alkylated DNA journal June 2013
Fluorescent Nucleobase Analogues with Extended Pi Surfaces Stabilize DNA Duplexes Containing O 6 -Alkylguanine Adducts journal June 2018
In-Gene Quantification of O6-Methylguanine with Elongated Nucleoside Analogues on Gold Nanoprobes journal July 2016
Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis journal July 2005
Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex journal August 2008
Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes book January 2016
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
The CCP4 suite programs for protein crystallography journal September 1994
MOLREP an Automated Program for Molecular Replacement journal December 1997
REFMAC 5 for the refinement of macromolecular crystal structures journal March 2011
Coot model-building tools for molecular graphics journal November 2004
PRODRG : a tool for high-throughput crystallography of protein–ligand complexes journal July 2004
Towards automated crystallographic structure refinement with phenix.refine journal March 2012
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Conformational transitions in cytidine bulge-containing deoxytridecanucleotide duplexes: extra cytidine equilibrates between looped out (low temperature) and stacked (elevated temperature) conformations in solution journal January 1989
Web 3DNA--a web server for the analysis, reconstruction, and visualization of three-dimensional nucleic-acid structures journal May 2009
The Dickerson-Drew B-DNA Dodecamer Revisited at Atomic Resolution journal January 1999
A “Hydrat-Ion” Spine in a B-DNA Minor Groove journal March 1999
Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing journal September 1999