Isolation of a presumed mucoprotein fraction from rat intestine
The mucoproteins of intestinal mucosa are of interest to radiation biochemistry for a variety of reasons: (a) the known sensitivity of intestine to x-radiation; (b) post-irradiation bacteremia characterized by the presence in the blood of intestinal microorganisms, which may indicate degradation of such a `ground substance` as mucoproteins are considered to be; (c) post-irradiation desquamation of intestinal epithelium; and (d) post-irradiation increase in serum polysaccharide, which may arise from degradation of x-ray sensitive glycoprotein (mucoprotein). Considerable effort has therefore been put into an attempt to isolate an intestinal mucoprotein on which to test the effects of irradiation. A protein fraction has now been isolated which, on the basis only of its method of preparation, is suggested may be a mucoprotein. The material has not yet been fully characterized, nor is its degree of homogeneity known. 10 refs., 1 tab.
- Research Organization:
- Chicago Univ., IL (United States)
- OSTI ID:
- 182184
- Report Number(s):
- COO--22; ON: TI95013638
- Country of Publication:
- United States
- Language:
- English
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