Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Pre- and post-treatment image-based dosimetry in 90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit

Journal Article · · Physics in Medicine and Biology
 [1];  [2];  [3];  [1];  [4];  [1];  [1]
  1. Massachusetts General Hospital, Boston, MA (United States); Harvard Medical School, Boston, MA (United States)
  2. Massachusetts General Hospital, Boston, MA (United States)
  3. Massachusetts General Hospital, Boston, MA (United States); Harvard Medical School, Boston, MA (United States); Eidgenoessische Technische Hochschule (ETH), Zurich (Switzerland)
  4. SLAC National Accelerator Lab., Menlo Park, CA (United States)
+ Show Author Affiliations
Objective.To evaluate the pre-treatment and post-treatment imaging-based dosimetry of patients treated with 90Y-microspheres, including accurate estimations of dose to tumor, healthy liver and lung. To do so, the Monte Carlo (MC) TOPAS platform is in this work extended towards its utilization in radionuclide therapy. Approach. In this study, five patients treated at the Massachusetts General Hospital were selected for this study. All patients had data for both pre-treatment SPECT-CT imaging using 99mTc-MAA as a surrogate of the 90Y-microspheres treatment and SPECT-CT imaging immediately after the 90Y activity administration. Pre- and post-treatment doses were computed with TOPAS using the SPECT images to localize the source positions and the CT images to account for tissue inhomoegeneities. We compared our results with analytical calculations following the voxel-based MIRD scheme. Main results. TOPAS results largely agreed with the MIRD-based calculations in soft tissue regions: the average difference in mean dose to the liver was 0.14 Gy GBq-1 (2.6%). However, dose distributions in the lung differed considerably: absolute differences in mean doses to the lung ranged from 1.2 to 6.3 Gy GBq-1 and relative differences from 153% to 231%. We also found large differences in the intra-hepatic dose distributions between pre- and post-treatment imaging, but only limited differences in the pulmonary dose. Significance. Doses to lung were found to be higher using TOPAS with respect to analytical calculations which may significantly underestimate dose to the lung, suggesting the use of MC methods for 90Y dosimetry. According to our results, pre-treatment imaging may still be representative of dose to lung in these treatments.
Research Organization:
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
Sponsoring Organization:
National Cancer Institute (NCI); National Institutes of Health (NIH); USDOE
Grant/Contract Number:
AC02-76SF00515
OSTI ID:
1865365
Journal Information:
Physics in Medicine and Biology, Journal Name: Physics in Medicine and Biology Journal Issue: 24 Vol. 66; ISSN 0031-9155
Publisher:
IOP PublishingCopyright Statement
Country of Publication:
United States
Language:
English

References (46)

