Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies

Boot, Iris W. A.; Wesselius, Anke; Yu, Evan Y. W.; Brinkman, Maree; van den Brandt, Piet; Grant, Eric J.; White, Emily; Weiderpass, Elisabete; Ferrari, Pietro; Schulze, Matthias B.; Bueno-de-Mesquita, Bas; Jose-Sanchez, Maria; Gylling, Bjorn; Zeegers, Maurice P.

doi:10.1007/s00394-022-02805-2

Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies

Journal Article · Mon Feb 07 00:00:00 EST 2022 · European Journal of Nutrition

DOI:https://doi.org/10.1007/s00394-022-02805-2· OSTI ID:1844028

Boot, Iris W. A.; ; Yu, Evan Y. W.; Brinkman, Maree; van den Brandt, Piet; Grant, Eric J.; White, Emily; Weiderpass, Elisabete; Ferrari, Pietro; Schulze, Matthias B.; Bueno-de-Mesquita, Bas; Jose-Sanchez, Maria; Gylling, Bjorn; Zeegers, Maurice P.

Abstract Purpose

Diet may play an essential role in the aetiology of bladder cancer (BC). The B group complex vitamins involve diverse biological functions that could be influential in cancer prevention. The aim of the present study was to investigate the association between various components of the B group vitamin complex and BC risk.

Methods

Dietary data were pooled from four cohort studies. Food item intake was converted to daily intakes of B group vitamins and pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were obtained using Cox-regression models. Dose–response relationships were examined using a nonparametric test for trend.

Results

In total, 2915 BC cases and 530,012 non-cases were included in the analyses. The present study showed an increased BC risk for moderate intake of vitamin B1 (HR _B1 : 1.13, 95% CI: 1.00–1.20). In men, moderate intake of the vitamins B1, B2, energy-related vitamins and high intake of vitamin B1 were associated with an increased BC risk (HR (95% CI): 1.13 (1.02–1.26), 1.14 (1.02–1.26), 1.13 (1.02–1.26; 1.13 (1.02–1.26), respectively). In women, high intake of all vitamins and vitamin combinations, except for the entire complex, showed an inverse association (HR (95% CI): 0.80 (0.67–0.97), 0.83 (0.70–1.00); 0.77 (0.63–0.93), 0.73 (0.61–0.88), 0.82 (0.68–0.99), 0.79 (0.66–0.95), 0.80 (0.66–0.96), 0.74 (0.62–0.89), 0.76 (0.63–0.92), respectively). Dose–response analyses showed an increased BC risk for higher intake of vitamin B1 and B12.

Conclusion

Our findings highlight the importance of future research on the food sources of B group vitamins in the context of the overall and sex-stratified diet.

View Journal Article

Research Organization:: National Academy of Sciences, Washington, DC (United States)

Sponsoring Organization:: National Cancer Institute (NCI); USDOE; USDOE Office of Environment, Health, Safety and Security (AU)

Grant/Contract Number:: HS0000031

OSTI ID:: 1844028

Alternate ID(s):: OSTI ID: 1904815

Journal Information:: European Journal of Nutrition, Journal Name: European Journal of Nutrition Journal Issue: 5 Vol. 61; ISSN 1436-6207

Publisher:: Springer Science + Business MediaCopyright Statement

Country of Publication:: Germany

Language:: English

References (60)

