Metabolic engineering of non-pathogenic microorganisms for 2,3-butanediol production

Lee, Jae Won; Lee, Ye-Gi; Jin, Yong-Su; Rao, Christopher V.

doi:10.1007/s00253-021-11436-2

Metabolic engineering of non-pathogenic microorganisms for 2,3-butanediol production

Journal Article · Wed Jul 21 00:00:00 EDT 2021 · Applied Microbiology and Biotechnology

DOI:https://doi.org/10.1007/s00253-021-11436-2· OSTI ID:1834453

Lee, Jae Won ^[1]; Lee, Ye-Gi ^[2]; Jin, Yong-Su ^[2]; ^[2]

Univ. of Illinois at Urbana-Champaign, IL (United States); University of Illinois
Univ. of Illinois at Urbana-Champaign, IL (United States)

2,3-Butanediol (2,3-BDO) is a promising commodity chemical with various industrial applications. While petroleum-based chemical processes currently dominate the industrial production of 2,3-BDO, fermentation-based production of 2,3-BDO pro- vides an attractive alternative to chemical-based processes with regards to economic and environmental sustainability. The achievement of high 2,3-BDO titer, yield, and productivity in microbial fermentation is a prerequisite for the production of 2,3-BDO at large scales. Also, enantiopure production of 2,3-BDO production is desirable because 2,3-BDO stereoisomers have unique physicochemical properties. Pursuant to these goals, many metabolic engineering strategies to improve 2,3-BDO pro- duction from inexpensive sugars by Klebsiella oxytoca, Bacillus species, and Saccharomyces cerevisiae have been developed. Furthermore, this review summarizes the recent advances in metabolic engineering of non-pathogenic microorganisms to enable efficient and enantiopure production of 2,3-BDO.

View Accepted Manuscript (DOE)

Research Organization:: Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0018420

OSTI ID:: 1834453

Journal Information:: Applied Microbiology and Biotechnology, Journal Name: Applied Microbiology and Biotechnology Journal Issue: 14-15 Vol. 105; ISSN 0175-7598

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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2
3-BDO stereoisomers
2
3-Butanediol (2
3-BDO)
59 BASIC BIOLOGICAL SCIENCES
Bacillus species
Klebsiella oxytoca
Saccharomyces cerevisiae

Metabolic engineering of non-pathogenic microorganisms for 2,3-butanediol production

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