Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae

Sunkavalli, Ashwini; McClure, Ryan; Genco, Caroline

doi:10.3390/microorganisms10050922

Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae

Journal Article · Thu Apr 28 00:00:00 EDT 2022 · Microorganisms

DOI:https://doi.org/10.3390/microorganisms10050922· OSTI ID:1868034

^[1]; McClure, Ryan ^[2]; Genco, Caroline ^[1]

Tufts Univ., Boston, MA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection (STI) gonorrhea, with an estimated 87 million annual cases worldwide. N. gonorrhoeae predominantly colonizes the male and female genital tract (FGT). In the FGT, N. gonorrhoeae confronts fluctuating levels of nutrients and oxidative and non-oxidative antimicrobial defenses of the immune system, as well as the resident microbiome. One mechanism utilized by N. gonorrhoeae to adapt to this dynamic FGT niche is to modulate gene expression primarily through DNA-binding transcriptional regulators. Here, we describe the major N. gonorrhoeae transcriptional regulators, genes under their control, and how these regulatory processes lead to pathogenic properties of N. gonorrhoeae during natural infection. We also discuss the current knowledge of the structure, function, and diversity of the FGT microbiome and its influence on gonococcal survival and transcriptional responses orchestrated by its DNA-binding regulators. We conclude with recent multi-omics data and modeling tools and their application to FGT microbiome dynamics. Understanding the strategies utilized by N. gonorrhoeae to regulate gene expression and their impact on the emergent characteristics of this pathogen during infection has the potential to identify new effective strategies to both treat and prevent gonorrhea.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1868034

Report Number(s):: PNNL-SA-172593

Journal Information:: Microorganisms, Journal Name: Microorganisms Journal Issue: 5 Vol. 10; ISSN 2076-2607

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

References (161)

Vaginal microbiome: normalcy vs dysbiosis Saraf, Viqar Sayeed; Sheikh, Sohail Aslam; Ahmad, Aftab Archives of Microbiology, Vol. 203, Issue 7 https://doi.org/10.1007/s00203-021-02414-3	journal	June 2021
Modulation effect of vaginal mucosal microflora and susceptibility to Neisseria gonorrhoeae infections: a systematic review and meta-analysis Zeng, Jingxin; Yang, Ridong; He, Wanping Archives of Gynecology and Obstetrics, Vol. 300, Issue 2 https://doi.org/10.1007/s00404-019-05200-1	journal	June 2019
Comparison of Amsel criteria, Nugent score, culture and two CE-IVD marked quantitative real-time PCRs with microbiota analysis for the diagnosis of bacterial vaginosis van den Munckhof, Ellen H. A.; van Sitter, Rosalie L.; Boers, Kim E. European Journal of Clinical Microbiology & Infectious Diseases, Vol. 38, Issue 5 https://doi.org/10.1007/s10096-019-03538-7	journal	March 2019
Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit Franasiak, J. M.; Werner, M. D.; Juneau, C. R. Journal of Assisted Reproduction and Genetics, Vol. 33, Issue 1 https://doi.org/10.1007/s10815-015-0614-z	journal	November 2015
Lactobacillus crispatus and its enolase and glutamine synthetase influence interactions between Neisseria gonorrhoeae and human epithelial cells Płaczkiewicz, Jagoda; Chmiel, Paulina; Malinowska, Ewelina Journal of Microbiology, Vol. 58, Issue 5 https://doi.org/10.1007/s12275-020-9505-9	journal	April 2020
Presence of antibodies to the major anaerobically induced gonococcal outer membrane protein in sera from patients with gonococcal infections Clark, Virginia L.; Knapp, Joan S.; Thompson, Sumner Microbial Pathogenesis, Vol. 5, Issue 5 https://doi.org/10.1016/0882-4010(88)90038-1	journal	November 1988
Bacterial iron homeostasis Andrews, Simon C.; Robinson, Andrea K.; Rodríguez-Quiñones, Francisco FEMS Microbiology Reviews, Vol. 27, Issue 2-3 https://doi.org/10.1016/S0168-6445(03)00055-X	journal	June 2003
The FUR (ferric uptake regulator) superfamily: Diversity and versatility of key transcriptional regulators Fillat, María F. Archives of Biochemistry and Biophysics, Vol. 546 https://doi.org/10.1016/j.abb.2014.01.029	journal	March 2014
Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women Mitchell, Caroline M.; Haick, Anoria; Nkwopara, Evangelyn American Journal of Obstetrics and Gynecology, Vol. 212, Issue 5 https://doi.org/10.1016/j.ajog.2014.11.043	journal	May 2015
Evidence that the endometrial microbiota has an effect on implantation success or failure Moreno, Inmaculada; Codoñer, Francisco M.; Vilella, Felipe American Journal of Obstetrics and Gynecology, Vol. 215, Issue 6 https://doi.org/10.1016/j.ajog.2016.09.075	journal	December 2016
Influence of sexual intercourse on genital tract microbiota in infertile couples Borovkova, Natalja; Korrovits, Paul; Ausmees, Kristo Anaerobe, Vol. 17, Issue 6 https://doi.org/10.1016/j.anaerobe.2011.04.015	journal	December 2011
Iron availability and infection Weinberg, Eugene D. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1790, Issue 7 https://doi.org/10.1016/j.bbagen.2008.07.002	journal	July 2009