Bladder Cancer: A Review Lenis, Andrew T.; Lec, Patrick M.; Chamie, Karim JAMA, Vol. 324, Issue 19 https://doi.org/10.1001/jama.2020.17598	journal	November 2020
Dietary intake of nutrients involved in one-carbon metabolism and risk of urothelial cell carcinoma: A prospective cohort study: One-carbon metabolism nutrients and UCC risk Dugué, Pierre-Antoine; Brinkman, Maree T.; Hodge, Allison M. International Journal of Cancer, Vol. 143, Issue 2 https://doi.org/10.1002/ijc.31319	journal	March 2018
Economic aspects of bladder cancer: what are the benefits and costs? Sievert, K. D.; Amend, B.; Nagele, U. World Journal of Urology, Vol. 27, Issue 3 https://doi.org/10.1007/s00345-009-0395-z	journal	March 2009
Red and processed meat consumption and risk of bladder cancer: a dose–response meta-analysis of epidemiological studies Crippa, Alessio; Larsson, Susanna C.; Discacciati, Andrea European Journal of Nutrition, Vol. 57, Issue 2 https://doi.org/10.1007/s00394-016-1356-0	journal	December 2016
Optimal nutrition and the ever-changing dietary landscape: a conference report Shao, A.; Drewnowski, A.; Willcox, D. C. European Journal of Nutrition, Vol. 56, Issue S1 https://doi.org/10.1007/s00394-017-1460-9	journal	May 2017
Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study Brinkman, Maree T.; Karagas, Margaret R.; Zens, Michael Scott Cancer Causes & Control, Vol. 21, Issue 4 https://doi.org/10.1007/s10552-009-9490-0	journal	December 2009
Dietary intake of B vitamins and methionine and prostate cancer incidence and mortality Bassett, Julie K.; Severi, Gianluca; Hodge, Allison M. Cancer Causes & Control, Vol. 23, Issue 6 https://doi.org/10.1007/s10552-012-9954-5	journal	April 2012
Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses Al-Zalabani, Abdulmohsen H.; Stewart, Kelly F. J.; Wesselius, Anke European Journal of Epidemiology, Vol. 31, Issue 9 https://doi.org/10.1007/s10654-016-0138-6	journal	March 2016
The association between meat and fish consumption and bladder cancer risk: a pooled analysis of 11 cohort studies Dianatinasab, Mostafa; Wesselius, Anke; de Loeij, Tessa European Journal of Epidemiology, Vol. 36, Issue 8 https://doi.org/10.1007/s10654-021-00762-4	journal	May 2021
A large-scale prospective cohort study on diet and cancer in the Netherlands van den Brandt, Piet A.; Goldbohm, R. Alexandra; Van 'T Veer, Pieter Journal of Clinical Epidemiology, Vol. 43, Issue 3 https://doi.org/10.1016/0895-4356(90)90009-e	journal	January 1990
Dietary Sources of Nutrients among US Adults, 1989 to 1991 Subar, Amy F.; Krebs-Smith, Susan M.; Cook, Annetta Journal of the American Dietetic Association, Vol. 98, Issue 5 https://doi.org/10.1016/S0002-8223(98)00122-9	journal	May 1998
Gender, racial and age differences in bladder cancer incidence and mortality Madeb, Ralph; Messing, Edward M. Urologic Oncology: Seminars and Original Investigations, Vol. 22, Issue 2 https://doi.org/10.1016/S1078-1439(03)00139-X	journal	March 2004
Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism Depeint, Flore; Bruce, W. Robert; Shangari, Nandita Chemico-Biological Interactions, Vol. 163, Issue 1-2 https://doi.org/10.1016/j.cbi.2006.04.014	journal	October 2006
Food, nutrient and heterocyclic amine intake and the risk of bladder cancer García-Closas, Reina; García-Closas, Montserrat; Kogevinas, Manolis European Journal of Cancer, Vol. 43, Issue 11 https://doi.org/10.1016/j.ejca.2007.05.007	journal	July 2007
