Preparation of pH ‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

Li, Yuhang; Wang, Cong; Luan, Yunhao; Liu, Wanyi; Chen, Tiantian; Liu, Pengtao; Liu, Zhong

doi:10.1002/app.51647

Preparation of pH ‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

Journal Article · Wed Sep 15 00:00:00 EDT 2021 · Journal of Applied Polymer Science

DOI:https://doi.org/10.1002/app.51647· OSTI ID:1820232

Li, Yuhang ^[1]; Wang, Cong ^[1]; Luan, Yunhao ^[1]; Liu, Wanyi ^[1]; Chen, Tiantian ^[1]; ^[1]; Liu, Zhong ^[1]

Tianjin Key Laboratory of Pulp and Paper Tianjin University of Science and Technology Tianjin China

Abstract

In this work, hydrogels composed of cellulose nanofibril (CNF) and sodium alginate (SA) were prepared as a pH‐responsive release system by controlling the amount of CNF and SA. Scanning electron microscopy, thermogravimetric analysis, and swelling rate methods were used to characterize. The results showed that when the mass ratio of CNF to SA was 2:1, CNF/SA hydrogels with better morphology were obtained. Due to the deprotonation or protonation of calcium alginate, as the pH changing from 1.5 to 11.0, the swelling ratio increased from 7 times to 19 times compared with its dry weight. The drug release behaviors of the CNF/SA hydrogels using ibuprofen (IBU) as a model drug were investigated in vitro. The release of IBU was faster in alkaline conditions and slower in acidic conditions. The drug release mechanism under pH stimulation could be interpreted by the Fickian diffusion and erosion effect based on Korsmeyer‐Peppas model.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

OSTI ID:: 1820232

Journal Information:: Journal of Applied Polymer Science, Journal Name: Journal of Applied Polymer Science Journal Issue: 7 Vol. 139; ISSN 0021-8995

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

References (39)