Nutritional immunity beyond iron: a role for manganese and zinc Kehl-Fie, Thomas E.; Skaar, Eric P. Current Opinion in Chemical Biology, Vol. 14, Issue 2 https://doi.org/10.1016/j.cbpa.2009.11.008	journal	April 2010
Iron in Infection and Immunity Cassat, James E.; Skaar, Eric P. Cell Host & Microbe, Vol. 13, Issue 5 https://doi.org/10.1016/j.chom.2013.04.010	journal	May 2013
Computational biology approaches for mapping transcriptional regulatory networks Saint-André, Violaine Computational and Structural Biotechnology Journal, Vol. 19 https://doi.org/10.1016/j.csbj.2021.08.028	journal	January 2021
The Urinary Tract Microbiome in Health and Disease Aragón, Isabel M.; Herrera-Imbroda, Bernardo; Queipo-Ortuño, María I. European Urology Focus, Vol. 4, Issue 1 https://doi.org/10.1016/j.euf.2016.11.001	journal	January 2018
Investigation of the microbiota of the reproductive tract in women undergoing a total hysterectomy and bilateral salpingo-oopherectomy Miles, Shana M.; Hardy, Britney L.; Merrell, D. Scott Fertility and Sterility, Vol. 107, Issue 3 https://doi.org/10.1016/j.fertnstert.2016.11.028	journal	March 2017
Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract Anahtar, Melis N.; Byrne, Elizabeth H.; Doherty, Kathleen E. Immunity, Vol. 42, Issue 5 https://doi.org/10.1016/j.immuni.2015.04.019	journal	May 2015
Changes in the six most common sequence types of Neisseria gonorrhoeae, including ST4378, identified by surveillance of antimicrobial resistance in northern Taiwan from 2006 to 2013 Cheng, Ching-Wai; Li, Lan-Hui; Su, Chen-Yi Journal of Microbiology, Immunology and Infection, Vol. 49, Issue 5 https://doi.org/10.1016/j.jmii.2014.08.016	journal	October 2016
Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae Wu, Hsing-Ju; Seib, Kate L.; Srikhanta, Yogitha N. Journal of Proteomics, Vol. 73, Issue 5 https://doi.org/10.1016/j.jprot.2009.12.001	journal	March 2010
Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections Hickey, D. K.; Patel, M. V.; Fahey, J. V. Journal of Reproductive Immunology, Vol. 88, Issue 2 https://doi.org/10.1016/j.jri.2011.01.005	journal	March 2011
Transcript analysis of nrrF, a Fur repressed sRNA of Neisseria gonorrhoeae Ducey, Thomas F.; Jackson, Lydgia; Orvis, Joshua Microbial Pathogenesis, Vol. 46, Issue 3 https://doi.org/10.1016/j.micpath.2008.12.003	journal	March 2009
Microbiota of male genital tract: Impact on the health of man and his partner Mändar, Reet Pharmacological Research, Vol. 69, Issue 1 https://doi.org/10.1016/j.phrs.2012.10.019	journal	March 2013
Ferric uptake regulation protein acts as a repressor, employing iron(II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli Bagg, Anne; Neilands, J. B. Biochemistry, Vol. 26, Issue 17 https://doi.org/10.1021/bi00391a039	journal	August 1987
Structure, function and diversity of the healthy human microbiome No authors listed Nature, Vol. 486, Issue 7402, p. 207-214 https://doi.org/10.1038/nature11234	journal	June 2012
A perspective on 16S rRNA operational taxonomic unit clustering using sequence similarity Nguyen, Nam-Phuong; Warnow, Tandy; Pop, Mihai npj Biofilms and Microbiomes, Vol. 2, Issue 1 https://doi.org/10.1038/npjbiofilms.2016.4	journal	April 2016
Neisseria gonorrhoeae host adaptation and pathogenesis Quillin, Sarah Jane; Seifert, H. Steven Nature Reviews Microbiology, Vol. 16, Issue 4 https://doi.org/10.1038/nrmicro.2017.169	journal	February 2018
The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes Srikhanta, Yogitha N.; Fox, Kate L.; Jennings, Michael P. Nature Reviews Microbiology, Vol. 8, Issue 3 https://doi.org/10.1038/nrmicro2283	journal	February 2010
Nutritional immunity: transition metals at the pathogen–host interface Hood, M. Indriati; Skaar, Eric P. Nature Reviews Microbiology, Vol. 10, Issue 8 https://doi.org/10.1038/nrmicro2836	journal	July 2012
Mucosal lactoferrin response to genital tract infections is associated with iron and nutritional biomarkers in young Burkinabé women Roberts, S. A.; Brabin, L.; Diallo, S. European Journal of Clinical Nutrition, Vol. 73, Issue 11 https://doi.org/10.1038/s41430-019-0444-7	journal	June 2019
The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases Chen, Chen; Song, Xiaolei; Wei, Weixia Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00901-0	journal	October 2017
Modelling approaches for studying the microbiome Kumar, Manish; Ji, Boyang; Zengler, Karsten Nature Microbiology, Vol. 4, Issue 8 https://doi.org/10.1038/s41564-019-0491-9	journal	July 2019
Gonorrhoea Unemo, Magnus; Seifert, H. Steven; Hook, Edward W. Nature Reviews Disease Primers, Vol. 5, Issue 1 https://doi.org/10.1038/s41572-019-0128-6	journal	November 2019
The vaginal microbiome and preterm birth Fettweis, Jennifer M.; Serrano, Myrna G.; Brooks, J. Paul Nature Medicine, Vol. 25, Issue 6 https://doi.org/10.1038/s41591-019-0450-2	journal	May 2019
Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy Serrano, Myrna G.; Parikh, Hardik I.; Brooks, J. Paul Nature Medicine, Vol. 25, Issue 6 https://doi.org/10.1038/s41591-019-0465-8	journal	May 2019
The biodiversity Composition of Microbiome in Ovarian Carcinoma Patients Zhou, Bo; Sun, Chaoyang; Huang, Jia Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-018-38031-2	journal	February 2019