Epidemiology and Risk Factors of Urothelial Bladder Cancer Burger, Maximilian; Catto, James W. F.; Dalbagni, Guido European Urology, Vol. 63, Issue 2 https://doi.org/10.1016/j.eururo.2012.07.033	journal	February 2013
Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity Fenech, Michael Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 733, Issue 1-2 https://doi.org/10.1016/j.mrfmmm.2011.11.003	journal	May 2012
DNA damage from micronutrient deficiencies is likely to be a major cause of cancer Ames, Bruce N. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 475, Issue 1-2 https://doi.org/10.1016/s0027-5107(01)00070-7	journal	April 2001
Riboflavin (vitamin B ₂ ) and oxidative stress: a review Ashoori, Marziyeh; Saedisomeolia, Ahmad British Journal of Nutrition, Vol. 111, Issue 11 https://doi.org/10.1017/S0007114514000178	journal	March 2014
Arguments for rejecting the sequential Bonferroni in ecological studies Moran, M. D. Oikos, Vol. 100, Issue 2 https://doi.org/10.1034/j.1600-0706.2003.12010.x	journal	February 2003
Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States Wu, J. W.; Cross, A. J.; Baris, D. British Journal of Cancer, Vol. 106, Issue 11 https://doi.org/10.1038/bjc.2012.187	journal	May 2012
The epigenetic progenitor origin of human cancer Feinberg, Andrew P.; Ohlsson, Rolf; Henikoff, Steven Nature Reviews Genetics, Vol. 7, Issue 1 https://doi.org/10.1038/nrg1748	journal	January 2006
Intake of milk and other dairy products and the risk of bladder cancer: a pooled analysis of 13 cohort studies Acham, Merab; Wesselius, Anke; van Osch, Frits H. M. European Journal of Clinical Nutrition, Vol. 74, Issue 1 https://doi.org/10.1038/s41430-019-0453-6	journal	June 2019
Dietary intake of selected B vitamins in relation to risk of major cancers in women Kabat, G. C.; Miller, A. B.; Jain, M. British Journal of Cancer, Vol. 99, Issue 5 https://doi.org/10.1038/sj.bjc.6604540	journal	July 2008
The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study Slimani, N.; Deharveng, G.; Unwin, I. European Journal of Clinical Nutrition, Vol. 61, Issue 9 https://doi.org/10.1038/sj.ejcn.1602679	journal	March 2007
Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study Zeegers, M. P. A.; Goldbohm, R. A.; Brandt, P. A. van den British Journal of Cancer, Vol. 85, Issue 7 https://doi.org/10.1054/bjoc.2001.1968	journal	October 2001
Hepatic Toxicity from Large Doses of Vitamin B ₃ (Nicotinamide) Winter, Stephen L.; Boyer, James L. New England Journal of Medicine, Vol. 289, Issue 22 https://doi.org/10.1056/NEJM197311292892208	journal	November 1973
European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection Riboli, E.; Hunt, Kj; Slimani, N. Public Health Nutrition, Vol. 5, Issue 6b https://doi.org/10.1079/PHN2002394	journal	December 2002
Evaluation of under- and overreporting of energy intake in the 24-hour diet recalls in the European Prospective Investigation into Cancer and Nutrition (EPIC) Ferrari, P.; Slimani, N.; Ciampi, A. Public Health Nutrition, Vol. 5, Issue 6b https://doi.org/10.1079/PHN2002409	journal	December 2002
The role of diet in prostate cancer Kaul, Lalita; Heshmat, Martin Y.; Kovi, Joseph Nutrition and Cancer, Vol. 9, Issue 2-3 https://doi.org/10.1080/01635588709513919	journal	January 1987
Niacin deficiency and cancer in women. Jacobson, E. L. Journal of the American College of Nutrition, Vol. 12, Issue 4 https://doi.org/10.1080/07315724.1993.10718330	journal	August 1993
Riboflavin (vitamin B-2) and health Powers, Hilary J. The American Journal of Clinical Nutrition, Vol. 77, Issue 6 https://doi.org/10.1093/ajcn/77.6.1352	journal	June 2003
