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Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase

Journal Article · · Biochemistry
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Research Organization:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1880656
Report Number(s):
BNL-221065-0001-JACI
Journal Information:
Biochemistry, Vol. 59, Issue 29
Country of Publication:
United States
Language:
English

References (37)

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Farnesyl Diphosphate Synthase:  The Art of Compromise between Substrate Selectivity and Stereoselectivity journal November 2006
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Undecaprenyl diphosphate synthase, a cis -prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis journal April 2012
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Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs journal February 2006
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design journal November 2005
Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer journal September 2009
Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase journal July 2012
Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates journal February 2014
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Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II. journal April 1994
Conversion from Archaeal Geranylgeranyl Diphosphate Synthase to Farnesyl Diphosphate Synthase journal February 1997
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Conversion from Farnesyl Diphosphate Synthase to Geranylgeranyl Diphosphate Synthase by Random Chemical Mutagenesis journal April 1996
A Role of the Amino Acid Residue Located on the Fifth Position before the First Aspartate-rich Motif of Farnesyl Diphosphate Synthase on Determination of the Final Product journal November 1996
Conversion of Product Specificity of Archaebacterial Geranylgeranyl-diphosphate Synthase journal August 1996
Protein Design of Geranyl Diphosphate Synthase. Strutural Features That Define the Product Specificities of Prenyltransferases journal September 1999
Regulation of product chain length by isoprenyl diphosphate synthases journal December 1996
Farnesyl pyrophosphate synthase is essential for the promastigote and amastigote stages in Leishmania major journal June 2019
Pyridinium-1-yl Bisphosphonates Are Potent Inhibitors of Farnesyl Diphosphate Synthase and Bone Resorption journal March 2005
Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs journal June 2020
Farnesyl Diphosphate Synthase Is a Cytosolic Enzyme in Leishmania major Promastigotes and Its Overexpression Confers Resistance to Risedronate journal July 2006
High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery journal December 2001
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery journal September 2004
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[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
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In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates journal December 2015

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