Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes

Franco, Mario E. E.; Wisecaver, Jennifer H.; Arnold, A. Elizabeth; Ju, Yu‐Ming; Slot, Jason C.; Ahrendt, Steven; Moore, Lillian P.; Eastman, Katharine E.; Scott, Kelsey; Konkel, Zachary; Mondo, Stephen J.; Kuo, Alan; Hayes, Richard D.; Haridas, Sajeet; Andreopoulos, Bill; Riley, Robert; LaButti, Kurt; Pangilinan, Jasmyn; Lipzen, Anna; Amirebrahimi, Mojgan; Yan, Juying; Adam, Catherine; Keymanesh, Keykhosrow; Ng, Vivian; Louie, Katherine; Northen, Trent; Drula, Elodie; Henrissat, Bernard; Hsieh, Huei‐Mei; Youens‐Clark, Ken; Lutzoni, François; Miadlikowska, Jolanta; Eastwood, Daniel C.; Hamelin, Richard C.; Grigoriev, Igor V.; U’Ren, Jana M.

doi:10.1111/nph.17873

Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes

Journal Article · Fri Nov 19 00:00:00 EST 2021 · New Phytologist

DOI:https://doi.org/10.1111/nph.17873· OSTI ID:1855208

^[1]; ^[2]; ^[1]; ^[3]; ^[4]; ^[5]; Moore, Lillian P. ^[1]; ^[2]; ^[4]; Konkel, Zachary ^[4]; Mondo, Stephen J. ^[5]; Kuo, Alan ^[5]; ^[5]; ^[5]; Andreopoulos, Bill ^[5]; Riley, Robert ^[5]; ^[5]; Pangilinan, Jasmyn ^[5]; ^[5]; Amirebrahimi, Mojgan ^[5] more »

Univ. of Arizona, Tucson, AZ (United States)
Purdue Univ., West Lafayette, IN (United States)
Academia Sinica, Taipei (Taiwan)
The Ohio State Univ., Columbus, OH (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Aix‐Marseille Univ. (France); INRAE, Marseille (France)
Technical Univ. of Denmark, Lyngby (Denmark); King Abdulaziz Univ., Jeddah (Saudi Arabia)
Duke Univ., Durham, NC (United States)
Swansea Univ. (United Kingdom)
Univ. of British Columbia, Vancouver, BC (Canada)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)

Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their abundance and broad host ranges spanning all lineages of land plants and lichens, suggests that enhanced secondary metabolism might facilitate symbioses with phylogenetically diverse hosts. Here, we examined secondary metabolite gene clusters (SMGCs) across 96 Xylariales genomes in two clades (Xylariaceae s.l. and Hypoxylaceae), including 88 newly sequenced genomes of endophytes and closely related saprotrophs and pathogens. We paired genomic data with extensive metadata on endophyte hosts and substrates, enabling us to examine genomic factors related to the breadth of symbiotic interactions and ecological roles. All genomes contain hyperabundant SMGCs; however, Xylariaceae have increased numbers of gene duplications, horizontal gene transfers (HGTs) and SMGCs. Enhanced metabolic diversity of endophytes is associated with a greater diversity of hosts and increased capacity for lignocellulose decomposition. Our results suggest that, as host and substrate generalists, Xylariaceae endophytes experience greater selection to diversify SMGCs compared with more ecologically specialised Hypoxylaceae species. Altogether, our results provide new evidence that SMGCs may facilitate symbiosis with phylogenetically diverse hosts, highlighting the importance of microbial symbioses to drive fungal metabolic diversity.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1855208

Alternate ID(s):: OSTI ID: 1834427

Journal Information:: New Phytologist, Journal Name: New Phytologist Journal Issue: 3 Vol. 233; ISSN 0028-646X

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes

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References (90)

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