Structural basis of human TREX1 DNA degradation and autoimmune disease

Zhou, Wen; Richmond-Buccola, Desmond; Wang, Qiannan; Kranzusch, Philip J.

doi:10.1038/s41467-022-32055-z

Structural basis of human TREX1 DNA degradation and autoimmune disease

Journal Article · 01 July 2022 · Nat. Commun.

DOI:https://doi.org/10.1038/s41467-022-32055-z· OSTI ID:1900952

Zhou, Wen; Richmond-Buccola, Desmond; Wang, Qiannan; Kranzusch, Philip J.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; FOREIGN

OSTI ID:: 1900952

Journal Information:: Nat. Commun., Journal Name: Nat. Commun. Vol. 13

Country of Publication:: United States

Language:: ENGLISH

References (47)

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion Nader, Guilherme Pedreira de Freitas; Agüera-Gonzalez, Sonia; Routet, Fiona Cell, Vol. 184, Issue 20 https://doi.org/10.1016/j.cell.2021.08.035	journal	September 2021
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus Crow, Yanick J.; Hayward, Bruce E.; Parmar, Rekha Nature Genetics, Vol. 38, Issue 8 https://doi.org/10.1038/ng1845	journal	July 2006
A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome Haaxma, Charlotte A.; Crow, Yanick J.; van Steensel, Maurice A. M. American Journal of Medical Genetics Part A, Vol. 152A, Issue 10 https://doi.org/10.1002/ajmg.a.33620	journal	August 2010
TREX1 Cuts Down on Cancer Immunogenicity Yamazaki, Takahiro; Galluzzi, Lorenzo Trends in Cell Biology, Vol. 27, Issue 8 https://doi.org/10.1016/j.tcb.2017.06.001	journal	August 2017
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape Hancks, Dustin C.; Hartley, Melissa K.; Hagan, Celia PLOS Genetics, Vol. 11, Issue 5 https://doi.org/10.1371/journal.pgen.1005203	journal	May 2015
Identification and Expression of the TREX1 and TREX2 cDNA Sequences Encoding Mammalian 3′→5′ Exonucleases Mazur, Dan J.; Perrino, Fred W. Journal of Biological Chemistry, Vol. 274, Issue 28 https://doi.org/10.1074/jbc.274.28.19655	journal	July 1999
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing Zhou, Wen; Mohr, Lisa; Maciejowski, John Molecular Cell, Vol. 81, Issue 4 https://doi.org/10.1016/j.molcel.2021.01.024	journal	February 2021
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome Gray, Elizabeth E.; Treuting, Piper M.; Woodward, Joshua J. The Journal of Immunology, Vol. 195, Issue 5 https://doi.org/10.4049/jimmunol.1500969	journal	July 2015
TREX1 is a checkpoint for innate immune sensing of DNA damage that fosters cancer immune resistance Demaria, Sandra; Vanpouille-Box, Claire Emerging Topics in Life Sciences, Vol. 1, Issue 5 https://doi.org/10.1042/ETLS20170063	journal	December 2017
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi‐Goutières syndrome Ramantani, Georgia; Kohlhase, Jürgen; Hertzberg, Christoph Arthritis & Rheumatism, Vol. 62, Issue 5 https://doi.org/10.1002/art.27367	journal	April 2010
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Human Disease Phenotypes Associated With Mutations in TREX1 Rice, Gillian I.; Rodero, Mathieu P.; Crow, Yanick J. Journal of Clinical Immunology, Vol. 35, Issue 3 https://doi.org/10.1007/s10875-015-0147-3	journal	March 2015
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment Quevedo, Camilo E.; Cruz-Migoni, Abimael; Bery, Nicolas Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-05707-2	journal	August 2018
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity Vanpouille-Box, Claire; Alard, Amandine; Aryankalayil, Molykutty J. Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms15618	journal	June 2017
Global indicators of X-ray data quality Weiss, Manfred S. Journal of Applied Crystallography, Vol. 34, Issue 2 https://doi.org/10.1107/S0021889800018227	journal	April 2001
Clinical and Molecular Phenotype of Aicardi-Goutières Syndrome Rice, Gillian; Patrick, Teresa; Parmar, Rekha The American Journal of Human Genetics, Vol. 81, Issue 4 https://doi.org/10.1086/521373	journal	October 2007
Linking Crystallographic Model and Data Quality Karplus, P. A.; Diederichs, K. Science, Vol. 336, Issue 6084 https://doi.org/10.1126/science.1218231	journal	May 2012
Structure of the Dimeric Exonuclease TREX1 in Complex with DNA Displays a Proline-rich Binding Site for WW Domains Brucet, Marina; Querol-Audí, Jordi; Serra, Maria Journal of Biological Chemistry, Vol. 282, Issue 19 https://doi.org/10.1074/jbc.M700236200	journal	May 2007
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway Sun, L.; Wu, J.; Du, F. Science, Vol. 339, Issue 6121 https://doi.org/10.1126/science.1232458	journal	December 2012
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease Grieves, Jessica L.; Fye, Jason M.; Harvey, Scott Proceedings of the National Academy of Sciences, Vol. 112, Issue 16 https://doi.org/10.1073/pnas.1423804112	journal	April 2015
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus Lee-Kirsch, Min Ae; Gong, Maolian; Chowdhury, Dipanjan Nature Genetics, Vol. 39, Issue 9 https://doi.org/10.1038/ng2091	journal	July 2007
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING Ablasser, Andrea; Goldeck, Marion; Cavlar, Taner Nature, Vol. 498, Issue 7454 https://doi.org/10.1038/nature12306	journal	May 2013
