skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints

Journal Article · · Nat. Commun.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1900624
Journal Information:
Nat. Commun., Vol. 13
Country of Publication:
United States
Language:
ENGLISH

References (57)

Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair journal August 2004
Alternative end-joining pathway(s): Bricolage at DNA breaks journal May 2014
DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae journal November 2015
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? journal November 2015
The Frameshift Infidelity of Human DNA Polymerase λ journal September 2003
Up-regulation of the Fidelity of Human DNA Polymerase λ by Its Non-enzymatic Proline-rich Domain journal July 2006
Template strand scrunching during DNA gap repair synthesis by human polymerase λ journal August 2009
Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age journal July 2014
Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA:  Evidence for an Induced Fit Mechanism , journal September 1997
Structural Comparison of DNA Polymerase Architecture Suggests a Nucleotide Gateway to the Polymerase Active Site journal December 2013
A closed conformation for the Pol λ catalytic cycle journal December 2004
Substrate‐induced DNA strand misalignment during catalytic cycling by DNA polymerase λ journal March 2008
Loop 1 modulates the fidelity of DNA polymerase   journal April 2010
Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda journal July 2015
A fidelity mechanism in DNA polymerase lambda promotes error‐free bypass of 8‐oxo‐ dG journal July 2016
A Structural Solution for the DNA Polymerase λ-Dependent Repair of DNA Gaps with Minimal Homology journal February 2004
Role of the catalytic metal during polymerization by DNA polymerase lambda journal September 2007
Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide journal November 2014
Observing a DNA Polymerase Choose Right from Wrong journal July 2013
Capture of a third Mg2+ is essential for catalyzing DNA synthesis journal June 2016
Time-lapse crystallography snapshots of a double-strand break repair polymerase in action journal August 2017
Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction journal May 2018
Watching DNA polymerase η make a phosphodiester bond journal July 2012
Time-Dependent Extension from an 8-Oxoguanine Lesion by Human DNA Polymerase Beta journal July 2017
Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography journal April 2015
Capturing a mammalian DNA polymerase extending from an oxidized nucleotide journal April 2017
Replication infidelity via a mismatch with Watson–Crick geometry journal January 2011
Cation trafficking propels RNA hydrolysis journal August 2018
Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase λ journal November 2010
A study of the mechanism of DNA polymerase I from Escherichia coli with diastereomeric phosphorothioate analogs of deoxyadenosine triphosphate. journal August 1979
Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction journal July 2017
Stability constants of magnesium and cadmium complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of magnesium-ATP and magnesium-ADP journal October 1984
DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion journal December 2012
Catalytic mechanism of human DNA polymerase λ with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies journal November 2008
Energy analysis of chemistry for correct insertion by DNA polymerase beta journal August 2006
Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity journal December 2002
Genetical Implications of the Structure of Deoxyribonucleic Acid journal May 1953
Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes journal March 2015
Dynamic basis for dG•dT misincorporation via tautomerization and ionization journal January 2018
Structural insights into the translational infidelity mechanism journal June 2015
Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis journal October 2011
Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity journal April 2016
The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β journal September 2014
Rev1 Employs a Novel Mechanism of DNA Synthesis Using a Protein Template journal September 2005
Structural Insights into DNA Polymerase β Deterrents for Misincorporation Support an Induced-Fit Mechanism for Fidelity journal October 2004
Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction journal May 2013
Revealing the role of the product metal in DNA polymerase β catalysis journal January 2017
Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse journal September 2015
Structural principles for the inhibition of the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates journal March 1998
Watching a DNA polymerase in action journal January 2014
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide journal April 2021
Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites journal December 2016
The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ journal May 2012
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes journal July 2006
Features and development of Coot journal March 2010
CheckMyMetal : a macromolecular metal-binding validation tool journal February 2017

Similar Records

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
Journal Article · Tue Apr 06 00:00:00 EDT 2021 · Nature Communications · OSTI ID:1900624

Observing a DNA Polymerase Choose Right from Wrong
Journal Article · Mon Sep 23 00:00:00 EDT 2013 · Cell · OSTI ID:1900624

Hidden Likelihood Support in Genomic Data: Can Forty-Five Wrongs Make a Right?
Journal Article · Wed Jun 01 00:00:00 EDT 2005 · Systematic Biology · OSTI ID:1900624

Related Subjects