Diversity of vaginal microbiome and metabolome during genital infections Ceccarani, Camilla; Foschi, Claudio; Parolin, Carola Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-50410-x	journal	October 2019
Iron homeostasis and management of oxidative stress response in bacteria Cornelis, Pierre; Wei, Qing; Andrews, Simon C. Metallomics, Vol. 3, Issue 6 https://doi.org/10.1039/c1mt00022e	journal	January 2011
Integration host factor is a transcriptional cofactor of pilE in Neisseria gonorrhoeae Hill, Stuart A.; Samuels, D. Scott; Carlson, John H. Molecular Microbiology, Vol. 23, Issue 4 https://doi.org/10.1046/j.1365-2958.1997.2321612.x	journal	February 1997
The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers Cornelissen, Cynthia Nau; Kelley, Meera; Hobbs, Marcia M. Molecular Microbiology, Vol. 27, Issue 3 https://doi.org/10.1046/j.1365-2958.1998.00710.x	journal	February 1998
Phase variation of the gonococcal siderophore receptor FetA: FetA phase variation Carson, Susan D. Biegel; Stone, Barbara; Beucher, Margaret Molecular Microbiology, Vol. 36, Issue 3 https://doi.org/10.1046/j.1365-2958.2000.01873.x	journal	May 2000
Identification of transcription activators that regulate gonococcal adaptation from aerobic to anaerobic or oxygen-limited growth Lissenden, Sarah; Mohan, Sudesh; Overton, Tim Molecular Microbiology, Vol. 37, Issue 4 https://doi.org/10.1046/j.1365-2958.2000.02050.x	journal	August 2000
Vaginal microbiome of reproductive-age women Ravel, J.; Gajer, P.; Abdo, Z. Proceedings of the National Academy of Sciences, Vol. 108, Issue Supplement_1 https://doi.org/10.1073/pnas.1002611107	journal	June 2010
OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Christman, M. F.; Storz, G.; Ames, B. N. Proceedings of the National Academy of Sciences, Vol. 86, Issue 10 https://doi.org/10.1073/pnas.86.10.3484	journal	May 1989
Coordinated Regulation of the Neisseria gonorrhoeae-truncated Denitrification Pathway by the Nitric Oxide-sensitive Repressor, NsrR, and Nitrite-insensitive NarQ-NarP Overton, Tim W.; Whitehead, Rebekah; Li, Ying Journal of Biological Chemistry, Vol. 281, Issue 44 https://doi.org/10.1074/jbc.M607056200	journal	November 2006
Specificity of Metal Sensing: Iron and Manganese Homeostasis in Bacillus subtilis Helmann, John D. Journal of Biological Chemistry, Vol. 289, Issue 41 https://doi.org/10.1074/jbc.R114.587071	journal	August 2014
Defence factors of vaginal lactobacilli Kovachev, S. Critical Reviews in Microbiology, Vol. 44, Issue 1 https://doi.org/10.1080/1040841X.2017.1306688	journal	April 2017
Bacterial Vaginosis Assessed by Gram Stain and Diminished Colonization Resistance to Incident Gonococcal, Chlamydial, and Trichomonal Genital Infection Brotman, Rebecca M.; Klebanoff, Mark A.; Nansel, Tonja R. The Journal of Infectious Diseases, Vol. 202, Issue 12 https://doi.org/10.1086/657320	journal	December 2010
Bottlenecks and Hubs in Inferred Networks Are Important for Virulence in Salmonella typhimurium McDermott, Jason E.; Taylor, Ronald C.; Yoon, Hyunjin Journal of Computational Biology, Vol. 16, Issue 2 https://doi.org/10.1089/cmb.2008.04TT	journal	February 2009
Clinical Neisseria gonorrhoeae Isolates in the United States with Resistance to Azithromycin Possess Mutations in All 23S rRNA Alleles and the mtrR Coding Region Wu, Abel; Buono, Sean; Katz, Kenneth A. Microbial Drug Resistance, Vol. 17, Issue 3 https://doi.org/10.1089/mdr.2010.0199	journal	August 2011
Measuring the diversity of the human microbiota with targeted next-generation sequencing Finotello, Francesca; Mastrorilli, Eleonora; Di Camillo, Barbara Briefings in Bioinformatics https://doi.org/10.1093/bib/bbw119	journal	December 2016
Gene co-expression analysis for functional classification and gene–disease predictions van Dam, Sipko; Võsa, Urmo; van der Graaf, Adriaan Briefings in Bioinformatics https://doi.org/10.1093/bib/bbw139	journal	January 2017
Subversion of nutritional immunity by the pathogenic Neisseriae Cornelissen, Cynthia Nau Pathogens and Disease, Vol. 76, Issue 1 https://doi.org/10.1093/femspd/ftx112	journal	October 2017
An update of the unceasingly growing and diverse AraC/XylS family of transcriptional activators Cortés-Avalos, Daniel; Martínez-Pérez, Noemy; Ortiz-Moncada, Mario A. FEMS Microbiology Reviews, Vol. 45, Issue 5 https://doi.org/10.1093/femsre/fuab020	journal	April 2021
Clue Cells in Bacterial Vaginosis: Immunofluorescent Identification of the Adherent Gram-Negative Bacteria as Gardnerella vaginalis Cook, R. L.; Reid, G.; Pond, D. G. Journal of Infectious Diseases, Vol. 160, Issue 3 https://doi.org/10.1093/infdis/160.3.490	journal	September 1989
The Pathogenesis of Gonococcal Urethritis in Men: Confocal and Immunoelectron Microscopic Analysis of Urethral Exudates from Men Infected with Neisseria gonorrhoeae Apicella, M. A.; Ketterer, M.; Lee, F. K. N. Journal of Infectious Diseases, Vol. 173, Issue 3 https://doi.org/10.1093/infdis/173.3.636	journal	March 1996
UniProt: the universal protein knowledgebase in 2021 Bateman, Alex; Martin, Maria-Jesus; Orchard, Sandra Nucleic Acids Research, Vol. 49, Issue D1 https://doi.org/10.1093/nar/gkaa1100	journal	November 2020
