Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Usi

Gavai, Ashvinikumar V.; Norris, Derek; Delucca, George; Tortolani, David; Tokarski, John S.; Dodd, Dharmpal; O?Malley, Daniel; Zhao, Yufen; Quesnelle, Claude; Gill, Patrice; Vaccaro, Wayne; Huynh, Tram; Ahuja, Vijay; Han, Wen-Ching; Mussari, Christopher; Harikrishnan, Lalgudi; Kamau, Muthoni; Poss, Michael; Sheriff, Steven; Yan, Chunhong; Marsilio, Frank; Menard, Krista; Wen, Mei-Li; Rampulla, Richard; Wu, Dauh-Rurng; Li, Jianqing; Zhang, Huiping; Li, Peng; Sun, Dawn; Yip, Henry; Traeger, Sarah C.; Zhang, Yingru; Mathur, Arvind; Zhang, Haiying; Huang, Christine; Yang, Zheng; Ranasinghe, Asoka; Everlof, Gerry; Raghavan, Nirmala; Tye, Ching Kim; Wee, Susan; Hunt, John T.; Vite, Gregory; Westhouse, Richard; Lee, Francis Y.

doi:10.1021/acs.jmedchem.1c00625

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Usi

Journal Article · 01 September 2021 · J. Med. Chem.

DOI:https://doi.org/10.1021/acs.jmedchem.1c00625· OSTI ID:1834907

Gavai, Ashvinikumar V.; Norris, Derek; Delucca, George; Tortolani, David; Tokarski, John S.; Dodd, Dharmpal; O?Malley, Daniel; Zhao, Yufen; Quesnelle, Claude; Gill, Patrice; Vaccaro, Wayne; Huynh, Tram; Ahuja, Vijay; Han, Wen-Ching; Mussari, Christopher; Harikrishnan, Lalgudi; Kamau, Muthoni; Poss, Michael; Sheriff, Steven; Yan, Chunhong more »

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1834907

Journal Information:: J. Med. Chem., Vol. 64, Issue (19)

Country of Publication:: United States

Language:: ENGLISH

References (31)

Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches No authors listed Oncogene https://doi.org/10.1038/onc.2016.485		January 2017
Bromodomain: an acetyl-lysine binding domain No authors listed FEBS Letters https://doi.org/10.1016/S0014-5793(01)03309-9		January 2002
The bromodomain interaction module No authors listed FEBS Letters https://doi.org/10.1016/j.febslet.2012.04.045		May 2012
Functions of Site-Specific Histone Acetylation and Deacetylation No authors listed Annual Review of Biochemistry https://doi.org/10.1146/annurev.biochem.76.052705.162114		June 2007
Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions No authors listed Journal of Medicinal Chemistry https://doi.org/10.1021/jm300915b		September 2012
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers No authors listed Cell https://doi.org/10.1016/j.cell.2013.03.036		April 2013
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc No authors listed Cell https://doi.org/10.1016/j.cell.2011.08.017		September 2011
Targeting MYC dependence in cancer by inhibiting BET bromodomains No authors listed Proceedings of the National Academy of Sciences https://doi.org/10.1073/pnas.1108190108		September 2011
Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression No authors listed Molecular Cancer Therapeutics https://doi.org/10.1158/1535-7163.MCT-15-0037		August 2015
Selective inhibition of BET bromodomains No authors listed Nature https://doi.org/10.1038/nature09504		September 2010
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia No authors listed Nature https://doi.org/10.1038/nature10334		August 2011
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia No authors listed Nature https://doi.org/10.1038/nature10509		October 2011
Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer No authors listed Clinical Cancer Research https://doi.org/10.1158/1078-0432.CCR-12-3904		September 2013
Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins No authors listed Proceedings of the National Academy of Sciences https://doi.org/10.1073/pnas.1216363109		November 2012
Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma No authors listed Clinical Cancer Research https://doi.org/10.1158/1078-0432.CCR-12-3066		February 2013
Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. No authors listed Oncotarget https://doi.org/10.18632/oncotarget.1572		November 2013
Suppression of inflammation by a synthetic histone mimic No authors listed Nature https://doi.org/10.1038/nature09589		November 2010
BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells No authors listed Oncotarget https://doi.org/10.18632/oncotarget.4131		May 2015
Achieving clinical success with BET inhibitors as anti-cancer agents No authors listed British Journal of Cancer https://doi.org/10.1038/s41416-021-01321-0		March 2021
BET inhibitor resistance emerges from leukaemia stem cells No authors listed Nature https://doi.org/10.1038/nature14888		September 2015
Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds No authors listed Journal of Medicinal Chemistry https://doi.org/10.1021/jm201136z		April 2012
Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancer No authors listed Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL, Experimental and Molecular Therapeutics https://doi.org/10.1158/1538-7445.AM2018-5789		July 2018
Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters No authors listed Journal of Medicinal Chemistry https://doi.org/10.1021/jm0309349		November 2003
Beamline 08ID-1, the prime beamline of the Canadian Macromolecular Crystallography Facility No authors listed Journal of Synchrotron Radiation https://doi.org/10.1107/S0909049511019431		June 2011
Integration, scaling, space-group assignment and post-refinement No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444909047374		January 2010
Scaling and assessment of data quality No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444905036693		December 2005
[20] Processing of X-ray diffraction data collected in oscillation mode No authors listed Macromolecular Crystallography Part A https://doi.org/10.1016/S0076-6879(97)76066-X		January 1997
Phaser crystallographic software No authors listed Journal of Applied Crystallography https://doi.org/10.1107/S0021889807021206		July 2007
Refinement of severely incomplete structures with maximum likelihood in BUSTER–TNT No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444904016427		November 2004
Features and development of Coot No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444910007493		March 2010
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments No authors listed Journal of Computer-Aided Molecular Design https://doi.org/10.1007/s10822-013-9644-8		March 2013

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