No difference in the parental origin of susceptibility HLA class II haplotypes among Norwegian patients with insulin-dependent diabetes mellitus

Journal Article · Fri Dec 01 04:00:00 EST 1995 · American Journal of Human Genetics

OSTI ID:186224

Undlien, D E; Akselsen, H E; Thorsby, E ^[1]

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1. National Hospital, Oslo (Norway); and others

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease affecting genetically susceptible individuals. A major part of the genetic risk is encoded by HLA class II genes. Strong susceptibility is conferred by the DRB1*04-DQA1*03-DQB1*0302 (hereafter called {open_quotes}DR4-DQ8{close_quotes}) and the DRBI*0301-DQA1*0501-DQB1*0201 (hereafter called {open_quotes}DR3-DQ2{close_quotes}) haplotypes, particularly when they occur together. In an interesting publication it suggests that IDDM patients inherit DR4 from their fathers and DR3 from their mothers more often than vice versa. This has also been suggested elsewhere. Several different mechanisms have been proposed to explain this observation, such as parental imprinting, fetal loss, and maternal effect associated with the presence of the DR3 antigen in the mother. Several studies have shown that children of fathers with IDDM have a higher risk of IDDM than do children of mothers with IDDM. If there is an effect of the parental origin of HLA class II-encoded IDDM susceptibility, this could potentially explain the difference. 19 refs., 2 tabs.

• OSTI ID: 186224
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: 6 Vol. 57; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
DIABETES MELLITUS
GENE MUTATIONS
GENES
GENETICS
HEREDITARY DISEASES
HISTOCOMPATIBILITY COMPLEX
INSULIN
NORWAY
PATIENTS
RISK ASSESSMENT
SEX DEPENDENCE