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Title: Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltran

Journal Article · · ACS Med. Chem. Lett.
; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1831206
Journal Information:
ACS Med. Chem. Lett., Vol. 12, Issue (3)
Country of Publication:
United States
Language:
ENGLISH

References (19)

N-terminal α-methylation of RCC1 is necessary for stable chromatin association and normal mitosis journal April 2007
α-N-Methylation of Damaged DNA-binding Protein 2 (DDB2) and Its Function in Nucleotide Excision Repair journal June 2014
Chemical Biology of Protein N‐Terminal Methyltransferases journal February 2019
Primary structure of protein L33 from the large subunit of the Escherichia coli ribosome journal September 1976
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere journal March 2017
Identification and Functional Characterizations of N-Terminal α- N -Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3 journal April 2015
Identification of Novel α-N-Methylation of CENP-B That Regulates Its Binding to the Centromeric DNA journal August 2013
NRMT is an α-N-methyltransferase that methylates RCC1 and retinoblastoma protein journal August 2010
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1 journal November 2013
Structural basis for substrate recognition by the human N-terminal methyltransferase 1 journal November 2015
An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2 journal November 2018
Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis journal March 2015
NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging journal March 2015
Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1 journal February 2019
Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues journal July 2020
Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors journal January 2015
Facile synthesis of SAM–peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1 journal January 2016
Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies journal July 2020
Kinetic Mechanism of Protein N-terminal Methyltransferase 1 journal May 2015

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