We report that due to their high gyromagnetic ratio, there is considerable interest in measuring distances and correlations involving protons, but such measurements are compounded by the simultaneous recoupling of chemical shift anisotropy (CSA). This secondary recoupling adds additional modulations to the signal intensities that ultimately lead to t1-noise and signal decay. Recently, Venkatesh et al. demonstrated that the addition of CSA refocusing periods during 1H-X dipolar recoupling led to sequences with far higher stability and performance. Herein, we describe a related effort and develop a symmetry-based recoupling sequence that continually refocuses the 1H CSA. This sequence shows superior performance to the regular and t1-noise eliminated D-HMQC sequences in the case of spin-1/2 nuclei and comparable performance to the later for half-integer quadrupoles.
Perras, Frédéric A., et al. "<em>t</em><sub>1</sub>-noise elimination by continuous chemical shift anisotropy refocusing." Solid State Nuclear Magnetic Resonance, vol. 120, Jun. 2022. https://doi.org/10.1016/j.ssnmr.2022.101807
Perras, Frédéric A., Goh, Tian Wei, & Huang, Wenyu (2022). <em>t</em><sub>1</sub>-noise elimination by continuous chemical shift anisotropy refocusing. Solid State Nuclear Magnetic Resonance, 120. https://doi.org/10.1016/j.ssnmr.2022.101807
Perras, Frédéric A., Goh, Tian Wei, and Huang, Wenyu, "<em>t</em><sub>1</sub>-noise elimination by continuous chemical shift anisotropy refocusing," Solid State Nuclear Magnetic Resonance 120 (2022), https://doi.org/10.1016/j.ssnmr.2022.101807
@article{osti_1873414,
author = {Perras, Frédéric A. and Goh, Tian Wei and Huang, Wenyu},
title = {<em>t</em><sub>1</sub>-noise elimination by continuous chemical shift anisotropy refocusing},
annote = {We report that due to their high gyromagnetic ratio, there is considerable interest in measuring distances and correlations involving protons, but such measurements are compounded by the simultaneous recoupling of chemical shift anisotropy (CSA). This secondary recoupling adds additional modulations to the signal intensities that ultimately lead to t1-noise and signal decay. Recently, Venkatesh et al. demonstrated that the addition of CSA refocusing periods during 1H-X dipolar recoupling led to sequences with far higher stability and performance. Herein, we describe a related effort and develop a symmetry-based recoupling sequence that continually refocuses the 1H CSA. This sequence shows superior performance to the regular and t1-noise eliminated D-HMQC sequences in the case of spin-1/2 nuclei and comparable performance to the later for half-integer quadrupoles.},
doi = {10.1016/j.ssnmr.2022.101807},
url = {https://www.osti.gov/biblio/1873414},
journal = {Solid State Nuclear Magnetic Resonance},
issn = {ISSN 0926-2040},
volume = {120},
place = {United States},
publisher = {Elsevier},
year = {2022},
month = {06}}