Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies

Boot, Iris W. A.; Wesselius, Anke; Yu, Evan Y. W.; Brinkman, Maree; van den Brandt, Piet; Grant, Eric J.; White, Emily; Weiderpass, Elisabete; Ferrari, Pietro; Schulze, Matthias B.; Bueno-de-Mesquita, Bas; Jose-Sanchez, Maria; Gylling, Bjorn; Zeegers, Maurice P.

doi:10.1007/s00394-022-02805-2

Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies

Journal Article · Sun Feb 06 23:00:00 EST 2022 · European Journal of Nutrition

DOI:https://doi.org/10.1007/s00394-022-02805-2· OSTI ID:1844028

Boot, Iris W. A.; ; Yu, Evan Y. W.; Brinkman, Maree; van den Brandt, Piet; Grant, Eric J.; White, Emily; Weiderpass, Elisabete; Ferrari, Pietro; Schulze, Matthias B.; Bueno-de-Mesquita, Bas; Jose-Sanchez, Maria; Gylling, Bjorn; Zeegers, Maurice P.

Abstract Purpose

Diet may play an essential role in the aetiology of bladder cancer (BC). The B group complex vitamins involve diverse biological functions that could be influential in cancer prevention. The aim of the present study was to investigate the association between various components of the B group vitamin complex and BC risk.

Methods

Dietary data were pooled from four cohort studies. Food item intake was converted to daily intakes of B group vitamins and pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were obtained using Cox-regression models. Dose–response relationships were examined using a nonparametric test for trend.

Results

In total, 2915 BC cases and 530,012 non-cases were included in the analyses. The present study showed an increased BC risk for moderate intake of vitamin B1 (HR _B1 : 1.13, 95% CI: 1.00–1.20). In men, moderate intake of the vitamins B1, B2, energy-related vitamins and high intake of vitamin B1 were associated with an increased BC risk (HR (95% CI): 1.13 (1.02–1.26), 1.14 (1.02–1.26), 1.13 (1.02–1.26; 1.13 (1.02–1.26), respectively). In women, high intake of all vitamins and vitamin combinations, except for the entire complex, showed an inverse association (HR (95% CI): 0.80 (0.67–0.97), 0.83 (0.70–1.00); 0.77 (0.63–0.93), 0.73 (0.61–0.88), 0.82 (0.68–0.99), 0.79 (0.66–0.95), 0.80 (0.66–0.96), 0.74 (0.62–0.89), 0.76 (0.63–0.92), respectively). Dose–response analyses showed an increased BC risk for higher intake of vitamin B1 and B12.

Conclusion

Our findings highlight the importance of future research on the food sources of B group vitamins in the context of the overall and sex-stratified diet.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: HS0000031

OSTI ID:: 1844028

Journal Information:: European Journal of Nutrition, Journal Name: European Journal of Nutrition Journal Issue: 5 Vol. 61; ISSN 1436-6207

Publisher:: Springer Science + Business MediaCopyright Statement

Country of Publication:: Germany

Language:: English

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