Familial migraine: Exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p

Journal Article · Sat Oct 01 04:00:00 EDT 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1563· OSTI ID:183708

Hovatta, I; Peltonen, L ^[1]; Kallela, M; Faerkkilae, M ^[2]

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1. National Public Health Institute, Helsinki (Finland)
2. Helsinki Univ. Central Hospital (Finland)

Genetic isolates are highly useful in analyses of the molecular background of complex diseases since the enrichment of a limited number of predisposing genes can be predicted in representative families or in specific geographical regions. It has been suggested that the pathophysiology and etiology of familial hemiplegic migraine (FHM) and typical migraine with aura are most probably the same. Recent assignment of FHM locus to chromosome 19p in two French families makes it now possible to test this hypothesis. We report here linkage data on four families with multiple cases of migraine disorder originating from the genetically isolated population of Finland. We were interested to discover whether the migraine in these families would also show linkage to the markers on 19p. We could exclude a region of 50 cM, flanking the reported FHM locus, as a site of migraine locus in our four families. It seems evident that locus heterogeneity exists between different diagnostic classes of migraine spectrum of diseases and also between different ethnic groups. 10 refs., 2 figs., 1 tab.

• OSTI ID: 183708
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 23; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
DIAGNOSIS
ETIOLOGY
FINLAND
GENES
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HUMAN CHROMOSOME 19
MINORITY GROUPS
NERVOUS SYSTEM DISEASES
PATIENTS
STATISTICS