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Title: Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction

Journal Article · · Nat. Catalysis

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1855464
Journal Information:
Nat. Catalysis, Vol. 5
Country of Publication:
United States
Language:
ENGLISH

References (40)

New Generation of Biocatalysts for Organic Synthesis journal February 2014
Divergent synthesis of complex diterpenes through a hybrid oxidative approach journal August 2020
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?: Miniperspective journal December 2015
Biocatalytic Methods for CC Bond Formation journal February 2013
Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products journal June 2016
Heterologous expression systems for polyketide synthases journal January 2009
Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution journal October 2001
Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran journal May 2014
Crystallization-induced asymmetric transformations (CIAT): stereoconvergent acid-catalyzed lactonization of substituted 2-amino-4-aryl-4-hydroxybutanoic acids journal June 2005
Preparation of β-hydroxy-α-amino Acid Using Recombinant d -Threonine Aldolase journal August 2015
Overcoming Thermodynamic and Kinetic Limitations of Aldolase-Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations journal February 2007
Broadening the scope of biocatalytic C–C bond formation journal June 2020
Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi journal May 2016
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts journal November 2015
On the catalytic mechanism and stereospecificity of Escherichia coli l -threonine aldolase journal November 2013
Separating Thermodynamics from Kinetics-A New Understanding of the Transketolase Reaction journal April 2017
An efficient and concise entry to (-)-4,5-dihydroxy----norvaline. Formal synthesis of clavalanine. journal April 1991
Unusual Amino Acids in Medicinal Chemistry journal September 2016
Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition–Transamination Reactions journal April 2021
Combining Aldolases and Transaminases for the Synthesis of 2-Amino-4-hydroxybutanoic Acid journal February 2017
Upgrading aminoacyl-tRNA synthetases for genetic code expansion journal October 2018
Discovery of a pathway for terminal-alkyne amino acid biosynthesis journal March 2019
The I-TASSER Suite: protein structure and function prediction journal December 2014
l -Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate journal December 2020
Iterative Saturation Mutagenesis Accelerates Laboratory Evolution of Enzyme Stereoselectivity: Rigorous Comparison with Traditional Methods journal June 2010
Exploring protein fitness landscapes by directed evolution journal December 2009
Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active-Site Saturation Test journal July 2005
Nitroalkanes as Versatile Nucleophiles for Enzymatic Synthesis of Noncanonical Amino Acids journal August 2019
Determination ofD-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene journal January 1984
Proline and hydroxyproline metabolism: implications for animal and human nutrition journal August 2010
Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. III. Absolute stereochemistry. journal January 1983
On the taught new tricks of enzymes immobilization: An all-inclusive overview journal July 2020
Recent advances in whole cell biocatalysis techniques bridging from investigative to industrial scale journal December 2016
Crystal Structure of Human Maspin, a Serpin with Antitumor Properties journal December 2004
Directed molecular evolution by machine learning and the influence of nonlinear interactions journal May 2005
Design of an in vitro biocatalytic cascade for the manufacture of islatravir journal December 2019
Pyridoxal Phosphate Enzymes: Mechanistic, Structural, and Evolutionary Considerations journal June 2004
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues journal July 2017
Engineered Biosynthesis of β-Alkyl Tryptophan Analogues journal October 2018
Enzymatic assembly of DNA molecules up to several hundred kilobases journal April 2009