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus Lee-Kirsch, Min Ae; Chowdhury, Dipanjan; Harvey, Scott Journal of Molecular Medicine, Vol. 85, Issue 5 https://doi.org/10.1007/s00109-007-0199-9	journal	April 2007
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase Gao, Pu; Ascano, Manuel; Wu, Yang Cell, Vol. 153, Issue 5 https://doi.org/10.1016/j.cell.2013.04.046	journal	May 2013
DNA-induced liquid phase condensation of cGAS activates innate immune signaling Du, Mingjian; Chen, Zhijian J. Science, Vol. 361, Issue 6403 https://doi.org/10.1126/science.aat1022	journal	July 2018
Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome Fye, Jason M.; Orebaugh, Clinton D.; Coffin, Stephanie R. Journal of Biological Chemistry, Vol. 286, Issue 37 https://doi.org/10.1074/jbc.M111.276287	journal	September 2011
TREX1 as a Novel Immunotherapeutic Target Hemphill, Wayne O.; Simpson, Sean R.; Liu, Mingyong Frontiers in Immunology, Vol. 12 https://doi.org/10.3389/fimmu.2021.660184	journal	April 2021
The Crystal Structure of TREX1 Explains the 3′ Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering de Silva, Udesh; Choudhury, Sumana; Bailey, Suzanna L. Journal of Biological Chemistry, Vol. 282, Issue 14 https://doi.org/10.1074/jbc.M700039200	journal	April 2007
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING Diner, Elie J.; Burdette, Dara L.; Wilson, Stephen C. Cell Reports, Vol. 3, Issue 5 https://doi.org/10.1016/j.celrep.2013.05.009	journal	May 2013
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex Kucej, Martin; Fermaintt, Charles S.; Yang, Kun Cell Reports, Vol. 18, Issue 11 https://doi.org/10.1016/j.celrep.2017.02.051	journal	March 2017
Ligand binding at the protein–lipid interface: strategic considerations for drug design Payandeh, Jian; Volgraf, Matthew Nature Reviews Drug Discovery, Vol. 20, Issue 9 https://doi.org/10.1038/s41573-021-00240-2	journal	July 2021
Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases Brucet, Marina; Querol‐Audí, Jordi; Bertlik, Kamila Protein Science, Vol. 17, Issue 12 https://doi.org/10.1110/ps.036426.108	journal	December 2008
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity Orebaugh, Clinton D.; Fye, Jason M.; Harvey, Scott Journal of Biological Chemistry, Vol. 286, Issue 46 https://doi.org/10.1074/jbc.M111.297903	journal	November 2011
cGAS in action: Expanding roles in immunity and inflammation Ablasser, Andrea; Chen, Zhijian J. Science, Vol. 363, Issue 6431 https://doi.org/10.1126/science.aat8657	journal	March 2019
Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease Bailey, Suzanna L.; Harvey, Scott; Perrino, Fred W. DNA Repair, Vol. 11, Issue 1 https://doi.org/10.1016/j.dnarep.2011.10.007	journal	January 2012
Fiji: an open-source platform for biological-image analysis Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Erwin Nature Methods, Vol. 9, Issue 7 https://doi.org/10.1038/nmeth.2019	journal	June 2012
Pervasive Protein Thermal Stability Variation during the Cell Cycle Becher, Isabelle; Andrés-Pons, Amparo; Romanov, Natalie Cell, Vol. 173, Issue 6 https://doi.org/10.1016/j.cell.2018.03.053	journal	May 2018
Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1 Huang, Kuan-Wei; Liu, Tung-Chang; Liang, Ruei-Yue PLOS Biology, Vol. 16, Issue 5 https://doi.org/10.1371/journal.pbio.2005653	journal	May 2018
Immune Diseases Associated with TREX1 and STING Dysfunction Yan, Nan Journal of Interferon & Cytokine Research, Vol. 37, Issue 5 https://doi.org/10.1089/jir.2016.0086	journal	May 2017
Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance Zhou, Wen; Whiteley, Aaron T.; de Oliveira Mann, Carina C. Cell, Vol. 174, Issue 2 https://doi.org/10.1016/j.cell.2018.06.026	journal	July 2018
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING Zhang, Xu; Shi, Heping; Wu, Jiaxi Molecular Cell, Vol. 51, Issue 2 https://doi.org/10.1016/j.molcel.2013.05.022	journal	July 2013
Rules of Engagement: Molecular Insights from Host-Virus Arms Races Daugherty, Matthew D.; Malik, Harmit S. Annual Review of Genetics, Vol. 46, Issue 1 https://doi.org/10.1146/annurev-genet-110711-155522	journal	December 2012
Excision of 3′ Termini by the Trex1 and TREX2 3′→5′ Exonucleases Mazur, Dan J.; Perrino, Fred W. Journal of Biological Chemistry, Vol. 276, Issue 20 https://doi.org/10.1074/jbc.M100623200	journal	May 2001
The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination Orebaugh, Clinton D.; Fye, Jason M.; Harvey, Scott Journal of Biological Chemistry, Vol. 288, Issue 40 https://doi.org/10.1074/jbc.M113.503391	journal	October 2013

Similar Records

Structural Basis of Chronic Beryllium Disease: Linking Allergic Hypersensitivity and Autoimmunity

Journal Article · 2014 · Cell · OSTI ID:1140258

Structural Basis for DNA Recognition by the Human PAX3 Homedomain

Journal Article · 2008 · Biochemistry · OSTI ID:980502

Structural basis for the D-stereoselectivity of human DNA polymerase β

Journal Article · 2017 · Nucleic Acids Research · OSTI ID:1506518

Structural basis of human TREX1 DNA degradation and autoimmune disease

Citation Formats

References (47)

Similar Records

Related Subjects