The Landscape of RNA-Protein Interactions in Plants: Approaches and Current Status

Burjoski, Vesper; Reddy, Anireddy S.  N.

doi:10.3390/ijms22062845

Title: The Landscape of RNA-Protein Interactions in Plants: Approaches and Current Status

Journal Article · Thu Mar 11 00:00:00 EST 2021 · International Journal of Molecular Sciences (Online)

DOI:https://doi.org/10.3390/ijms22062845· OSTI ID:1851431

Burjoski, Vesper ^[1]; Reddy, Anireddy S. N. ^[1]

Colorado State Univ., Fort Collins, CO (United States). Dept. of Biology. Program in Cell and Molecular Biology

RNAs transmit information from DNA to encode proteins that perform all cellular processes and regulate gene expression in multiple ways. From the time of synthesis to degradation, RNA molecules are associated with proteins called RNA-binding proteins (RBPs). The RBPs play diverse roles in many aspects of gene expression including pre-mRNA processing and post-transcriptional and translational regulation. In the last decade, the application of modern techniques to identify RNA–protein interactions with individual proteins, RNAs, and the whole transcriptome has led to the discovery of a hidden landscape of these interactions in plants. Global approaches such as RNA interactome capture (RIC) to identify proteins that bind protein-coding transcripts have led to the identification of close to 2000 putative RBPs in plants. Interestingly, many of these were found to be metabolic enzymes with no known canonical RNA-binding domains. Here, we review the methods used to analyze RNA–protein interactions in plants thus far and highlight the understanding of plant RNA–protein interactions these techniques have provided us. We also review some recent protein-centric, RNA-centric, and global approaches developed with non-plant systems and discuss their potential application to plants. We also provide an overview of results from classical studies of RNA–protein interaction in plants and discuss the significance of the increasingly evident ubiquity of RNA–protein interactions for the study of gene regulation and RNA biology in plants.

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Research Organization:: Colorado State Univ., Fort Collins, CO (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Science Foundation (NSF)

Grant/Contract Number:: SC0010733; DBI-1949036; MCB-2014542

OSTI ID:: 1851431

Journal Information:: International Journal of Molecular Sciences (Online), Vol. 22, Issue 6; ISSN 1422-0067

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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