Vaginal Microbiome and Its Relationship to Behavior, Sexual Health, and Sexually Transmitted Diseases Lewis, Felicia M. T.; Bernstein, Kyle T.; Aral, Sevgi O. Obstetrics & Gynecology, Vol. 129, Issue 4 https://doi.org/10.1097/AOG.0000000000001932	journal	January 2017
Subclinical Pelvic Inflammatory Disease and Infertility Wiesenfeld, Harold C.; Hillier, Sharon L.; Meyn, Leslie A. Obstetrics & Gynecology, Vol. 120, Issue 1 https://doi.org/10.1097/AOG.0b013e31825a6bc9	journal	January 2012
Multi-omic Microbiome Profiles in the Female Reproductive Tract in Early Pregnancy Jean, Sophonie; Huang, Bernice; Parikh, Hardik I. Infectious Microbes and Diseases, Vol. 1, Issue 2 https://doi.org/10.1097/IM9.0000000000000007	journal	January 2019
The Incidence and Correlates of Symptomatic and Asymptomatic Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Selected Populations in Five Countries Detels, Roger; Green, Annette M.; Klausner, Jeffrey D. Sexually Transmitted Diseases, Vol. 38, Issue 6 https://doi.org/10.1097/OLQ.0b013e318206c288	journal	January 2011
Association Between Trichomonas vaginalis and Vaginal Bacterial Community Composition Among Reproductive-Age Women Brotman, Rebecca M.; Bradford, L. Latey; Conrad, Melissa Sexually Transmitted Diseases, Vol. 39, Issue 10 https://doi.org/10.1097/OLQ.0b013e3182631c79	journal	January 2012
Response of gonococcal clinical isolates to acidic conditions Pettit, R. K.; Mcallister, S. C.; Hamer, Traci A. Journal of Medical Microbiology, Vol. 48, Issue 2 https://doi.org/10.1099/00222615-48-2-149	journal	February 1999
Phase variable DNA repeats in Neisseria gonorrhoeae influence transcription, translation, and protein sequence variation Zelewska, Marta A.; Pulijala, Madhuri; Spencer-Smith, Russell Microbial Genomics, Vol. 2, Issue 8 https://doi.org/10.1099/mgen.0.000078	journal	August 2016
Loop structures in the 5′ untranslated region and antisense RNA mediate pilE gene expression in Neisseria gonorrhoeae Masters, Thao L.; Wachter, Jenny; Hill, Stuart A. Microbiology, Vol. 162, Issue 11 https://doi.org/10.1099/mic.0.000369	journal	November 2016
Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria Barth, K. R.; Isabella, V. M.; Clark, V. L. Microbiology, Vol. 155, Issue 12 https://doi.org/10.1099/mic.0.032961-0	journal	September 2009
cis- and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae Isabella, V.; Wright, L. F.; Barth, K. Microbiology, Vol. 154, Issue 1 https://doi.org/10.1099/mic.0.2007/010470-0	journal	January 2008
Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods Zhou, Xia; Bent, Stephen J.; Schneider, Maria G. Microbiology, Vol. 150, Issue 8 https://doi.org/10.1099/mic.0.26905-0	journal	August 2004
Why do lactobacilli dominate the human vaginal microbiota? Witkin, Ss; Linhares, Im BJOG: An International Journal of Obstetrics & Gynaecology, Vol. 124, Issue 4 https://doi.org/10.1111/1471-0528.14390	journal	November 2016
Metal limitation and toxicity at the interface between host and pathogen Becker, Kyle W.; Skaar, Eric P. FEMS Microbiology Reviews, Vol. 38, Issue 6 https://doi.org/10.1111/1574-6976.12087	journal	November 2014
Innate and adaptive immunity in female genital tract: cellular responses and interactions Wira, Charles R.; Fahey, John V.; Sentman, Charles L. Immunological Reviews, Vol. 206, Issue 1 https://doi.org/10.1111/j.0105-2896.2005.00287.x	journal	August 2005
NmlR of Neisseria gonorrhoeae : a novel redox responsive transcription factor from the MerR family Kidd, Stephen P.; Potter, Adam J.; Apicella, Michael A. Molecular Microbiology, Vol. 57, Issue 6 https://doi.org/10.1111/j.1365-2958.2005.04773.x	journal	August 2005
The transcriptome response of Neisseria gonorrhoeae to hydrogen peroxide reveals genes with previously uncharacterized roles in oxidative damage protection : Gonococcal response to hydrogen peroxide Stohl, Elizabeth A.; Criss, Alison K.; Seifert, H. Steven Molecular Microbiology, Vol. 58, Issue 2 https://doi.org/10.1111/j.1365-2958.2005.04839.x	journal	September 2005
PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae Wu, Hsing-Ju; Seib, Kate L.; Srikhanta, Yogitha N. Molecular Microbiology, Vol. 60, Issue 2 https://doi.org/10.1111/j.1365-2958.2006.05079.x	journal	April 2006
Characterization of the OxyR regulon of Neisseria gonorrhoeae Seib, Kate L.; Wu, Hsing-Ju; Srikhanta, Yogitha N. Molecular Microbiology, Vol. 63, Issue 1 https://doi.org/10.1111/j.1365-2958.2006.05478.x	journal	January 2007
Functional analysis of NsrR, a nitric oxide-sensing Rrf2 repressor in Neisseria gonorrhoeae Isabella, Vincent M.; Lapek Jr, John D.; Kennedy, Edward M. Molecular Microbiology, Vol. 71, Issue 1 https://doi.org/10.1111/j.1365-2958.2008.06522.x	journal	January 2009
Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination Sheikh, Md. Arif; Taylor, Garry L. Molecular Microbiology, Vol. 72, Issue 5 https://doi.org/10.1111/j.1365-2958.2009.06718.x	journal	June 2009
