Comprehensive view of microscopic interactions between DNA-coated colloids

Cui, Fan; Marbach, Sophie; Zheng, Jeana Aojie; Holmes-Cerfon, Miranda; Pine, David J.

doi:10.1038/s41467-022-29853-w

Comprehensive view of microscopic interactions between DNA-coated colloids

Journal Article · Thu Apr 28 00:00:00 EDT 2022 · Nature Communications

DOI:https://doi.org/10.1038/s41467-022-29853-w· OSTI ID:1865503

Cui, Fan; Marbach, Sophie; Zheng, Jeana Aojie; ;

Abstract

The self-assembly of DNA-coated colloids into highly-ordered structures offers great promise for advanced optical materials. However, control of disorder, defects, melting, and crystal growth is hindered by the lack of a microscopic understanding of DNA-mediated colloidal interactions. Here we use total internal reflection microscopy to measure in situ the interaction potential between DNA-coated colloids with nanometer resolution and the macroscopic melting behavior. The range and strength of the interaction are measured and linked to key material design parameters, including DNA sequence, polymer length, grafting density, and complementary fraction. We present a first-principles model that screens and combines existing theories into one coherent framework and quantitatively reproduces our experimental data without fitting parameters over a wide range of DNA ligand designs. Our theory identifies a subtle competition between DNA binding and steric repulsion and accurately predicts adhesion and melting at a molecular level. Combining experimental and theoretical results, our work provides a quantitative and predictive approach for guiding material design with DNA-nanotechnology and can be further extended to a diversity of colloidal and biological systems.

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Research Organization:: New York Univ. (NYU), NY (United States)

Sponsoring Organization:: National Science Foundation (NSF); US Army Research Office (ARO); USDOE; USDOE Office of Science (SC)

Grant/Contract Number:: SC0007991; SC0012296

OSTI ID:: 1865503

Alternate ID(s):: OSTI ID: 1904503

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 13; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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71 CLASSICAL AND QUANTUM MECHANICS
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77 NANOSCIENCE AND NANOTECHNOLOGY
colloids
organizing material with DNA
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Comprehensive view of microscopic interactions between DNA-coated colloids

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