Effective antiviral coatings for deactivating SARS-CoV-2 virus on N95 respirator masks or filters

Paranthaman, Mariappan Parans; Peroutka-Bigus, Nathan; Larsen, Kristina R.; Phadke, Kruttika S.; Summers, Tina; Theodore, Merlin; Hensley, Dale K.; Levine, Alan M.; Lee, Richard J.; Bellaire, Bryan H.

doi:10.1016/j.mtadv.2022.100228

Effective antiviral coatings for deactivating SARS-CoV-2 virus on N95 respirator masks or filters

Journal Article · Tue Mar 08 00:00:00 EST 2022 · Materials Today Advances

DOI:https://doi.org/10.1016/j.mtadv.2022.100228· OSTI ID:1888943

^[1]; Peroutka-Bigus, Nathan ^[2]; ^[2]; Phadke, Kruttika S. ^[2]; ^[1]; ^[1]; ^[1]; Levine, Alan M. ^[3]; Lee, Richard J. ^[3]; Bellaire, Bryan H. ^[2]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Iowa State Univ., Ames, IA (United States)
RJ Lee Group, Inc., Monroeville, PA (United States)

The application of antiviral coatings to masks and respirators is a potential mitigating step toward reducing viral transmission during the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic. The use of appropriate masks, social distancing, and vaccines is the immediate solution for limiting the viral spread and protecting people from this virus. N95 respirator masks are effective in filtering the virus particles, but they cannot kill or deactivate the virus. We report a possible approach to deactivating SARS-CoV-2 by applying an antimicrobial coating (Goldshield 75) to masks and respirators, rendering them suitable for repeated use. Masks coated with Goldshield 75 demonstrated continuous inactivation of the Alpha and Beta variants of the SARS-CoV-2 over a 3-day period and no loss of inactivation when stored at temperatures at 50 °C.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1888943

Journal Information:: Materials Today Advances, Journal Name: Materials Today Advances Journal Issue: 1 Vol. 14; ISSN 2590-0498

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (20)