Grain and dietary fiber intake and bladder cancer risk: a pooled analysis of prospective cohort studies Yu, Evan Y. W.; Wesselius, Anke; Mehrkanoon, Siamak The American Journal of Clinical Nutrition, Vol. 112, Issue 5 https://doi.org/10.1093/ajcn/nqaa215	journal	August 2020
Reliability and Validity of Self-Report of Vitamin and Mineral Supplement Use in the Vitamins and Lifestyle Study Satia-Abouta, J. American Journal of Epidemiology, Vol. 157, Issue 10 https://doi.org/10.1093/aje/kwg039	journal	May 2003
VITamins And Lifestyle Cohort Study: Study Design and Characteristics of Supplement Users White, E. American Journal of Epidemiology, Vol. 159, Issue 1 https://doi.org/10.1093/aje/kwh010	journal	January 2004
A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP) Ito, Nobuyuki; Hasegawa, Ryohei; Sano, Masashi Carcinogenesis, Vol. 12, Issue 8 https://doi.org/10.1093/carcin/12.8.1503	journal	January 1991
Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis Zingg, J. Carcinogenesis, Vol. 18, Issue 5 https://doi.org/10.1093/carcin/18.5.869	journal	May 1997
Effect of processed and red meat on endogenous nitrosation and DNA damage Joosen, A. M. C. P.; Kuhnle, G. G. C.; Aspinall, S. M. Carcinogenesis, Vol. 30, Issue 8 https://doi.org/10.1093/carcin/bgp130	journal	June 2009
The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition Riboli, E. International Journal of Epidemiology, Vol. 26, Issue 90001 https://doi.org/10.1093/ije/26.suppl_1.s6	journal	February 1997
Quantified relations between exposure to tobacco smoking and bladder cancer risk: a meta-analysis of 89 observational studies van Osch, Frits HM; Jochems, Sylvia HJ; van Schooten, Frederik-Jan International Journal of Epidemiology, Vol. 45, Issue 3 https://doi.org/10.1093/ije/dyw044	journal	April 2016
Gender and Body Size Affect the Response of Erythrocyte Folate to Folic Acid Treatment Winkels, Renate M.; Brouwer, Ingeborg A.; Verhoef, Petra The Journal of Nutrition, Vol. 138, Issue 8 https://doi.org/10.1093/jn/138.8.1456	journal	August 2008
N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids Tricker, A. R. European Journal of Cancer Prevention, Vol. 6, Issue 3 https://doi.org/10.1097/00008469-199706000-00003	journal	January 1997
Body Mass Index, Physical Activity, and Bladder Cancer in a Large Prospective Study Koebnick, Corinna; Michaud, Dominique; Moore, Steven C. Cancer Epidemiology Biomarkers & Prevention, Vol. 17, Issue 5 https://doi.org/10.1158/1055-9965.EPI-08-0026	journal	May 2008
Meat Processing and Colon Carcinogenesis: Cooked, Nitrite-Treated, and Oxidized High-Heme Cured Meat Promotes Mucin-Depleted Foci in Rats Santarelli, Raphaëlle L.; Vendeuvre, Jean-Luc; Naud, Nathalie Cancer Prevention Research, Vol. 3, Issue 7 https://doi.org/10.1158/1940-6207.CAPR-09-0160	journal	June 2010
Linking vitamin B1 with cancer cell metabolism Zastre, Jason A.; Sweet, Rebecca L.; Hanberry, Bradley S. Cancer & Metabolism, Vol. 1, Issue 1 https://doi.org/10.1186/2049-3002-1-16	journal	July 2013
International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics Goossens, Maria E.; Isa, Fatima; Brinkman, Maree Archives of Public Health, Vol. 74, Issue 1 https://doi.org/10.1186/s13690-016-0140-1	journal	July 2016
Case-Control Analysis of Dietary Folate and Risk of Bladder Cancer Schabath, Matthew B.; Spitz, Margaret R.; Lerner, Seth P. Nutrition and Cancer, Vol. 53, Issue 2 https://doi.org/10.1207/s15327914nc5302_3	journal	November 2005
