Transgenic silkworms expressing spider silk

Lewis, Randolph V.; Xia, Lijin; Zhang, Xiaoli; Jones, Justin A.

Transgenic silkworms expressing spider silk

Patent · Tue Aug 17 00:00:00 EDT 2021

OSTI ID:1840348

Lewis, Randolph V.; Xia, Lijin; Zhang, Xiaoli; Jones, Justin A.

Transgenic silkworms stably expressing synthetic spider silk genes or composite silkworm/spider silk genes are disclosed. The exogenous spider silk genes are stably intergrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic spider silk proteins and composite spider silk-silkworm genes and proteins are provided. The expression of exogenous spider silk genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/spider silk fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.

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Research Organization:: Utah State Univ., Logan, UT (United States)

Sponsoring Organization:: USDOE; National Science Foundation (NSF)

DOE Contract Number:: EE0006857

Assignee:: Utah State University (Logan, UT)

Patent Number(s):: 11,089,767

Application Number:: 15/942,185

OSTI ID:: 1840348

Country of Publication:: United States

Language:: English

References (17)

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