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Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophe

Journal Article · · J. Med. Chem.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1841201
Journal Information:
J. Med. Chem., Journal Name: J. Med. Chem. Journal Issue: (23) Vol. 60
Country of Publication:
United States
Language:
ENGLISH

References (41)

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Immunomodulatory Effect of Combination Therapy with Lovastatin and 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Alleviates Neurodegeneration in Experimental Autoimmune Encephalomyelitis journal September 2006
Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas journal December 2010
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Aminoimidazole Carboxamide Ribonucleotide Ameliorates Experimental Autoimmune Uveitis journal June 2012
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects journal March 2012
Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside journal September 2006
Discovery of 5-Substituted Pyrrolo[2,3- d ]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity journal December 2013
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