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The novel Mechanical Ventilator Milano for the COVID-19 pandemic

Journal Article · · Physics of Fluids
DOI:https://doi.org/10.1063/5.0044445· OSTI ID:1829795
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  1. Nuclear Instruments S.R.L., Como 22045, Italy
  2. Elemaster Group S.p.A., Lomagna (LC) 23871, Italy
  3. Department of Physics, University of Houston, Houston, Texas 77204, USA
  4. Istituto per la Scienza e Tecnologia dei Plasmi, ISTP-CNR, Milano 20125, Italy
  5. TRIUMF, Vancouver, British Columbia V6T 2A3, Canada
  6. INFN Sezione di Pisa, Pisa 56127, Italy
  7. APC, Université de Paris, CNRS, Astroparticule et Cosmologie, F-75013 Paris, France
  8. SNOLAB, Lively, Ontario P3Y 1N2, Canada
  9. Gran Sasso Science Institute, L'Aquila 67100, Italy
  10. Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato, CNR STIIMA, Milano 20133, Italy
  11. INFN Sezione di Pisa, Pisa 56127, Italy; Dipartimento di Fisica, Università di Pisa, Pisa 56124, Italy
  12. LSC, Laboratorio Subterráneo de Canfranc, Canfranc-Estación 22880, Spain
  13. JMP Solutions, London, Ontario N6N 1E2, Canada
  14. Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato, CNR STIIMA, Milano 20133, Italy; Dipartimento di Ingegneria Meccanica e Industriale, Università degli Studi di Brescia, Brescia 25123, Italy
  15. Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Pisa 56124, Italy
  16. Camozzi Group S.p.A., Brescia BS 25126, Italy
  17. Dipartimento di Ingegneria Gestionale, dell'Informazione e della Produzione, Università di Bergamo, Bergamo, 24129, Italy
  18. INFN Sezione di Cagliari, Cagliari 09042, Italy
  19. Canadian Nuclear Laboratories, Chalk River K0J 1J0, Canada
  20. Fermi National Accelerator Laboratory, Batavia, Illinois 60510, USA
  21. INFN-CNAF, Bologna 40127, Italy
  22. INFN Sezione di Napoli, Napoli 80126, Italy
  23. CIEMAT, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain
  24. Dipartimento di Fisica, Università di Milano-Bicocca, Milano 20126, Italy
  25. Fermi National Accelerator Laboratory, Batavia, Illinois 60510, USA; Northwestern University, 633 Clark St, Evanston, Illinois 60208, USA
  26. Dipartimento di Scienze Economiche ed Aziendali, Università degli Studi di Cagliari, Cagliari 09042, Italy
  27. National Center for Innovative Technologies in Public Health, ISS (Italy National Institute of Health), Roma 00161, Italy
  28. Laboratoire Leprince Ringuet, École Polytechnique, Palaiseau, Cedex 91128, France
  29. Dipartimento di Fisica, Università degli Studi di Cagliari, Cagliari 09042, Italy
  30. Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
  31. VEXOS, Markham, Ontario L3R 9X6, Canada
  32. Gran Sasso Science Institute, L'Aquila 67100, Italy; INFN Sezione di Roma, Roma 00185, Italy
  33. INFN Sezione di Napoli, Napoli 80126, Italy; Dipartimento di Fisica, Università degli Studi Federico II di Napoli, Napoli 80126, Italy
  34. Azienda Ospedaliera San Gerardo, Monza 20900, Italy; Dipartimento di Medicina e Chirurgia, Università di Milano-Bicocca, Milano 20126, Italy
  35. Exida Canada Ltd., Mississauga, Ontario L5G 2B6, Canada
  36. INFN Laboratori Nazionali del Gran Sasso, Assergi (AQ) 67100, Italy
  37. Gran Sasso Science Institute, L'Aquila 67100, Italy; INFN Laboratori Nazionali del Gran Sasso, Assergi (AQ) 67100, Italy; Physics Department, Princeton University, Princeton, New Jersey 08544, USA
  38. Policlinico San Pietro, Ponte San Pietro 24036, Italy
  39. Department of Physics, Carleton University, Ottawa, Ontario K1S 5B6, Canada; Arthur B. McDonald Canadian Astroparticle Research Institute, Kingston, Ontario K7L 3N6, Canada
  40. Department of Physics and Astronomy, University of Nebraska-Lincoln, Lincoln, Nebraska 68508, USA
  41. Max-Planck-Institut für Physik (Werner-Heisenberg-Institut), 80805 München, Germany
  42. Physics Department, Princeton University, Princeton, New Jersey 08544, USA
  43. INFN Sezione di Roma, Roma 00185, Italy
  44. TRIUMF, Vancouver, British Columbia V6T 2A3, Canada; Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