Meat Consumption and Cancer Risk Genkinger, Jeanine M.; Koushik, Anita PLoS Medicine, Vol. 4, Issue 12 https://doi.org/10.1371/journal.pmed.0040345	journal	December 2007
Folate/homocysteine metabolism and lung cancer risk among smokers Stanisławska-Sachadyn, Anna; Borzyszkowska, Joanna; Krzemiński, Michał PLOS ONE, Vol. 14, Issue 4 https://doi.org/10.1371/journal.pone.0214462	journal	April 2019
Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases Ozasa, Kotaro; Shimizu, Yukiko; Suyama, Akihiko Radiation Research, Vol. 177, Issue 3 https://doi.org/10.1667/rr2629.1	journal	March 2012
Epidemiology, aetiology and screening of bladder cancer Cumberbatch, Marcus G. K.; Noon, Aidan P. Translational Andrology and Urology, Vol. 8, Issue 1 https://doi.org/10.21037/tau.2018.09.11	journal	March 2019
Validation of a Food Frequency Questionnaire in the Hiroshima/Nagasaki Life Span Study. Sauvaget, Catherine; Allen, Naomi; Hayashi, Mikiko Journal of Epidemiology, Vol. 12, Issue 5 https://doi.org/10.2188/jea.12.394	journal	January 2002
Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies He, Huadong; Shui, Bing International Journal of Food Sciences and Nutrition, Vol. 65, Issue 3 https://doi.org/10.3109/09637486.2013.866641	journal	December 2013
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Bray, Freddie; Ferlay, Jacques; Soerjomataram, Isabelle CA: A Cancer Journal for Clinicians, Vol. 68, Issue 6 https://doi.org/10.3322/caac.21492	journal	September 2018
Of Meat and Men: Sex Differences in Implicit and Explicit Attitudes Toward Meat Love, Hamish J.; Sulikowski, Danielle Frontiers in Psychology, Vol. 9 https://doi.org/10.3389/fpsyg.2018.00559	journal	April 2018
One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling Corbin, Joshua; Ruiz-Echevarría, Maria International Journal of Molecular Sciences, Vol. 17, Issue 8 https://doi.org/10.3390/ijms17081208	journal	July 2016
B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease Lyon, Peter; Strippoli, Victoria; Fang, Byron Nutrients, Vol. 12, Issue 9 https://doi.org/10.3390/nu12092867	journal	September 2020
Vitamin B6 and colorectal cancer: Current evidence and future directions Zhang, Xue-Hong World Journal of Gastroenterology, Vol. 19, Issue 7 https://doi.org/10.3748/wjg.v19.i7.1005	journal	January 2013
Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study Shen, Jian; Lai, Chao-Qiang; Mattei, Josiemer The American Journal of Clinical Nutrition, Vol. 91, Issue 2 https://doi.org/10.3945/ajcn.2009.28571	journal	December 2009
USDA Food and Nutrient Databases Provide the Infrastructure for Food and Nutrition Research, Policy, and Practice Ahuja, Jaspreet K. C.; Moshfegh, Alanna J.; Holden, Joanne M. The Journal of Nutrition, Vol. 143, Issue 2 https://doi.org/10.3945/jn.112.170043	journal	December 2012
Fruit and Vegetable Intakes Are Associated with Lower Risk of Bladder Cancer among Women in the Multiethnic Cohort Study Park, Song-Yi; Ollberding, Nicholas J.; Woolcott, Christy G. The Journal of Nutrition, Vol. 143, Issue 8 https://doi.org/10.3945/jn.113.174920	journal	June 2013

Similar Records

Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: A pooled analysis of more than a half million participants

Journal Article · Wed May 15 20:00:00 EDT 2024 · Journal of Diabetes · OSTI ID:2350990

Related Subjects

60 APPLIED LIFE SCIENCES
B group vitamins
bladder cancer
nutritional oncology
pooled cohort analysis

Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies

Citation Formats

References (60)

Similar Records

Related Subjects