The DNA-binding activity of the Neisseria gonorrhoeae LexA orthologue NG1427 is modulated by oxidation: Inactivation of the gonococcal LexA orthologue by oxidation Schook, Paul O. P.; Stohl, Elizabeth A.; Criss, Alison K. Molecular Microbiology, Vol. 79, Issue 4 https://doi.org/10.1111/j.1365-2958.2010.07491.x	journal	December 2010
Genome plasticity in Neisseria gonorrhoeae Gibbs, Carol P.; Meyer, Thomas F. FEMS Microbiology Letters, Vol. 145, Issue 2 https://doi.org/10.1111/j.1574-6968.1996.tb08574.x	journal	December 1996
Epithelial Cells in the Female Reproductive Tract: a Central Role as Sentinels of Immune Protection: SENTINELS OF THE REPRODUCTIVE TRACT Wira, Charles R.; Grant-Tschudy, Katherine S.; Crane-Godreau, Margaret A. American Journal of Reproductive Immunology, Vol. 53, Issue 2 https://doi.org/10.1111/j.1600-0897.2004.00248.x	journal	February 2005
Evolution of simple sequence repeat-mediated phase variation in bacterial genomes: Bayliss & Palmer Bayliss, Christopher D.; Palmer, Michael E. Annals of the New York Academy of Sciences, Vol. 1267, Issue 1 https://doi.org/10.1111/j.1749-6632.2012.06584.x	journal	September 2012
Temporal Dynamics of the Human Vaginal Microbiota Gajer, P.; Brotman, R. M.; Bai, G. Science Translational Medicine, Vol. 4, Issue 132 https://doi.org/10.1126/scitranslmed.3003605	journal	May 2012
Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914) Su, Xiao-Hong; Wang, Bao-Xi; Le, Wen-Jing Antimicrobial Agents and Chemotherapy, Vol. 60, Issue 1 https://doi.org/10.1128/AAC.01211-15	journal	October 2015
MpeR Regulates the mtr Efflux Locus in Neisseria gonorrhoeae and Modulates Antimicrobial Resistance by an Iron-Responsive Mechanism Mercante, Alexandra Dubon; Jackson, Lydgia; Johnson, Paul J. T. Antimicrobial Agents and Chemotherapy, Vol. 56, Issue 3 https://doi.org/10.1128/AAC.06112-11	journal	March 2012
Phase and Antigenic Variation in Bacteria van der Woude, M. W.; Baumler, A. J. Clinical Microbiology Reviews, Vol. 17, Issue 3 https://doi.org/10.1128/CMR.17.3.581-611.2004	journal	July 2004
The Molecular Mechanisms Used by Neisseria gonorrhoeae To Initiate Infection Differ between Men and Women Edwards, J. L.; Apicella, M. A. Clinical Microbiology Reviews, Vol. 17, Issue 4 https://doi.org/10.1128/CMR.17.4.965-981.2004	journal	October 2004
Inhibition of Neisseria gonorrhoeae Epithelial Cell Interactions by Vaginal Lactobacillus Species Spurbeck, Rachel R.; Arvidson, Cindy Grove Infection and Immunity, Vol. 76, Issue 7 https://doi.org/10.1128/IAI.00101-08	journal	July 2008
This Is Not Your Mother's Repressor: the Complex Role of Fur in Pathogenesis Carpenter, B. M.; Whitmire, J. M.; Merrell, D. S. Infection and Immunity, Vol. 77, Issue 7 https://doi.org/10.1128/IAI.00116-09	journal	April 2009
Neisseria gonorrhoeae Evades Calprotectin-Mediated Nutritional Immunity and Survives Neutrophil Extracellular Traps by Production of TdfH Jean, Sophonie; Juneau, Richard A.; Criss, Alison K. Infection and Immunity, Vol. 84, Issue 10 https://doi.org/10.1128/IAI.00319-16	journal	October 2016
A Strain-Specific Catalase Mutation and Mutation of the Metal-Binding Transporter Gene mntC Attenuate Neisseria gonorrhoeae In Vivo but Not by Increasing Susceptibility to Oxidative Killing by Phagocytes Wu, Hong; Soler-García, Ángel A.; Jerse, Ann E. Infection and Immunity, Vol. 77, Issue 3 https://doi.org/10.1128/IAI.00825-08	journal	March 2009
Lactobacillus jensenii Surface-Associated Proteins Inhibit Neisseria gonorrhoeae Adherence to Epithelial Cells Spurbeck, Rachel R.; Arvidson, Cindy Grove Infection and Immunity, Vol. 78, Issue 7 https://doi.org/10.1128/IAI.01200-09	journal	July 2010
Metal Binding Specificity of the MntABC Permease of Neisseria gonorrhoeae and Its Influence on Bacterial Growth and Interaction with Cervical Epithelial Cells Lim, Karen H. L.; Jones, Christopher E.; vanden Hoven, Rachel N. Infection and Immunity, Vol. 76, Issue 8 https://doi.org/10.1128/IAI.01725-07	journal	August 2008
The Iron-Repressed, AraC-Like Regulator MpeR Activates Expression of fetA in Neisseria gonorrhoeae Hollander, Aimee; Mercante, Alexandra Dubon; Shafer, William M. Infection and Immunity, Vol. 79, Issue 12 https://doi.org/10.1128/IAI.05806-11	journal	September 2011
OxyR Acts as a Repressor of Catalase Expression in Neisseria gonorrhoeae Tseng, H. -J.; McEwan, A. G.; Apicella, M. A. Infection and Immunity, Vol. 71, Issue 1 https://doi.org/10.1128/IAI.71.1.550-556.2003	journal	January 2003
Characterization of the Neisseria gonorrhoeae Iron and Fur Regulatory Network Yu, Chunxiao; McClure, Ryan; Nudel, Kathleen Journal of Bacteriology, Vol. 198, Issue 16 https://doi.org/10.1128/JB.00166-16	journal	May 2016
Fur-Mediated Global Regulatory Circuits in Pathogenic Neisseria Species Yu, Chunxiao; Genco, Caroline Attardo Journal of Bacteriology, Vol. 194, Issue 23 https://doi.org/10.1128/JB.00262-12	journal	August 2012
Transcriptional and Functional Analysis of the Neisseria gonorrhoeae Fur Regulon Jackson, L. A.; Ducey, T. F.; Day, M. W. Journal of Bacteriology, Vol. 192, Issue 1 https://doi.org/10.1128/JB.00741-09	journal	October 2009
Identification and Characterization of Novel Helicobacter pylori apo-Fur-Regulated Target Genes Carpenter, B. M.; Gilbreath, J. J.; Pich, O. Q. Journal of Bacteriology, Vol. 195, Issue 24 https://doi.org/10.1128/JB.01026-13	journal	October 2013
