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Association of human T-cell leukemia virus type 1 with prevalent rheumatoid arthritis among atomic bomb survivors: A cross-sectional study

Journal Article · · Medicine
 [1];  [2];  [3];  [2];  [2];  [4];  [5];  [6]
  1. Nagasaki Univ. (Japan). Radiation Effects Research Foundation. Dept. of Clinical Studies; OSTI
  2. Nagasaki Univ. (Japan). Radiation Effects Research Foundation. Dept. of Clinical Studies
  3. Nagasaki Univ. (Japan). Radiation Effects Research Foundation. Dept. of Statistics
  4. Nagasaki Univ. (Japan). Sasebo Chuo Hospital. Rheumatic and Collagen Disease Center
  5. Nagasaki Univ. (Japan). Graduate School of Biomedical Sciences. Dept. of Immunology and Rheumatology
  6. Nagasaki Univ. (Japan). Graduate School of Biomedical Sciences. Dept. of Immunology and Rheumatology
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Previous studies have suggested that human T-cell leukemia virus type 1 (HTLV-1) might act as a pathogen in rheumatoid arthritis (RA), but epidemiological evidence of an association is scarce. We measured anti-HTLV-1 antibodies among Nagasaki atomic bomb survivors to determine whether HTLV-1 is related to RA and whether radiation exposure is associated with HTLV-1 and RA prevalence. This is a cross-sectional study among atomic bomb survivors who participated in biennial health examinations from 2006 to 2010. Serum levels of anti-HTLV-1 antibodies were measured using a chemiluminescent enzyme immunoassay and confirmed by Western blotting. Association between HTLV-1 and RA was analyzed by a logistic regression model. Of 2091 participants (women 61.5%; median age, 73 years), 215 (10.3%) had anti-HTLV-1 antibodies. HTLV-1 prevalence was higher among women (13.1% vs 5.8%; P<.001). Twenty-two participants (1.1%) were diagnosed with RA. HTLV-1 prevalence among RA participants was significantly higher than that among non-RA participants (27.3% vs 10.1%; P=.020). After adjustment for age, sex, and hepatitis C virus infection, HTLV-1 was significantly associated with prevalent RA (odds ratio, 2.89; 95% confidence interval, 1.06, 7.03). There was no association between radiation dose and either the prevalence of HTLV-1 or RA. This study, among a well-defined group of atomic bomb survivors, suggests that HTLV-1 is associated with RA. Abbreviations: AHS = Adult Health Study, ATL/ATLL = adult T cell leukemia/lymphoma, bioDMARDs = biological disease modifying antirheumatic drugs, CCP = cyclic citrullinated peptide, CI = confidence interval, CLEIA = chemiluminescent enzyme immunoassay, CRP = C-reactive protein, csDMARDs = conventional synthetic disease modifying antirheumatic drugs, Gy = gray, HCV = hepatitis C virus, HTLV-1 = human T-cell leukemia virus type 1, IF = immunofluorescent, RA = rheumatoid arthritis, RERF = Radiation Effects Research Foundation, RF = rheumatoid factor, SS = Sjogren syndrome.
Research Organization:
National Academy of Sciences, Washington, DC (United States)
Sponsoring Organization:
USDOE Office of Environment, Health, Safety and Security (AU)
Grant/Contract Number:
HS0000031
OSTI ID:
1850255
Journal Information:
Medicine, Journal Name: Medicine Journal Issue: 24 Vol. 100; ISSN 0025-7974
Publisher:
Wolters Kluwer Health, Inc.Copyright Statement
Country of Publication:
United States
Language:
English

References (32)

Treatment With Anti-Tumor Necrosis Factor Biologic Agents in Human T Lymphotropic Virus Type I-Positive Patients With Rheumatoid Arthritis: Anti-TNF Therapy in HTLV-I-Positive RA Patients journal April 2014
High seroprevalence of anti–HTLV-I antibody in rheumatoid arthritis journal March 1996
2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative journal August 2010
Current prevalence of HTLV-1 in Japan as determined by screening of blood donors journal December 2011
Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren's syndrome journal October 1994
Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies journal January 2020
Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors journal January 2005
Pathophysiological links between rheumatoid arthritis and the Epstein–Barr virus: An update journal October 2007
Epidemiological studies of atomic bomb radiation at the Radiation Effects Research Foundation journal February 2019
Clinical features and human T-cell leukemia virus type-1 (HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline data in a single center cohort study journal April 2019
A Follow‐Up Study of Morbidity and Mortality Associated with Hepatitis C Virus Infection and Its Interaction with Human T Lymphotropic Virus Type I in Miyazaki, Japan journal January 2000
Human T Lymphotropic Virus Type 1 Infection Influences Hepatitis C Virus Clearance journal November 2001
Bias reduction of maximum likelihood estimates journal January 1993
The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century journal July 2002
DS02R1: Improvements to Atomic Bomb Survivors’ Input Data and Implementation of Dosimetry System 2002 (DS02) and Resulting Changes in Estimated Doses journal January 2017
Human T-Lymphotropic Virus Type-I Infection, Antibody Titers and Cause-specific Mortality among Atomic-bomb Survivors journal August 1998
Mortality of rheumatoid arthritis in Japan: a longitudinal cohort study journal October 2005
Prevalence of Sjogren syndrome among Nagasaki atomic bomb survivors journal August 2007
Association of human T lymphotropic virus type I with Sjögren syndrome: Table 1 journal May 2010
Primary Sjogren's syndrome with antibodies to HTLV-I: clinical and laboratory features. journal June 1992
Infection of human synovial cells by human T cell lymphotropic virus type I. Proliferation and granulocyte/macrophage colony-stimulating factor production by synovial cells. journal October 1993
Low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology journal September 2017
Thyroid Dysfunction and Autoimmune Thyroid Diseases Among Atomic Bomb Survivors Exposed in Childhood journal May 2017
The Prevalence of HTLV-1 and its Co-Infection with HCV, HBV, and HIV in Hemophilic Patients journal September 2015
Anti-Human T-Lymphotropic Virus Type-I Antibodies in Atomic-Bomb Survivors. journal January 1995
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors journal January 2017
T Cells of Atomic Bomb Survivors Respond Poorly to Stimulation by Staphylococcus aureus Toxins In Vitro : Does This Stem from their Peripheral Lymphocyte Populations Having a Diminished Naïve CD4 T-Cell Content? journal December 2002
Use of anti-tumor necrosis factor biologics in the treatment of rheumatoid arthritis does not change human T-lymphotropic virus type 1 markers: a case series journal November 2013
Estimates of the prevalence of and current treatment practices for rheumatoid arthritis in Japan using reimbursement data from health insurance societies and the IORRA cohort (I) journal November 2013
HTLV-1 Infection and Rheumatic Diseases journal February 2020
Rheumatic manifestations of hepatitis C virus chronic infection: Indications for a correct diagnosis journal January 2016
Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives journal May 2010

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
General &amp; Internal Medicine
epidemiology
human T-cell leukemia virus type 1
radiation
rheumatoid arthritis