Pressure-Sensitive Adhesive Combined with Paper Spray Mass Spectrometry for Low-Cost Collection and Analysis of Drug Residues

Nguyen, Chau Bao; Wichert, William A.; Carmany, Daniel O.; McBride, Ethan M.; Mach, Phillip M.; Dhummakupt, Elizabeth S.; Glaros, Trevor; Manicke, Nicholas E.

doi:10.1021/acs.analchem.1c02050

Pressure-Sensitive Adhesive Combined with Paper Spray Mass Spectrometry for Low-Cost Collection and Analysis of Drug Residues

Journal Article · Tue Sep 28 00:00:00 EDT 2021 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.1c02050· OSTI ID:1827590

Nguyen, Chau Bao ^[1]; Wichert, William A. ^[1]; Carmany, Daniel O. ^[2]; McBride, Ethan M. ^[3]; ^[4]; ^[2]; ^[2]; ^[1]

Indiana Univ.-Purdue Univ. Indianapolis (IUPUI), Indianapolis, IN (United States)
DEVCOM Chemical Biological Center, Aberdeen Proving Grounds, MD (United States)
INFICON, Inc., Syracuse, NY (United States)
DEVCOM Chemical Biological Center, Aberdeen Proving Grounds, MD (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Illicit drug use causes over half a million deaths worldwide every year. Drugs of abuse are commonly smuggled through customs and border checkpoints and, increasingly, through parcel delivery services. Improved methods for detection of trace drug residues from surfaces are needed. Such methods should be robust, fieldable, sensitive, and capable of detecting a wide range of drugs. In this work, commercially produced paper with a pressure-sensitive adhesive coating was utilized for the collection and analysis of trace drug residues by paper spray mass spectrometry (MS). This modified substrate was used to combine sample collection of drug residues from surfaces with rapid detection using a single paper spray ticket. The all-in-one ticket was used to probe different surfaces commonly encountered in forensic work including clothing, cardboard, glass, concrete, asphalt, and aluminum. A total of 10 drugs (acetyl fentanyl, fentanyl, clonazolam, cocaine, heroin, ketamine, methamphetamine, methylone, U-47700, and XLR-11) were evaluated and found to be detectable in the picogram range using a benchtop mass spectrometer and in the low nanogram range using a portable ion trap MS. Finally, the novel approach demonstrates a simple yet effective sampling strategy, allowing for rapid identification from difficult surfaces via paper spray mass spectrometry.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: U.S. Army; USDOE

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1827590

Report Number(s):: LA-UR--21-25443

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 40 Vol. 93; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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