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Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores

Journal Article · · Redox Biology
Not Available
Sponsoring Organization:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI ID:
1877707
Journal Information:
Redox Biology, Journal Name: Redox Biology Journal Issue: C Vol. 55; ISSN 2213-2317
Publisher:
ElsevierCopyright Statement
Country of Publication:
Netherlands
Language:
English

References (69)

Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function: Impaired contractility in iron-deficient cardiomyocytes journal February 2018
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury journal July 2008
Decreased Hepatocyte Autophagy Leads to Synergistic IL‐1β and TNF Mouse Liver Injury and Inflammation journal June 2020
Sex‐Specific Regulation of Interferon‐γ Cytotoxicity in Mouse Liver by Autophagy journal August 2021
A precious metal: Iron, an essential nutrient for all cells journal March 2006
Iron-induced generation of mitochondrial ROS depends on AMPK activity journal June 2017
Iron in Health and Disease: An Update journal September 2019
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress journal March 2003
The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes journal February 2020
Lipid-Induced Endoplasmic Reticulum Stress Impairs Selective Autophagy at the Step of Autophagosome-Lysosome Fusion in Hepatocytes journal July 2016
Activation of apoptosis signalling pathways by reactive oxygen species journal December 2016
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis journal April 2015
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death journal May 2012
A Red Carpet for Iron Metabolism journal January 2017
Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart journal October 2015
Roles of Fe–S proteins: from cofactor synthesis to iron homeostasis to protein synthesis journal June 2016
Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis journal October 2021
Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin journal April 2022
Iron chelators induce autophagic cell death in multiple myeloma cells journal August 2014
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy journal October 2006
Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest journal June 2011
Role of Mitochondria in Ferroptosis journal January 2019
Iron depletion increases manganese uptake and potentiates apoptosis through ER stress journal September 2013
Mitochondrial iron–sulfur clusters: Structure, function, and an emerging role in vascular biology journal November 2021
Ferroptosis is an autophagic cell death process journal August 2016
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy journal March 2014
ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner journal May 2017
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer journal May 2021
Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts journal August 2019
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling journal December 2011
Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice journal February 2016
Ferroptosis as a target for protection against cardiomyopathy journal January 2019
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance journal April 2019
Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats journal February 2002
C/EBP Homologous Protein (CHOP) Contributes to Suppression of Metabolic Genes during Endoplasmic Reticulum Stress in the Liver journal February 2013
Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity journal December 2013
Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production journal December 2002
Production of Reactive Oxygen Species by Mitochondria: CENTRAL ROLE OF COMPLEX III journal July 2003
Acute loss of iron–sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells journal March 2018
A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling journal October 2019
ER stress: Autophagy induction, inhibition and selection journal November 2015
Autophagy promotes ferroptosis by degradation of ferritin journal June 2016
Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A journal July 2016
Lysosome calcium in ROS regulation of autophagy journal August 2016
Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons journal September 2017
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 journal January 2021
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals journal May 2017
ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo journal May 2008
Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival journal July 2014
Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content journal March 2012
NEW EMBO MEMBERS' REVIEW: Lysosomal cysteine proteases: facts and opportunities journal September 2001
Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα‐dependent manner journal November 2018
Overview of iron metabolism in health and disease: Iron metabolism in health and disease journal March 2017
TFEB Links Autophagy to Lysosomal Biogenesis journal May 2011
Identification of the Iron-Responsive Element for the Translational Regulation of Human Ferritin mRNA journal December 1987
Systemic Iron Homeostasis journal October 2013
Iron Overload Damages the Endothelial Mitochondria via the ROS/ADMA/DDAHII/eNOS/NO Pathway journal November 2019
Intralysosomal Iron Induces Lysosomal Membrane Permeabilization and Cathepsin D–Mediated Cell Death in Trabecular Meshwork Cells Exposed to Oxidative Stress journal December 2010
Effects of maternal iron status on placental and fetal iron homeostasis journal December 2019
Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss journal August 2015
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity journal May 2020
Chronic Palmitate But Not Oleate Exposure Induces Endoplasmic Reticulum Stress, Which May Contribute to INS-1 Pancreatic β-Cell Apoptosis journal July 2006
Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease journal March 2012
Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification journal May 2016
The integrated stress response journal August 2016
Iron overload inhibits late stage autophagic flux leading to insulin resistance journal August 2019
Current understanding of iron homeostasis journal October 2017
Dissecting the dynamic turnover of GFP-LC3 in the autolysosome journal February 2011
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo journal December 2019

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