Yttrium‐90 Radioembolization for the Treatment of Solitary, Unresectable HCC: The LEGACY Study journal June 2021
Quantification of internal dosimetry in PET patients: individualized Monte Carlo vs generic phantom‐based calculations journal July 2020
SIRT of liver metastases: physiological and pathophysiological considerations journal July 2012
Clinical impact of 99mTc-MAA SPECT/CT-based dosimetry in the radioembolization of liver malignancies with 90Y-loaded microspheres journal September 2015
Identifying Aberrant Hepatic Arteries Prior to Intra-arterial Radioembolization journal January 2014
Geant4—a simulation toolkit
  • Agostinelli, S.; Allison, J.; Amako, K.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 506, Issue 3 https://doi.org/10.1016/S0168-9002(03)01368-8
journal July 2003
Validation of the TOPAS Monte Carlo toolkit for HDR brachytherapy simulations journal July 2021
A guide to 90Y radioembolization and its dosimetry journal December 2019
The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research journal April 2020
Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium journal May 2007
Early Dose Response to Yttrium-90 Microsphere Treatment of Metastatic Liver Cancer by a Patient-Specific Method Using Single Photon Emission Computed Tomography and Positron Emission Tomography journal May 2009
Patient Selection and Activity Planning Guide for Selective Internal Radiotherapy With Yttrium-90 Resin Microspheres journal January 2012
Radiation Pneumonitis Following Yttrium-90 Radioembolization: Case Report and Literature Review journal May 2012
Tumor Dose Response in Yttrium-90 Resin Microsphere Embolization for Neuroendocrine Liver Metastases: A Tumor-Specific Analysis with Dose Estimation Using SPECT-CT journal November 2017
Recent developments in Geant4
  • Allison, J.; Amako, K.; Apostolakis, J.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 835 https://doi.org/10.1016/j.nima.2016.06.125
journal November 2016
Validation of a dose-point kernel convolution technique for internal dosimetry journal March 1995
Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions journal January 2000
GATE: a simulation toolkit for PET and SPECT journal September 2004
Clinical implementation of full Monte Carlo dose calculation in proton beam therapy journal August 2008
A free database of radionuclide voxel S values for the dosimetry of nonuniform activity distributions journal January 2012
Development and validation of RAYDOSE: a Geant4-based application for molecular radiotherapy journal March 2013
Internal dosimetry with the Monte Carlo code GATE: validation using the ICRP/ICRU female reference computational model journal February 2017
Systematic investigation on the validity of partition model dosimetry for 90 Y radioembolization using Monte Carlo simulation journal August 2017
The microdosimetric extension in TOPAS: development and comparison with published data journal July 2019
Monte Carlo 90 Y PET/CT dosimetry of unexpected focal radiation-induced lung damage after hepatic radioembolisation journal November 2020
Full Monte Carlo internal dosimetry in nuclear medicine by means of GAMOS journal June 2020
VIDA: A Voxel-Based Dosimetry Method for Targeted Radionuclide Therapy Using Geant4 journal February 2015
Decay data for Internal and External dose Assessment journal January 2002
Use of Yttrium-90 Glass Microspheres (TheraSphere) for the Treatment of Unresectable Hepatocellular Carcinoma in Patients with Portal Vein Thrombosis journal April 2004
Prediction of tumor response and patient outcome after radioembolization of hepatocellular carcinoma using 90Y-PET-computed tomography dosimetry journal January 2021
Geant4 developments and applications journal February 2006
Treatment options for unresectable HCC with a focus on SIRT with Yttrium-90 resin microspheres journal July 2017
Recommendations of the American Association of Physicists in Medicine on dosimetry, imaging, and quality assurance procedures for 90 Y microsphere brachytherapy in the treatment of hepatic malignancies: AAPM recommendations 90 Y microsphere brachytherapy journal August 2011
TOPAS: An innovative proton Monte Carlo platform for research and clinical applications: TOPAS: An innovative proton Monte Carlo platform journal October 2012
Safety and efficacy of Y-90 microsphere treatment in patients with primary and metastatic liver cancer: The tumor selectivity of the treatment as a function of tumor to liver flow ratio journal March 2007
Personalized predictive lung dosimetry by technetium-99m macroaggregated albumin SPECT/CT for yttrium-90 radioembolization journal June 2014
The value of 99mTc-MAA SPECT/CT for lung shunt estimation in 90Y radioembolization: a phantom and patient study journal June 2018
Comparing voxel-based absorbed dosimetry methods in tumors, liver, lung, and at the liver-lung interface for 90Y microsphere selective internal radiation therapy journal July 2015
EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres journal November 2021
Standardizing SPECT/CT dosimetry following radioembolization with yttrium-90 microspheres journal October 2021
Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies journal February 2021
Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces journal January 2011
TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology journal January 2018
A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90Y microsphere therapy [A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90Y microsphere therapy] journal April 2015
99m Tc-Macroaggregated Albumin Poorly Predicts the Intrahepatic Distribution of 90 Y Resin Microspheres in Hepatic Radioembolization journal June 2013
Determination of Radiation Absorbed Dose to Primary Liver Tumors and Normal Liver Tissue Using Post-Radioembolization 90Y PET journal October 2014

Similar Records

Lung Dose Calculation With SPECT/CT for {sup 90}Yittrium Radioembolization of Liver Cancer
Journal Article · Thu Feb 28 23:00:00 EST 2013 · International Journal of Radiation Oncology, Biology and Physics · OSTI ID:22224389
SU-F-T-687: Comparison of SPECT/CT-Based Methodologies for Estimating Lung Dose from Y-90 Radioembolization
Journal Article · Wed Jun 15 00:00:00 EDT 2016 · Medical Physics · OSTI ID:22649242
SU-E-T-402: Y-90 Microspheres (SIR Spheres) for Treatment of Liver Metastasis : Technique
Journal Article · Sun Jun 01 00:00:00 EDT 2014 · Medical Physics · OSTI ID:22355944

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
90Y microsphere
internal dosimetry
radioembolization
radionuclides
topas