  45. ARAID, Fundación Agencia Aragonesa para la Investigación y el Desarrollo, Gobierno de Aragón, Zaragoza 50018, Spain; Departamento de Medicina, Universidad de Zaragoza, Zaragoza 50009, Spain
  46. Department of APT, Faculty of Medicine, University of British Columbia, Vancouver V5Z 1M9, Canada
  47. CAPA (Centro de Astropartículas y Física de Altas Energías), Universidad de Zaragoza, Zaragoza 50009, Spain
  48. Dipartimento di Meccanica, Politecnico di Milano, Milano 20156, Italy
  49. ARAID, Fundación Agencia Aragonesa para la Investigación y el Desarrollo, Gobierno de Aragón, Zaragoza 50018, Spain; CAPA (Centro de Astropartículas y Física de Altas Energías), Universidad de Zaragoza, Zaragoza 50009, Spain
  50. Department of Respiratory and Anaesthesia Technology, Vanier College, Montréal, Quebec H4L 3X9, Canada
  51. Arthur B. McDonald Canadian Astroparticle Research Institute, Kingston, Ontario K7L 3N6, Canada; Department of Physics, Engineering Physics and Astronomy, Queen's University, Kingston, Ontario K7L 3N6, Canada
  52. Dipartimento di Pediatria, Sapienza Università di Roma, Roma 00185, Italy
  53. School of Civil and Mechanical Engineering, Curtin University, Perth (Washington), Australia
  54. INFN Genova, Genova 16146, Italy; Dipartimento di Fisica, Università degli Studi di Genova, Genova 16146, Italy
  55. Azienda Ospedaliera San Gerardo, Monza 20900, Italy
  56. Sergio Installazioni snc, Treviglio (BG) 24047, Italy
  57. INFN Sezione di Milano, Milano 20133, Italy
  58. Department of Computer Science and Engineering, Chalmers—University of Gothenburg, Gothenburg SE-412 96, Sweden; DISIM, Università de L'Aquila, L'Aquila 67100, Italy
  59. LSC, Laboratorio Subterráneo de Canfranc, Canfranc-Estación 22880, Spain; CIEMAT, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain
  60. Amherst Center for Fundamental Interactions and Physics Department, University of Massachusetts, Amherst, Massachusetts 01003, USA
  61. Equilibar L.L.C., Fletcher, North Carolina 28732, USA
  62. Dipartimento di Informatica, Universitá degli Studi di Milano, Milano 20122, Italy
  63. APC, Université de Paris, CNRS, Astroparticule et Cosmologie, F-75013 Paris, France; LPNHE, CNRS/IN2P3, Sorbonne Université, Université Paris Diderot, Paris 75252, France
  64. Istituto di Fisiologia Clinica del CNR, IFC-CNR, Pisa 56124, Italy
  65. INFN Sezione di Bologna, Bologna 40126, Italy
  66. SUBATECH, IMT Atlantique, Université de Nantes, CNRS-IN2P3, Nantes 44300, France
  67. St. Michael's Hospital, Unity Health Toronto, Ontario M5B 1W8, Canada
  68. 12th Man Technologies, Garden Grove, California 92841, USA
  69. MINES ParisTech, PSL University, CTP-Centre of Thermodynamics of Processes, 77300 Fontainebleau, France
  70. AstroCeNT, Nicolaus Copernicus Astronomical Center, Polish Academy of Sciences, Warsaw 00-614, Poland
  71. Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
  72. Arthur B. McDonald Canadian Astroparticle Research Institute, Kingston, Ontario K7L 3N6, Canada
  73. Department of Physics, University of Oxford, The Denys Wilkinson Building, Keble Road, Oxford OX1 3RH, United Kingdom
  74. Dipartimento di Ingegneria Meccanica e Industriale, Università degli Studi di Brescia, Brescia 25123, Italy
  75. Physics and Astronomy Department, University of California, Los Angeles, California 90095, USA
+ Show Author Affiliations

This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Furthermore, following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world

Research Organization:
Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC), High Energy Physics (HEP)
Contributing Organization:
MVM Collaboration
Grant/Contract Number:
AC02-07CH11359
OSTI ID:
1829795
Report Number(s):
FERMILAB-PUB--21-601-ND-PPD-QIS-SCD; oai:inspirehep.net:1858289
Journal Information:
Physics of Fluids, Journal Name: Physics of Fluids Journal Issue: 3 Vol. 33; ISSN 1070-6631
Publisher:
American Institute of Physics (AIP)Copyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
Biomedical equipment
Computer software
Diseases and conditions
Electronic circuits
Graphical user interface
Mechanical ventilation
Pneumatic valve springs
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