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Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases

Journal Article · · Bioorg. Med. Chem. Lett.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1847692
Journal Information:
Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Journal Issue: (8) Vol. 28
Country of Publication:
United States
Language:
ENGLISH

References (30)

Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells journal May 2012
Protein kinase CK2 – A key suppressor of apoptosis journal January 2008
Identification of Ellagic Acid as Potent Inhibitor of Protein Kinase CK2:  A Successful Example of a Virtual Screening Application journal March 2006
CK2 Inhibits Apoptosis and Changes Its Cellular Localization Following Ionizing Radiation journal May 2005
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death journal January 2003
CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy journal December 2010
Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization journal February 2012
Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2 journal August 2007
Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: Evaluation of their effects on cells and different molecular forms of human CK2 journal December 2005
Multiple myeloma cell survival relies on high activity of protein kinase CK2 journal September 2006
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor journal December 2011
7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity journal November 2011
Structure-Activity Relationships of Pyrazine-Based CK2 Inhibitors: Synthesis and Evaluation of 2,6-Disubstituted Pyrazines and 4,6-Disubstituted Pyrimidines journal September 2008
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2 journal July 2012
Development and exploitation of CK2 inhibitors journal June 2005
Profiling of Protein Kinases in the Neoplastic Transformation of Human Ovarian Surface Epithelium journal August 2001
Features and potentials of ATP-site directed CK2 inhibitors journal December 2005
Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo journal January 2016
Discovery of a Potent and Selective Protein Kinase CK2 Inhibitor by High-Throughput Docking journal May 2003
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia journal February 2014
Coumarin as Attractive Casein Kinase 2 (CK2) Inhibitor Scaffold: An Integrate Approach To Elucidate the Putative Binding Motif and Explain Structure–Activity Relationships journal February 2008
Casein Kinase 2 Is Activated and Essential for Wnt/β-Catenin Signaling journal July 2006
Protein kinase CK2 phosphorylates and upregulates Akt/PKB journal April 2005
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases journal July 2012
CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response journal October 2003
The Protein Kinase CK2 Phosphorylates SNAP190 to Negatively Regulate SNAPC DNA Binding and Human U6 Transcription by RNA Polymerase III journal September 2007
Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo journal July 2013
ATP Site-Directed Inhibitors of Protein Kinase CK2: An Update journal June 2011
Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth journal July 2009
Inspecting the Structure-Activity Relationship of Protein Kinase CK2 Inhibitors Derived from Tetrabromo-Benzimidazole journal November 2005

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