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Genetic mutations and mechanisms in dilated cardiomyopathy
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Two-State Model of Acto-Myosin Attachment-Detachment Predicts C-Process of Sinusoidal Analysis
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Drosophila muscle myosin heavy chain encoded by a single gene in a cluster of muscle mutations
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How Myosin Generates Force on Actin Filaments
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Dilated cardiomyopathy myosin mutants have reduced force-generating capacity
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Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster
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Three-dimensional structure of myosin subfragment-1: a molecular motor
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Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector
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Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene
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The Genetic Bases of Cardiomyopathies
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Alternative myosin hinge regions are utilized in a tissue-specific fashion that correlates with muscle contraction speed.
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Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo
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Two step mechanism of phosphate release and the mechanism of force generation in chemically skinned fibers of rabbit psoas muscle
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Characterisation of missense mutations in the Act88F gene of Drosophila melanogaster
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An exceptionally fast actomyosin reaction powers insect flight muscle
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Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy
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Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities
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Vinculin network–mediated cytoskeletal remodeling regulates contractile function in the aging heart
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The Structural Coupling between ATPase Activation and Recovery Stroke in the Myosin II Motor
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Alternative Exon-encoded Regions of Drosophila Myosin Heavy Chain Modulate ATPase Rates and Actin Sliding Velocity
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The structure of the rigor complex and its implications for the power stroke
- Holmes, K. C.; Trentham, D. R.; Simmons, R.
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Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 359, Issue 1452
https://doi.org/10.1098/rstb.2004.1566
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Small Molecules Acting on Myofilaments as Treatments for Heart and Skeletal Muscle Diseases
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Genetic Control of Heart Function and Aging in Drosophila
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Alterations of Myocardial Dynamic Stiffness Implicating Abnormal Crossbridge Function in Human Mitral Regurgitation Heart Failure
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January 2002 |
Aging Enhances Indirect Flight Muscle Fiber Performance yet Decreases Flight Ability in Drosophila
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Phosphorylation-dependent power output of transgenic flies: an integrated study
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Drosophila, an emerging model for cardiac disease
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Toward understanding actin activation of myosin ATPase: The role of myosin surface loops
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Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts
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Alternative S2 Hinge Regions of the Myosin Rod Differentially Affect Muscle Function, Myofibril Dimensions and Myosin Tail Length
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Myosin Transducer Mutations Differentially Affect Motor Function, Myofibril Structure, and the Performance of Skeletal and Cardiac Muscles
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Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy
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August 2018 |
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy
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April 2013 |
Functional Characterization of Human Myosin-18A and Its Interaction with F-actin and GOLPH3
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Age-dependent changes in proteins of Drosophila melanogaster
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A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila
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Kinetic Analysis of Drosophila Muscle Myosin Isoforms Suggests a Novel Mode of Mechanochemical Coupling
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Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments
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The role of super-relaxed myosin in skeletal and cardiac muscle
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Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions
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The actin-myosin interface
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Drosophila as a model to study cardiac aging
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Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain
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April 2013 |
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse α-cardiac myosin in the laser trap assay
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Role of MgATP and MgADP in the cross-bridge kinetics in chemically skinned rabbit psoas fibers. Study of a fast exponential process (C)
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Selectivity of protein oxidative damage during aging in Drosophila melanogaster
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Three-dimensional structure of vertebrate cardiac muscle myosin filaments
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Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases
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Kinetic Mechanism of Human Myosin IIIA
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Molecular and ultrastructural defects in a Drosophila myosin heavy chain mutant: differential effects on muscle function produced by similar thick filament abnormalities.
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Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function
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Mechanical analysis of Drosophila indirect flight and jump muscles
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Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan
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An optimized transgenesis system for Drosophila using germ-line-specific C31 integrases
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February 2007 |
Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system
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The BioCAT undulator beamline 18ID: a facility for biological non-crystalline diffraction and X-ray absorption spectroscopy at the Advanced Photon Source
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Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature
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In Vivo X-Ray Diffraction of Indirect Flight Muscle from Drosophila melanogaster
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The Genetic Basis for Cardiomyopathy
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