Progress and Perspective of Antiviral Protective Material Zhou, Jialiang; Hu, Zexu; Zabihi, Fatemeh Advanced Fiber Materials, Vol. 2, Issue 3 https://doi.org/10.1007/s42765-020-00047-7	journal	June 2020
In vitro evaluation of a novel process for reducing bacterial contamination of environmental surfaces Baxa, Dwayne; Shetron-Rama, Lynne; Golembieski, Marisabel American Journal of Infection Control, Vol. 39, Issue 6 https://doi.org/10.1016/j.ajic.2010.10.015	journal	August 2011
Evaluation and quantitative microbial risk assessment of a unique antimicrobial agent for hospital surface treatment Perez, Vanessa; Mena, Kristina D.; Watson, Heather N. American Journal of Infection Control, Vol. 43, Issue 11 https://doi.org/10.1016/j.ajic.2015.06.013	journal	November 2015
The potential exposure and hazards of copper nanoparticles: A review Ameh, Thelma; Sayes, Christie M. Environmental Toxicology and Pharmacology, Vol. 71 https://doi.org/10.1016/j.etap.2019.103220	journal	October 2019
Decontamination interventions for the reuse of surgical mask personal protective equipment: a systematic review Zorko, D. J.; Gertsman, S.; O'Hearn, K. Journal of Hospital Infection, Vol. 106, Issue 2 https://doi.org/10.1016/j.jhin.2020.07.007	journal	October 2020
Virucidal effect against coronavirus SARS-CoV-2 of a silver nanocluster/silica composite sputtered coating Balagna, Cristina; Perero, Sergio; Percivalle, Elena Open Ceramics, Vol. 1 https://doi.org/10.1016/j.oceram.2020.100006	journal	May 2020
Polymer, Additives, and Processing Effects on N95 Filter Performance Larsen, Gregory S.; Cheng, Yongqiang; Daemen, Luke L. ACS Applied Polymer Materials, Vol. 3, Issue 2 https://doi.org/10.1021/acsapm.0c01294	journal	January 2021
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters Port, Julia R.; Yinda, Claude Kwe; Owusu, Irene Offei Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-25156-8	journal	August 2021
Intranasal Delivery of Copper Oxide Nanoparticles Induces Pulmonary Toxicity and Fibrosis in C57BL/6 mice Lai, Xiaofeng; Zhao, Hu; Zhang, Yong Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-22556-7	journal	March 2018
Stability of SARS-CoV-2 on critical personal protective equipment Kasloff, Samantha B.; Leung, Anders; Strong, James E. Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-020-80098-3	journal	January 2021
A comprehensive review on antimicrobial face masks: an emerging weapon in fighting pandemics Pullangott, Gayathri; Kannan, Uthradevi; S., Gayathri RSC Advances, Vol. 11, Issue 12 https://doi.org/10.1039/D0RA10009A	journal	January 2021
Recharging and rejuvenation of decontaminated N95 masks Hossain, Emroj; Bhadra, Satyanu; Jain, Harsh Physics of Fluids, Vol. 32, Issue 9 https://doi.org/10.1063/5.0023940	journal	September 2020
Application of a quaternary ammonium agent on surgical face masks before use for pre-decontamination of nosocomial infection-related bioaerosols Tseng, Chun-Chieh; Pan, Zih-Ming; Chang, Chih-Hui Aerosol Science and Technology, Vol. 50, Issue 3 https://doi.org/10.1080/02786826.2016.1140895	journal	January 2016
Effectiveness of Face Masks in Preventing Airborne Transmission of SARS-CoV-2 Ueki, Hiroshi; Furusawa, Yuri; Iwatsuki-Horimoto, Kiyoko mSphere, Vol. 5, Issue 5 https://doi.org/10.1128/mSphere.00637-20	journal	October 2020
SARS-CoV-2 and the role of fomite transmission: a systematic review Onakpoya, Igho J.; Heneghan, Carl J.; Spencer, Elizabeth A. F1000Research, Vol. 10 https://doi.org/10.12688/f1000research.51590.1	journal	March 2021
Evaluation of bactericidal and anti-biofilm properties of a novel surface-active organosilane biocide against healthcare associated pathogens and Pseudomonas aeruginosa biolfilm Murray, Jason; Muruko, Tendai; Gill, Chris I. R. PLOS ONE, Vol. 12, Issue 8 https://doi.org/10.1371/journal.pone.0182624	journal	August 2017
Science-Based Strategies of Antiviral Coatings with Viricidal Properties for the COVID-19 Like Pandemics Pemmada, Rakesh; Zhu, Xiaoxian; Dash, Madhusmita Materials, Vol. 13, Issue 18 https://doi.org/10.3390/ma13184041	journal	September 2020
Silver Nanoparticles Biosynthesis, Characterization, Antimicrobial Activities, Applications, Cytotoxicity and Safety Issues: An Updated Review Bamal, Deepak; Singh, Anoop; Chaudhary, Gaurav Nanomaterials, Vol. 11, Issue 8 https://doi.org/10.3390/nano11082086	journal	August 2021
Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis Martí, Miguel; Tuñón-Molina, Alberto; Aachmann, Finn Polymers, Vol. 13, Issue 2 https://doi.org/10.3390/polym13020207	journal	January 2021
Copper-Coated Polypropylene Filter Face Mask with SARS-CoV-2 Antiviral Ability Jung, Sunghoon; Yang, Jun-Yeoung; Byeon, Eun-Yeon Polymers, Vol. 13, Issue 9 https://doi.org/10.3390/polym13091367	journal	April 2021

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36 MATERIALS SCIENCE
Alpha and beta variants
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Effective antiviral coatings for deactivating SARS-CoV-2 virus on N95 respirator masks or filters

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