Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

The look-elsewhere effect from a unified Bayesian and frequentist perspective

Journal Article · · Journal of Cosmology and Astroparticle Physics
 [1];  [2]
  1. Univ. of California, Berkeley, CA (United States)
  2. Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
When searching over a large parameter space for anomalies such as events, peaks, objects, or particles, there is a large probability that spurious signals with seemingly high signi ficance will be found. This is known as the look-elsewhere effect and is prevalent throughout cosmology, (astro)particle physics, and beyond. To avoid making false claims of detection, one must account for this effect when assigning the statistical significance of an anomaly. This is typically accomplished by considering the trials factor, which is generally computed numerically via potentially expensive simulations. In this paper we develop a continuous generalization of the Bonferroni and Sidak corrections by applying the Laplace approximation to evaluate the Bayes factor, and in turn relating the trials factor to the prior-to-posterior volume ratio. Here, we use this to define a test statistic whose frequentist properties have a simple interpretation in terms of the global p-value, or statistical significance. We apply this method to various physics-based examples and show it to work well for the full range of p-values, i.e. in both the asymptotic and non-asymptotic regimes. We also show that this method naturally accounts for other model complexities such as additional degrees of freedom, generalizing Wilks' theorem. This provides a fast way to quantify statistical significance in light of the look-elsewhere effect, without resorting to expensive simulations.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
National Aeronautics and Space Administration (NASA); National Science Foundation (NSF); USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1838321
Alternate ID(s):
OSTI ID: 23041427
Journal Information:
Journal of Cosmology and Astroparticle Physics, Journal Name: Journal of Cosmology and Astroparticle Physics Journal Issue: 10 Vol. 2020; ISSN 1475-7516
Publisher:
Institute of Physics (IOP)Copyright Statement
Country of Publication:
United States
Language:
English

References (42)

Is the Jeffreys' scale a reliable tool for Bayesian model comparison in cosmology? journal August 2013
Solving the Bible Code Puzzle journal May 1999
Rectangular Confidence Regions for the Means of Multivariate Normal Distributions journal June 1967
Trial factors for the look elsewhere effect in high energy physics text January 2010
Combining power spectrum and bispectrum measurements to detect oscillatory features text January 2014
Do high energy astrophysical neutrinos trace star formation? text January 2015
Kepler data analysis: non-Gaussian noise and Fourier Gaussian process analysis of star variability text January 2019
Normalizing Constant Estimation with Gaussianized Bridge Sampling text January 2019
The Jeffreys–Lindley paradox and discovery criteria in high energy physics journal July 2014
Practical Guidelines for Multiplicity Adjustment in Clinical Trials journal December 2000
Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC journal September 2012
Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC journal September 2012
Efficiency and power in genetic association studies journal October 2005
Planck 2013 results. XXIV. Constraints on primordial non-Gaussianity journal October 2014
Planck 2013 results. XV. CMB power spectra and likelihood journal October 2014
Planck 2015 results : XI. CMB power spectra, likelihoods, and robustness of parameters journal September 2016
Statistical significance for genomewide studies journal July 2003
Rectangular Confidence Regions for the Means of Multivariate Normal Distributions journal June 1967
Efficient Computation of Cosmic Microwave Background Anisotropies in Closed Friedmann‐Robertson‐Walker Models journal August 2000
FIVE-YEAR WILKINSON MICROWAVE ANISOTROPY PROBE OBSERVATIONS: COSMOLOGICAL INTERPRETATION journal February 2009
Non-gaussian features of primordial fluctuations in single field inflationary models journal May 2003
Limits on non-Gaussianities from WMAP data journal May 2006
Do high energy astrophysical neutrinos trace star formation? journal December 2015
Search for features in the spectrum of primordial perturbations using Planck and other datasets journal December 2015
Search for gamma-ray lines towards galaxy clusters with the Fermi-LAT journal February 2016
A precision search for WIMPs with charged cosmic rays journal January 2018
Bayesian and frequentist approaches to resonance searches journal October 2019
A Statistical Paradox journal January 1957
Hypothesis testing when a nuisance parameter is present only under the alternative journal January 1987
A search for a keV signature of radiatively decaying dark matter with Suzaku XIS observations of the X-ray diffuse background journal September 2015
Cosmological parameters from CMB and other data: A Monte Carlo approach journal November 2002
Combining power spectrum and bispectrum measurements to detect oscillatory features journal January 2015
Polyspectra searches for sharp oscillatory features in cosmic microwave sky data journal June 2015
GW150914: First results from the search for binary black hole coalescence with Advanced LIGO journal June 2016
Analysis framework for the prompt discovery of compact binary mergers in gravitational-wave data journal February 2017
Extracting Primordial Non-Gaussianity without Cosmic Variance journal January 2009
Observation of High-Energy Astrophysical Neutrinos in Three Years of IceCube Data journal September 2014
Trial factors for the look elsewhere effect in high energy physics journal October 2010
Asymptotic formulae for likelihood-based tests of new physics journal February 2011
Multiple Hypothesis Testing journal January 1995
The Large-Sample Distribution of the Likelihood Ratio for Testing Composite Hypotheses journal March 1938
Hypothesis Testing When a Nuisance Parameter is Present Only Under the Alternative journal August 1977

Similar Records

Statistical Significance Testing for Mixed Priors: A Combined Bayesian and Frequentist Analysis
Journal Article · Tue Sep 20 20:00:00 EDT 2022 · Entropy · OSTI ID:1994364

Fast estimation of the look-elsewhere effect using Gaussian random fields
Journal Article · Sun Nov 12 19:00:00 EST 2023 · European Physical Journal. C, Particles and Fields (Online) · OSTI ID:2205524

Unaccounted-for look-elsewhere effect in k-fold cross adaptive anomaly searches
Conference · Mon Jul 07 00:00:00 EDT 2025 · No journal information · OSTI ID:2571312