Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

Wang, Xiaodong; Liu, Jing; Zhang, Weihe; Stashko, Michael A.; Nichols, James; Miley, Michael J.; Norris-Drouin, Jacqueline; Chen, Zhilong; Machius, Mischa; DeRyckere, Deborah; Wood, Edgar; Graham, Douglas K.; Earp, H. Shelton; Kireev, Dmitri; Frye, Stephen V.

doi:10.1021/acsmedchemlett.6b00221

Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

Journal Article · Thu Sep 01 04:00:00 EDT 2016 · ACS Med. Chem. Lett.

DOI:https://doi.org/10.1021/acsmedchemlett.6b00221· OSTI ID:1855446

Wang, Xiaodong; Liu, Jing; Zhang, Weihe; Stashko, Michael A.; Nichols, James; Miley, Michael J.; Norris-Drouin, Jacqueline; Chen, Zhilong; Machius, Mischa; DeRyckere, Deborah; Wood, Edgar; Graham, Douglas K.; Earp, H. Shelton; Kireev, Dmitri; Frye, Stephen V.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; NCI; NIH

OSTI ID:: 1855446

Journal Information:: ACS Med. Chem. Lett., Journal Name: ACS Med. Chem. Lett. Journal Issue: (12) Vol. 7

Country of Publication:: United States

Language:: ENGLISH

References (24)

Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors Zhang, Weihe; Zhang, Dehui; Stashko, Michael A. Journal of Medicinal Chemistry, Vol. 56, Issue 23 https://doi.org/10.1021/jm401387j	journal	November 2013
State-of-the-art of small molecule inhibitors of the TAM family: The point of view of the chemist Baladi, Tom; Abet, Valentina; Piguel, Sandrine European Journal of Medicinal Chemistry, Vol. 105 https://doi.org/10.1016/j.ejmech.2015.10.003	journal	November 2015
Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia Liu, Jing; Yang, Chao; Simpson, Catherine ACS Medicinal Chemistry Letters, Vol. 3, Issue 2 https://doi.org/10.1021/ml200239k	journal	January 2012
Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells Mercer, J.; Helenius, A. Science, Vol. 320, Issue 5875 https://doi.org/10.1126/science.1155164	journal	April 2008
Mer Receptor Tyrosine Kinase Signaling Guttridge, Katherine L.; Luft, J. Christopher; Dawson, Thomas L. Journal of Biological Chemistry, Vol. 277, Issue 27 https://doi.org/10.1074/jbc.M112086200	journal	July 2002
Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties? Giordanetto, Fabrizio; Kihlberg, Jan Journal of Medicinal Chemistry, Vol. 57, Issue 2 https://doi.org/10.1021/jm400887j	journal	September 2013
The exploration of macrocycles for drug discovery — an underexploited structural class Driggers, Edward M.; Hale, Stephen P.; Lee, Jinbo Nature Reviews Drug Discovery, Vol. 7, Issue 7 https://doi.org/10.1038/nrd2590	journal	July 2008
UNC1062, a new and potent Mer inhibitor Liu, Jing; Zhang, Weihe; Stashko, Michael A. European Journal of Medicinal Chemistry, Vol. 65 https://doi.org/10.1016/j.ejmech.2013.03.035	journal	July 2013
Mer Receptor Tyrosine Kinase Wang, Xiaodong; Frye, Stephen Annual Reports in Medicinal Chemistry https://doi.org/10.1016/B978-0-12-800167-7.00019-5	book	January 2014
Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase Cohen, Philip L.; Caricchio, Roberto; Abraham, Valsamma Journal of Experimental Medicine, Vol. 196, Issue 1 https://doi.org/10.1084/jem.20012094	journal	July 2002
Two Simple and Generic Antibody-Independent Kinase Assays: Comparison of a Bioluminescent and a Microfluidic Assay Format Pommereau, Antje; Pap, Everard; Kannt, Aimo Journal of Biomolecular Screening, Vol. 9, Issue 5 https://doi.org/10.1177/1087057104264175	journal	August 2004
The receptor tyrosine kinase MerTK activates phospholipase C γ2 during recognition of apoptotic thymocytes by murine macrophages Todt, Jill C.; Hu, Bin; Curtis, Jeffrey L. Journal of Leukocyte Biology, Vol. 75, Issue 4 https://doi.org/10.1189/jlb.0903439	journal	January 2004
Resident Murine Alveolar and Peritoneal Macrophages Differ in Adhesion of Apoptotic Thymocytes Hu, Bin; Jennings, Jeffrey H.; Sonstein, Joanne American Journal of Respiratory Cell and Molecular Biology, Vol. 30, Issue 5 https://doi.org/10.1165/rcmb.2003-0255OC	journal	May 2004
Macrocycles in new drug discovery Mallinson, Jamie; Collins, Ian Future Medicinal Chemistry, Vol. 4, Issue 11 https://doi.org/10.4155/fmc.12.93	journal	July 2012
The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer Graham, Douglas K.; DeRyckere, Deborah; Davies, Kurtis D. Nature Reviews Cancer, Vol. 14, Issue 12 https://doi.org/10.1038/nrc3847	journal	November 2014
A Chemogenomic Analysis of the Human Proteome: Application to Enzyme Families Bernasconi, Paul; Chen, Min; Galasinski, Scott SLAS Discovery, Vol. 12, Issue 7, p. 972-982 https://doi.org/10.1177/1087057107306759	journal	October 2007
TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine Jemielity, Stephanie; Wang, Jinyize J.; Chan, Ying Kai PLoS Pathogens, Vol. 9, Issue 3 https://doi.org/10.1371/journal.ppat.1003232	journal	March 2013
Phagocytosis and clearance of apoptotic cells is mediated by MER Scott, Rona S.; McMahon, Eileen J.; Pop, Shannon M. Nature, Vol. 411, Issue 6834 https://doi.org/10.1038/35075603	journal	May 2001
UNC2025 , a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor Zhang, Weihe; DeRyckere, Deborah; Hunter, Debra Journal of Medicinal Chemistry, Vol. 57, Issue 16 https://doi.org/10.1021/jm500749d	journal	August 2014
Comparison of diffusion coefficients for matched pairs of macrocyclic and linear molecules over a drug-like molecular weight range Bogdan, Andrew R.; Davies, Nichola L.; James, Keith Organic & Biomolecular Chemistry, Vol. 9, Issue 22 https://doi.org/10.1039/c1ob05996c	journal	January 2011
Molecular Pathways: MERTK Signaling in Cancer Cummings, Christopher T.; DeRyckere, Deborah; Earp, H. Shelton Clinical Cancer Research, Vol. 19, Issue 19 https://doi.org/10.1158/1078-0432.CCR-12-1451	journal	July 2013
Comparison of On-Chip and Off-Chip Microfluidic Kinase Assay Formats Dunne, Jude; Reardon, Holly; Trinh, Vy ASSAY and Drug Development Technologies, Vol. 2, Issue 2 https://doi.org/10.1089/154065804323056468	journal	April 2004
Biology of the TAM Receptors Lemke, G. Cold Spring Harbor Perspectives in Biology, Vol. 5, Issue 11 https://doi.org/10.1101/cshperspect.a009076	journal	November 2013
Apoptotic mimicry: phosphatidylserine-mediated macropinocytosis of vaccinia virus: Viral apoptotic mimicry Mercer, Jason; Helenius, Ari Annals of the New York Academy of Sciences, Vol. 1209, Issue 1 https://doi.org/10.1111/j.1749-6632.2010.05772.x	journal	October 2010

Similar Records

Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

Journal Article · Wed Dec 11 23:00:00 EST 2013 · J. Med. Chem. · OSTI ID:1191741

Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors

Journal Article · Sun Nov 06 23:00:00 EST 2016 · ACS Medicinal Chemistry Letters · OSTI ID:1347772

Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406

Journal Article · Fri Jun 15 00:00:00 EDT 2007 · Toxicology and Applied Pharmacology · OSTI ID:20976955

Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

Citation Formats

References (24)

Similar Records

Related Subjects