Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM)

Book · Sat Jan 01 00:00:00 EST 2022

DOI:https://doi.org/10.1007/978-1-0716-1811-0_23· OSTI ID:1855404

Hollerbach, Adam L. ^[1]; Conant, Christopher R. ^[1]; Nagy, Gavril ^[1]; Ibrahim, Yehia M.  ^[1]

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1. BATTELLE (PACIFIC NW LAB)

Structures for Lossless Ion Manipulations (SLIM) is a powerful variant of traveling wave ion mobility spectrometry (TW-IMS) that uses a serpentine pattern of microelectrodes deposited onto printed circuit boards to achieve ultralong ion path lengths (13.5 m). Ions are propelled through SLIM platforms via arrays of TW electrodes while RF and DC electrodes provide radial confinement, establishing near lossless transmission. The recent ability to cycle ions multiple times through a SLIM has allowed ion path lengths to exceed 1000 m, providing unprecedented separation power and the ability to observe ion structural conformations unobtainable with other IMS technologies. The combination of high separation power, high signal intensity, and the ability to couple with mass spectrometry places SLIM in the unique position of being able to address longstanding proteomics and metabolomics challenges by allowing the characterization of isomeric mixtures containing low abundance analytes.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1855404
• Report Number(s): PNNL-SA-146735
• Resource Relation: Journal Volume: 2394
• Country of Publication: United States
• Language: English