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Optogenetic Amplification Circuits for Light-Induced Metabolic Control

Journal Article · · ACS Synthetic Biology
 [1];  [2];  [2];  [2];  [3];  [4]
  1. Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States; OSTI
  2. Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States
  3. Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States
  4. Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States; The Andlinger Center for Energy and the Environment, Princeton University, Princeton, New Jersey 08544, United States; Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States
Not provided.
Research Organization:
Princeton Univ., NJ (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0019363
OSTI ID:
1853118
Journal Information:
ACS Synthetic Biology, Journal Name: ACS Synthetic Biology Journal Issue: 5 Vol. 10; ISSN 2161-5063
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (27)

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Identification of Natural and Artificial DNA Substrates for Light-Activated LOV–HTH Transcription Factor EL222 journal December 2012
Engineering metabolism through dynamic control journal August 2015
Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast journal September 2016
Establishment of a yeast platform strain for production of p-coumaric acid through metabolic engineering of aromatic amino acid biosynthesis journal September 2015
Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols journal February 2013
An optogenetic gene expression system with rapid activation and deactivation kinetics journal January 2014
Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors journal July 2017
Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics journal May 2015
Controlling Central Carbon Metabolism for Improved Pathway Yields in Saccharomyces cerevisiae journal November 2015
Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters journal May 2012
Current and future modalities of dynamic control in metabolic engineering journal August 2018
Improving Production of Malonyl Coenzyme A-Derived Metabolites by Abolishing Snf1-Dependent Regulation of Acc1 journal May 2014
Layered dynamic regulation for improving metabolic pathway productivity in Escherichia coli journal March 2018
Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering journal November 2020
Production of the antimalarial drug precursor artemisinic acid in engineered yeast journal April 2006
Optogenetic control of the lac operon for bacterial chemical and protein production journal September 2020
Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae journal March 2015
Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications journal August 2016
The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. journal March 1996
Encapsulation of polyphenols – a review journal October 2010
Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein journal May 2011
A Highly Characterized Yeast Toolkit for Modular, Multipart Assembly journal April 2015
Optogenetic regulation of engineered cellular metabolism for microbial chemical production journal March 2018
A LOV2 Domain-Based Optogenetic Tool to Control Protein Degradation and Cellular Function journal April 2013
Variations in Protein–Flavin Hydrogen Bonding in a Light, Oxygen, Voltage Domain Produce Non-Arrhenius Kinetics of Adduct Decay journal September 2011
Bringing Light to Transcription: The Optogenetics Repertoire journal November 2018

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