Surfactant mediated clofazimine release from nanocellulose-hydrogels Piotto, Chiara; Bettotti, Paolo Cellulose, Vol. 26, Issue 7 https://doi.org/10.1007/s10570-019-02407-y	journal	April 2019
Natural polymers for gene delivery and tissue engineering☆ Dang, J.; Leong, K. Advanced Drug Delivery Reviews, Vol. 58, Issue 4 https://doi.org/10.1016/j.addr.2006.03.001	journal	July 2006
A sulfur dioxide polymer prodrug showing combined effect with doxorubicin in combating subcutaneous and metastatic melanoma An, Lin; Zhang, Peng; Shen, Wei Bioactive Materials, Vol. 6, Issue 5 https://doi.org/10.1016/j.bioactmat.2020.10.027	journal	May 2021
Cylindrical polymer brushes-anisotropic unimolecular micelle drug delivery system for enhancing the effectiveness of chemotherapy Bai, Shuang; Jia, Die; Ma, Xianbin Bioactive Materials, Vol. 6, Issue 9 https://doi.org/10.1016/j.bioactmat.2021.02.011	journal	September 2021
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis Han, Ying; Yang, Jielai; Zhao, Weiwei Bioactive Materials, Vol. 6, Issue 10 https://doi.org/10.1016/j.bioactmat.2021.03.022	journal	October 2021
pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine Işıklan, Nuran; İnal, Murat; Kurşun, Fatma Carbohydrate Polymers, Vol. 84, Issue 3 https://doi.org/10.1016/j.carbpol.2010.12.054	journal	March 2011
Facile fabrication of redox/pH dual stimuli responsive cellulose hydrogel Liu, Hongchen; Rong, Liduo; Wang, Bijia Carbohydrate Polymers, Vol. 176 https://doi.org/10.1016/j.carbpol.2017.08.085	journal	November 2017
Semi-IPN superabsorbent nanocomposite based on sodium alginate and montmorillonite: Reaction parameters and swelling characteristics Olad, Ali; Pourkhiyabi, Mahyar; Gharekhani, Hamed Carbohydrate Polymers, Vol. 190 https://doi.org/10.1016/j.carbpol.2018.02.088	journal	June 2018
Starch-based semi-IPN hydrogel nanocomposite integrated with clinoptilolite: Preparation and swelling kinetic study Olad, Ali; Doustdar, Fatemeh; Gharekhani, Hamed Carbohydrate Polymers, Vol. 200 https://doi.org/10.1016/j.carbpol.2018.08.014	journal	November 2018
Nanoformulations of quercetin and cellulose nanofibers as healthcare supplements with sustained antioxidant activity Li, Xiaohe; Liu, Yongzhuang; Yu, Yanyan Carbohydrate Polymers, Vol. 207 https://doi.org/10.1016/j.carbpol.2018.11.084	journal	March 2019
Anisotropic nanocellulose gel–membranes for drug delivery: Tailoring structure and interface by sequential periodate–chlorite oxidation Plappert, Sven F.; Liebner, Falk W.; Konnerth, Johannes Carbohydrate Polymers, Vol. 226 https://doi.org/10.1016/j.carbpol.2019.115306	journal	December 2019
Chitosan-cellulose hydrogel conjugated with L-histidine and zinc oxide nanoparticles for sustained drug delivery: Kinetics and in-vitro biological studies George, Dhanya; Maheswari, P. Uma; Begum, K. M. Meera Sheriffa Carbohydrate Polymers, Vol. 236 https://doi.org/10.1016/j.carbpol.2020.116101	journal	May 2020
Preparation of Curdlan sulphate - Chitosan nanoparticles as a drug carrier to target Mycobacterium smegmatis infected macrophages Ravindran, Radhika; Mitra, Kartik; Arumugam, Senthil Kumar Carbohydrate Polymers, Vol. 258 https://doi.org/10.1016/j.carbpol.2021.117686	journal	April 2021
High-strength and pH-responsive self-healing polyvinyl alcohol/poly 6-acrylamidohexanoic acid hydrogel based on dual physically cross-linked network Guo, Peipei; Liang, Jiaqi; Li, Yangyang Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 571 https://doi.org/10.1016/j.colsurfa.2019.03.027	journal	June 2019
Fabrication and characterization of a starch-based superabsorbent hydrogel composite reinforced with cellulose nanocrystals from potato peel waste Olad, Ali; Doustdar, Fatemeh; Gharekhani, Hamed Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 601 https://doi.org/10.1016/j.colsurfa.2020.124962	journal	September 2020
Effect of surface decoration on properties and drug release ability of nanogels Pinelli, Filippo; Pizzetti, Fabio; Rossetti, Arianna Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 614 https://doi.org/10.1016/j.colsurfa.2021.126164	journal	April 2021
Design, characterization and in vitro evaluation of 5-aminosalicylic acid loaded N-succinyl-chitosan microparticles for colon specific delivery Mura, C.; Nácher, A.; Merino, V. Colloids and Surfaces B: Biointerfaces, Vol. 94 https://doi.org/10.1016/j.colsurfb.2012.01.030	journal	June 2012
Synthesis and characterization of an injectable microparticles integrated hydrogel composite biomaterial: In-vivo biocompatibility and inflammatory arthritis treatment Dhanka, Mukesh; Pawar, Vaishali; Chauhan, Deepak S. Colloids and Surfaces B: Biointerfaces, Vol. 201 https://doi.org/10.1016/j.colsurfb.2021.111597	journal	May 2021
E-drug delivery: a futuristic approach Yadav, Khushwant S.; Kapse-Mistry, Sonali; Peters, G. J. Drug Discovery Today, Vol. 24, Issue 4 https://doi.org/10.1016/j.drudis.2019.02.005	journal	April 2019
Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma Bessone, Carolina Del Valle; Akhlaghi, Seyedeh Parinaz; Tártara, Luis Ignacio European Journal of Pharmaceutical Sciences, Vol. 160 https://doi.org/10.1016/j.ejps.2021.105748	journal	May 2021
Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application Banerjee, Subham; Siddiqui, Lubna; Bhattacharya, Shiv Sankar International Journal of Biological Macromolecules, Vol. 50, Issue 1 https://doi.org/10.1016/j.ijbiomac.2011.10.020	journal	January 2012
Development of amphoteric alginate/aminated chitosan coated microbeads for oral protein delivery Omer, A. M.; Tamer, T. M.; Hassan, M. A. International Journal of Biological Macromolecules, Vol. 92 https://doi.org/10.1016/j.ijbiomac.2016.07.019	journal	November 2016
Magnetic nanocellulose alginate hydrogel beads as potential drug delivery system Supramaniam, Jagadeesen; Adnan, Rohana; Mohd Kaus, Noor Haida International Journal of Biological Macromolecules, Vol. 118 https://doi.org/10.1016/j.ijbiomac.2018.06.043	journal	October 2018
Synthesis and drug delivery properties of Ibuprofen-Cellulose nanofibril system Chen, Tiantian; He, Xinghua; Jiang, Tianyan International Journal of Biological Macromolecules, Vol. 182 https://doi.org/10.1016/j.ijbiomac.2021.04.096	journal	July 2021
pH- and electro-responsive characteristics of silk fibroin–hyaluronic acid polyelectrolyte complex membranes Malay, Özge; Batıgün, Ayşegül; Bayraktar, Oguz International Journal of Pharmaceutics, Vol. 380, Issue 1-2 https://doi.org/10.1016/j.ijpharm.2009.07.011	journal	October 2009
Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate] Wu, Wei; Liu, Jing; Cao, Shuqin International Journal of Pharmaceutics, Vol. 416, Issue 1 https://doi.org/10.1016/j.ijpharm.2011.06.015	journal	September 2011
In vitro controlled release of antihypertensive drugs intercalated into unmodified SBA-15 and MgO modified SBA-15 matrices Alexa, Iuliana Florentina; Ignat, Maria; Popovici, Roxana Florentina International Journal of Pharmaceutics, Vol. 436, Issue 1-2 https://doi.org/10.1016/j.ijpharm.2012.06.036	journal	October 2012
Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents Freitas, Emanuelle D.; Freitas, Vitória M. S.; Rosa, Paulo C. P. Materials Science and Engineering: C, Vol. 118 https://doi.org/10.1016/j.msec.2020.111412	journal	January 2021
Mesoporous silica nanoparticles in drug delivery and biomedical applications Wang, Ying; Zhao, Qinfu; Han, Ning Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 11, Issue 2 https://doi.org/10.1016/j.nano.2014.09.014	journal	February 2015
Controlled-release antihistamines using supercritical antisolvent process Franco, Paola; De Marco, Iolanda The Journal of Supercritical Fluids, Vol. 171 https://doi.org/10.1016/j.supflu.2021.105201	journal	May 2021
Construction of a Mesoporous Polydopamine@GO/Cellulose Nanofibril Composite Hydrogel with an Encapsulation Structure for Controllable Drug Release and Toxicity Shielding Liu, Yingying; Fan, Qing; Huo, Ying ACS Applied Materials & Interfaces, Vol. 12, Issue 51 https://doi.org/10.1021/acsami.0c15465	journal	December 2020
Nanocellulose/Gelatin Composite Cryogels for Controlled Drug Release Li, Jian; Wang, Yujia; Zhang, Lei ACS Sustainable Chemistry & Engineering, Vol. 7, Issue 6 https://doi.org/10.1021/acssuschemeng.9b00161	journal	February 2019
Synthesis and Cellular Uptake of Folic Acid-Conjugated Cellulose Nanocrystals for Cancer Targeting Dong, Shuping; Cho, Hyung Joon; Lee, Yong Woo Biomacromolecules, Vol. 15, Issue 5 https://doi.org/10.1021/bm401593n	journal	April 2014
Versatile Molding Process for Tough Cellulose Hydrogel Materials Kimura, Mutsumi; Shinohara, Yoshie; Takizawa, Junko Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep16266	journal	November 2015
Surface modification of cellulose nanocrystals Eyley, Samuel; Thielemans, Wim Nanoscale, Vol. 6, Issue 14 https://doi.org/10.1039/C4NR01756K	journal	January 2014
pH- and electro-response characteristics of bacterial cellulose nanofiber/sodium alginate hybrid hydrogels for dual controlled drug delivery Shi, Xiangning; Zheng, Yudong; Wang, Guojie RSC Adv., Vol. 4, Issue 87 https://doi.org/10.1039/C4RA09640A	journal	January 2014
The binary complex of poly(PEGMA-co-MAA) hydrogel and PLGA nanoparticles as a novel oral drug delivery system for ibuprofen delivery Shang, Qing; Huang, Sijin; Zhang, Aixin Journal of Biomaterials Science, Polymer Edition, Vol. 28, Issue 16 https://doi.org/10.1080/09205063.2017.1354677	journal	July 2017
Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis Chen, Wenlei; Zhi, Min; Feng, Zujian International Journal of Nanomedicine, Vol. Volume 14 https://doi.org/10.2147/IJN.S190781	journal	January 2019
Fabrication of Cellulose Nanocrystal/Chitosan Hydrogel for Controlled Drug Release Xu, Qinghua; Ji, Yunzhong; Sun, Qiucun Nanomaterials, Vol. 9, Issue 2 https://doi.org/10.3390/nano9020253	journal	February 2019

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