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Title: Transgenic silkworms expressing spider silk

Patent ·
OSTI ID:1840348
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Transgenic silkworms stably expressing synthetic spider silk genes or composite silkworm/spider silk genes are disclosed. The exogenous spider silk genes are stably intergrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic spider silk proteins and composite spider silk-silkworm genes and proteins are provided. The expression of exogenous spider silk genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/spider silk fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.

Research Organization:
Utah State Univ., Logan, UT (United States)
Sponsoring Organization:
USDOE; National Science Foundation (NSF)
DOE Contract Number:
EE0006857; IIP1318194
Assignee:
Utah State University (Logan, UT)
Patent Number(s):
11,089,767
Application Number:
15/942,185
OSTI ID:
1840348
Resource Relation:
Patent File Date: 03/30/2018
Country of Publication:
United States
Language:
English

References (26)

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