A Novel Fur- and Iron-Regulated Small RNA, NrrF, Is Required for Indirect Fur-Mediated Regulation of the sdhA and sdhC Genes in Neisseria meningitidis Mellin, J. R.; Goswami, Sulip; Grogan, Susan Journal of Bacteriology, Vol. 189, Issue 10 https://doi.org/10.1128/JB.01890-06	journal	May 2007
Glutamine Synthetase and Glucose-6-Phosphate Isomerase Are Adhesive Moonlighting Proteins of Lactobacillus crispatus Released by Epithelial Cathelicidin LL-37 Kainulainen, V.; Loimaranta, V.; Pekkala, A. Journal of Bacteriology, Vol. 194, Issue 10 https://doi.org/10.1128/JB.06704-11	journal	March 2012
Regulation of mtrF Expression in Neisseria gonorrhoeae and Its Role in High-Level Antimicrobial Resistance Folster, J. P.; Shafer, W. M. Journal of Bacteriology, Vol. 187, Issue 11 https://doi.org/10.1128/JB.187.11.3713-3720.2005	journal	May 2005
Identification of the Iron-Responsive Genes of Neisseria gonorrhoeae by Microarray Analysis in Defined Medium Ducey, Thomas F.; Carson, Matthew B.; Orvis, Joshua Journal of Bacteriology, Vol. 187, Issue 14 https://doi.org/10.1128/JB.187.14.4865-4874.2005	journal	July 2005
Gonococcal transferrin-binding protein 1 is required for transferrin utilization and is homologous to TonB-dependent outer membrane receptors Cornelissen, C. N.; Biswas, G. D.; Tsai, J. Journal of Bacteriology, Vol. 174, Issue 18 https://doi.org/10.1128/jb.174.18.5788-5797.1992	journal	September 1992
Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation Nugent, R. P.; Krohn, M. A.; Hillier, S. L. Journal of Clinical Microbiology, Vol. 29, Issue 2 https://doi.org/10.1128/jcm.29.2.297-301.1991	journal	February 1991
Metatranscriptome Analysis of the Vaginal Microbiota Reveals Potential Mechanisms for Protection against Metronidazole in Bacterial Vaginosis Deng, Zhi-Luo; Gottschick, Cornelia; Bhuju, Sabin mSphere, Vol. 3, Issue 3 https://doi.org/10.1128/mSphereDirect.00262-18	journal	June 2018
Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women Nudel, Kathleen; McClure, Ryan; Moreau, Matthew mSphere, Vol. 3, Issue 3 https://doi.org/10.1128/mSphereDirect.00312-18	journal	June 2018
Metabolic Model-Based Integration of Microbiome Taxonomic and Metabolomic Profiles Elucidates Mechanistic Links between Ecological and Metabolic Variation Noecker, Cecilia; Eng, Alexander; Srinivasan, Sujatha mSystems, Vol. 1, Issue 1 https://doi.org/10.1128/mSystems.00013-15	journal	December 2015
Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response Quillin, Sarah J.; Hockenberry, Adam J.; Jewett, Michael C. mSystems, Vol. 3, Issue 5 https://doi.org/10.1128/mSystems.00156-18	journal	October 2018
Global Network Analysis of Neisseria gonorrhoeae Identifies Coordination between Pathways, Processes, and Regulators Expressed during Human Infection McClure, Ryan; Sunkavalli, Ashwini; Balzano, Phillip M. mSystems, Vol. 5, Issue 1 https://doi.org/10.1128/mSystems.00729-19	journal	February 2020
Antimicrobial Resistance Expressed by Neisseria gonorrhoeae: A Major Global Public Health Problem in the 21st Century Unemo, Magnus; del Rio, Carlos; Shafer, William M. Microbiology Spectrum, Vol. 4, Issue 3 https://doi.org/10.1128/microbiolspec.EI10-0009-2015	journal	June 2016
Scanning electron microscopy and freeze-etching of gonorrhoeal urethral exudate. Farzadegan, H.; Roth, I. L. Sexually Transmitted Infections, Vol. 51, Issue 2 https://doi.org/10.1136/sti.51.2.83	journal	April 1975
Acid stress upregulated outer membrane proteins in clinical isolates of Neisseria gonorrhoeae , but not most commensal Neisseria Pettit, R. K.; Whelan, T. M.; Woo, K. S. Canadian Journal of Microbiology, Vol. 47, Issue 9 https://doi.org/10.1139/w01-087	journal	September 2001
The Genetics of Neisseria Species Rotman, Ella; Seifert, H. Steven Annual Review of Genetics, Vol. 48, Issue 1 https://doi.org/10.1146/annurev-genet-120213-092007	journal	November 2014
Transition Metals and Virulence in Bacteria Palmer, Lauren D.; Skaar, Eric P. Annual Review of Genetics, Vol. 50, Issue 1 https://doi.org/10.1146/annurev-genet-120215-035146	journal	November 2016
Neisseria gonorrhoeae : Drug Resistance, Mouse Models, and Vaccine Development Rice, Peter A.; Shafer, William M.; Ram, Sanjay Annual Review of Microbiology, Vol. 71, Issue 1 https://doi.org/10.1146/annurev-micro-090816-093530	journal	September 2017
Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial Pathogens Seib, Kate L.; Srikhanta, Yogitha N.; Atack, John M. Annual Review of Microbiology, Vol. 74, Issue 1 https://doi.org/10.1146/annurev-micro-090817-062346	journal	September 2020
Extragenital Infections Caused by Chlamydia trachomatis and Neisseria gonorrhoeae : A Review of the Literature Chan, Philip A.; Robinette, Ashley; Montgomery, Madeline Infectious Diseases in Obstetrics and Gynecology, Vol. 2016 https://doi.org/10.1155/2016/5758387	journal	January 2016
Nutritional Immunity: Starving Pathogens of Trace Minerals Hennigar, Stephen R.; McClung, James P. American Journal of Lifestyle Medicine, Vol. 10, Issue 3 https://doi.org/10.1177/1559827616629117	journal	February 2016
Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae Isabella, Vincent M.; Clark, Virginia L. BMC Genomics, Vol. 12, Issue 1 https://doi.org/10.1186/1471-2164-12-51	journal	January 2011
Strain-specific differences in Neisseria gonorrhoeae associated with the phase variable gene repertoire Jordan, Philip W.; Snyder, Lori AS; Saunders, Nigel J. BMC Microbiology, Vol. 5, Issue 1 https://doi.org/10.1186/1471-2180-5-21	journal	April 2005
Integrated next-generation sequencing of 16S rDNA and metaproteomics differentiate the healthy urine microbiome from asymptomatic bacteriuria in neuropathic bladder associated with spinal cord injury Fouts, Derrick E.; Pieper, Rembert; Szpakowski, Sebastian Journal of Translational Medicine, Vol. 10, Issue 1 https://doi.org/10.1186/1479-5876-10-174	journal	August 2012
Visualizing metabolic network dynamics through time-series metabolomic data Buchweitz, Lea F.; Yurkovich, James T.; Blessing, Christoph BMC Bioinformatics, Vol. 21, Issue 1 https://doi.org/10.1186/s12859-020-3415-z	journal	July 2020
Emerging azithromycin-resistance among the Neisseria gonorrhoeae strains isolated in Hungary Brunner, Alexandra; Nemes-Nikodem, Eva; Jeney, Csaba Annals of Clinical Microbiology and Antimicrobials, Vol. 15, Issue 1 https://doi.org/10.1186/s12941-016-0166-9	journal	September 2016
Dynamic interaction network inference from longitudinal microbiome data Lugo-Martinez, Jose; Ruiz-Perez, Daniel; Narasimhan, Giri Microbiome, Vol. 7, Issue 1 https://doi.org/10.1186/s40168-019-0660-3	journal	April 2019
Large-Scale Mapping and Validation of Escherichia coli Transcriptional Regulation from a Compendium of Expression Profiles Faith, Jeremiah J.; Hayete, Boris; Thaden, Joshua T. PLoS Biology, Vol. 5, Issue 1 https://doi.org/10.1371/journal.pbio.0050008	journal	January 2007
“Guilt by Association” Is the Exception Rather Than the Rule in Gene Networks Gillis, Jesse; Pavlidis, Paul PLoS Computational Biology, Vol. 8, Issue 3 https://doi.org/10.1371/journal.pcbi.1002444	journal	March 2012
Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial Vaginosis Srinivasan, Sujatha; Liu, Congzhou; Mitchell, Caroline M. PLoS ONE, Vol. 5, Issue 4 https://doi.org/10.1371/journal.pone.0010197	journal	April 2010
Characteristic Male Urine Microbiomes Associate with Asymptomatic Sexually Transmitted Infection Nelson, David E.; Van Der Pol, Barbara; Dong, Qunfeng PLoS ONE, Vol. 5, Issue 11 https://doi.org/10.1371/journal.pone.0014116	journal	November 2010
The Microbial Communities in Male First Catch Urine Are Highly Similar to Those in Paired Urethral Swab Specimens Dong, Qunfeng; Nelson, David E.; Toh, Evelyn PLoS ONE, Vol. 6, Issue 5 https://doi.org/10.1371/journal.pone.0019709	journal	May 2011
Bacterial Communities of the Coronal Sulcus and Distal Urethra of Adolescent Males Nelson, David E.; Dong, Qunfeng; Van Der Pol, Barbara PLoS ONE, Vol. 7, Issue 5 https://doi.org/10.1371/journal.pone.0036298	journal	May 2012
The Potential of Metatranscriptomics for Identifying Screening Targets for Bacterial Vaginosis Twin, Jimmy; Bradshaw, Catriona S.; Garland, Suzanne M. PLoS ONE, Vol. 8, Issue 9 https://doi.org/10.1371/journal.pone.0076892	journal	September 2013
Neisseria gonorrhoeae Modulates Iron-Limiting Innate Immune Defenses in Macrophages Zughaier, Susu M.; Kandler, Justin L.; Shafer, William M. PLoS ONE, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pone.0087688	journal	January 2014
Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae Gong, Zheng; Tang, M. Matt; Wu, Xueliang PLOS ONE, Vol. 11, Issue 1 https://doi.org/10.1371/journal.pone.0147637	journal	January 2016
High-dimensional linear state space models for dynamic microbial interaction networks Chen, Iris; Kelkar, Yogeshwar D.; Gu, Yu PLOS ONE, Vol. 12, Issue 11 https://doi.org/10.1371/journal.pone.0187822	journal	November 2017
The bacterial microbiota in first-void urine from men with and without idiopathic urethritis Frølund, Maria; Wikström, Arne; Lidbrink, Peter PLOS ONE, Vol. 13, Issue 7 https://doi.org/10.1371/journal.pone.0201380	journal	July 2018
Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria Srikhanta, Yogitha N.; Dowideit, Stefanie J.; Edwards, Jennifer L. PLoS Pathogens, Vol. 5, Issue 4 https://doi.org/10.1371/journal.ppat.1000400	journal	April 2009
‘‘Guilt by Association’’ Is the Exception Rather Than the Rule in Gene Networks Jesse, Gillis; Paul, Pavlidis University of British Columbia https://doi.org/10.14288/1.0363483	dataset	January 2018
Genome‐scale metabolic modeling reveals key features of a minimal gene set Lachance, Jean‐Christophe; Matteau, Dominick; Brodeur, Joëlle Molecular Systems Biology, Vol. 17, Issue 7 https://doi.org/10.15252/msb.202010099	journal	July 2021
Evaluation of the composition of the microbiota of the urethra in men with sexually transmitted infections [Оценка микробиоты соскоба уретры у мужчин с инфекциями, передаваемыми половым путем] Rakhmatulina, M. R. Rakhmatulina; Boldyreva, M. N. Boldyreva; Lipova, E. V. Lipova Urologiia, Vol. 6_2020 https://doi.org/10.18565/urology.2019.6.31-37	journal	January 2020
