Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)

Journal Article · · ACS Med. Chem. Lett.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1844738
Journal Information:
ACS Med. Chem. Lett., Vol. 13, Issue (1)
Country of Publication:
United States
Language:
ENGLISH

References (22)

Oncology Meets Immunology: The Cancer-Immunity Cycle journal July 2013
Current Status and Future Directions of the Immune Checkpoint Inhibitors Ipilimumab, Pembrolizumab, and Nivolumab in Oncology journal May 2015
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential journal April 2015
Combination cancer immunotherapy and new immunomodulatory targets journal July 2015
HPK1 as a novel target for cancer immunotherapy journal April 2012
The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function journal October 2018
A perspective on HPK1 as a novel immuno-oncology drug target journal September 2020
Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1 journal February 2021
Identification of Potent Reverse Indazole Inhibitors for HPK1 journal March 2021
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds journal March 2021
Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor journal January 2021
Inhibitors of immuno-oncology target HPK1 – a patent review (2016 to 2020) journal May 2021
The influence of drug-like concepts on decision-making in medicinal chemistry journal November 2007
The role of ligand efficiency metrics in drug discovery journal January 2014
Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis journal August 2009
The Capable ABL: What Is Its Biological Function? journal April 2014
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation journal October 2004
Structure, Regulation, Signaling, and Targeting of Abl Kinases in Cancer journal May 2012
Understanding the Impact of the P-loop Conformation on Kinase Selectivity
  • Guimarães, Cristiano R. W.; Rai, Brajesh K.; Munchhof, Michael J.
  • Journal of Chemical Information and Modeling, Vol. 51, Issue 6 https://doi.org/10.1021/ci200153c
journal May 2011
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer journal January 2019
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET journal December 2020
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD2 receptors CRTH2 and DP journal July 2014