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Immunocompromised Cas9 transgenic mice for rapid in vivo assessment of host factors involved in highly pathogenic virus infection

Journal Article · · Molecular Therapy. Methods & Clinical Development

Not Available

Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC52-07NA27344; NA0003525
OSTI ID:
1823296
Alternate ID(s):
OSTI ID: 1834134
OSTI ID: 1840140
Journal Information:
Molecular Therapy. Methods & Clinical Development, Journal Name: Molecular Therapy. Methods & Clinical Development Journal Issue: C Vol. 23; ISSN 2329-0501
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (32)

Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect journal January 2021
Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery journal September 2020
Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1 journal January 2016
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing journal February 2018
Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis journal March 2016
Protection against lethal Rift Valley fever virus (RVFV) infection in transgenic IFNAR−/− mice induced by different DNA vaccination regimens journal April 2010
The pathogenesis of Rift Valley fever virus in the mouse model journal November 2010
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1 journal August 2011
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing journal November 2017
Host-directed therapies for bacterial and viral infections journal September 2017
A CRISPR toolbox to study virus–host interactions journal April 2017
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus journal January 2019
Wwp2 maintains cartilage homeostasis through regulation of Adamts5 journal June 2019
Characterization of a filovirus (Měnglà virus) from Rousettus bats in China journal January 2019
CRIS.py: A Versatile and High-throughput Analysis Program for CRISPR-based Genome Editing journal March 2019
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2 journal August 2020
Delivering CRISPR: a review of the challenges and approaches journal January 2018
A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever journal September 1998
Assessment of a Vesicular Stomatitis Virus–Based Vaccine by Use of the Mouse Model of Ebola Virus Hemorrhagic Fever journal November 2007
Stat1 -Deficient Mice Are Not an Appropriate Model for Efficacy Testing of Recombinant Vesicular Stomatitis Virus–Based Filovirus Vaccines journal May 2015
CRISPR-Cas guides the future of genetic engineering journal August 2018
Systematic discovery of natural CRISPR-Cas12a inhibitors journal September 2018
Rift Valley Fever Virus Strain MP-12 Enters Mammalian Host Cells via Caveola-Mediated Endocytosis journal September 2012
Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo journal May 2015
Virus-Host Interactions: From Unbiased Genetic Screens to Function journal November 2015
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing journal August 2014
Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation journal February 2013
Ebola Virus Entry: A Curious and Complex Series of Events journal April 2015
Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor journal January 2019
Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir journal February 2019
Mouse Models for Filovirus Infections journal September 2012
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats journal December 2015

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