The fallopian tube microbiome: implications for reproductive health Pelzer, Elise S.; Willner, Dana; Buttini, Melissa Oncotarget, Vol. 9, Issue 30 https://doi.org/10.18632/oncotarget.25059	journal	April 2018
Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016 Rowley, Jane; Vander Hoorn, Stephen; Korenromp, Eline Bulletin of the World Health Organization, Vol. 97, Issue 8 https://doi.org/10.2471/BLT.18.228486	journal	June 2019
Neisseria gonorrhoeae Strain with Reduced Susceptibilities to Extended-Spectrum Cephalosporins Nguyen, Duylinh; Gose, Severin; Castro, Lina Emerging Infectious Diseases, Vol. 20, Issue 7 https://doi.org/10.3201/eid2007.131396	journal	July 2014
Vaginal Lactobacilli Reduce Neisseria gonorrhoeae Viability through Multiple Strategies: An in Vitro Study Foschi, Claudio; Salvo, Melissa; Cevenini, Roberto Frontiers in Cellular and Infection Microbiology, Vol. 7 https://doi.org/10.3389/fcimb.2017.00502	journal	December 2017
Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities Redelinghuys, Mathys J.; Geldenhuys, Janri; Jung, Hyunsul Frontiers in Cellular and Infection Microbiology, Vol. 10 https://doi.org/10.3389/fcimb.2020.00354	journal	August 2020
The Microbiome Composition of a Man's Penis Predicts Incident Bacterial Vaginosis in His Female Sex Partner With High Accuracy Mehta, Supriya D.; Zhao, Dan; Green, Stefan J. Frontiers in Cellular and Infection Microbiology, Vol. 10 https://doi.org/10.3389/fcimb.2020.00433	journal	August 2020
The Microbiome as a Key Regulator of Female Genital Tract Barrier Function Plesniarski, Andrew; Siddik, Abu Bakar; Su, Ruey-Chyi Frontiers in Cellular and Infection Microbiology, Vol. 11 https://doi.org/10.3389/fcimb.2021.790627	journal	December 2021
The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development Tan, Aimee; Atack, John M.; Jennings, Michael P. Frontiers in Immunology, Vol. 7 https://doi.org/10.3389/fimmu.2016.00586	journal	December 2016
The Unique Microbiome and Innate Immunity During Pregnancy Mei, Chunlei; Yang, Weina; Wei, Xin Frontiers in Immunology, Vol. 10 https://doi.org/10.3389/fimmu.2019.02886	journal	December 2019
The Pathobiology of Neisseria gonorrhoeae Lower Female Genital Tract Infection Edwards, Jennifer L.; Butler, Emily K. Frontiers in Microbiology, Vol. 2 https://doi.org/10.3389/fmicb.2011.00102	journal	January 2011
TonB-Dependent Transporters Expressed by Neisseria gonorrhoeae Cornelissen, Cynthia Nau; Hollander, Aimee Frontiers in Microbiology, Vol. 2 https://doi.org/10.3389/fmicb.2011.00117	journal	January 2011
Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis Aldunate, Muriel; Srbinovski, Daniela; Hearps, Anna C. Frontiers in Physiology, Vol. 6 https://doi.org/10.3389/fphys.2015.00164	journal	June 2015
Finding a Balance in the Vaginal Microbiome: How Do We Treat and Prevent the Occurrence of Bacterial Vaginosis? Joseph, Rebecca Jane; Ser, Hooi-Leng; Kuai, Yi-He Antibiotics, Vol. 10, Issue 6 https://doi.org/10.3390/antibiotics10060719	journal	June 2021
K-Module Algorithm: An Additional Step to Improve the Clustering Results of WGCNA Co-Expression Networks Hou, Jie; Ye, Xiufen; Li, Chuanlong Genes, Vol. 12, Issue 1 https://doi.org/10.3390/genes12010087	journal	January 2021
Bacterial Colonization of the Female Upper Genital Tract Peric, Adriana; Weiss, Jürgen; Vulliemoz, Nicolas International Journal of Molecular Sciences, Vol. 20, Issue 14 https://doi.org/10.3390/ijms20143405	journal	July 2019
Computational Modeling of the Human Microbiome Chowdhury, Shomeek; Fong, Stephen S. Microorganisms, Vol. 8, Issue 2 https://doi.org/10.3390/microorganisms8020197	journal	January 2020
Utility of Next-generation sequencing in Managing Bacterial Vaginosis: Examples from Clinical Practice Gd, Bostwick; Ca, Hunt Journal of Women's Health Care, Vol. 5, Issue 4 https://doi.org/10.4172/2167-0420.1000322	journal	January 2016
The Urinary Tract Microbiome in Male Genitourinary Diseases: Focusing on Benign Prostate Hyperplasia and Lower Urinary Tract Symptoms Kim, Myung Soo; Jung, Seung Il International Neurourology Journal, Vol. 25, Issue 1 https://doi.org/10.5213/inj.2040174.087	journal	March 2021
Emerging azithromycin-resistance among the Neisseria gonorrhoeae strains isolated in Hungary Brunner, Alexandra; Nemes-Nikodem, Eva; Jeney, Csaba Figshare https://doi.org/10.6084/m9.figshare.c.3604523.v1	collection	January 2016
Dynamic interaction network inference from longitudinal microbiome data Lugo-Martinez, Jose; Ruiz-Perez, Daniel; Narasimhan, Giri Figshare https://doi.org/10.6084/m9.figshare.c.4456979	collection	January 2019
Visualizing metabolic network dynamics through time-series metabolomic data Buchweitz, Lea F.; Yurkovich, James T.; Blessing, Christoph figshare https://doi.org/10.6084/m9.figshare.c.4925334.v1	collection	January 2020
Gonococcal Infections Hook, Edward W. Annals of Internal Medicine, Vol. 102, Issue 2 https://doi.org/10.7326/0003-4819-102-2-229	journal	February 1985

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Feale genital tract
Neisseria
Neisseria gonorrhoeae
RNA-sequencing
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microbiome
microbiome modeling
network analysis
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