High-resolution multicontrast tomography with an X-ray microarray anode–structured target source

Zan, Guibin; Gul, Sheraz; Zhang, Jin; Zhao, Wei; Lewis, Sylvia; Vine, David J.; Liu, Yijin; Pianetta, Piero; Yun, Wenbing

doi:10.1073/pnas.2103126118

Title: High-resolution multicontrast tomography with an X-ray microarray anode–structured target source

Journal Article · Thu Jun 17 00:00:00 EDT 2021 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.2103126118· OSTI ID:1818469

Zan, Guibin ^[1]; Gul, Sheraz ^[2]; Zhang, Jin ^[1];

^[3]; Lewis, Sylvia ^[2]; Vine, David J. ^[2];

^[1]; Pianetta, Piero ^[1]; Yun, Wenbing ^[2]

SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)
Sigray Inc., Concord, CA (United States)
Beihang Univ., Beijing (China)

Multicontrast X-ray imaging with high resolution and sensitivity using Talbot–Lau interferometry (TLI) offers unique imaging capabilities that are important to a wide range of applications, including the study of morphological features with different physical properties in biological specimens. The conventional X-ray TLI approach relies on an absorption grating to create an array of micrometer-sized X-ray sources, posing numerous limitations, including technical challenges associated with grating fabrication for high-energy operations. We overcome these limitations by developing a TLI system with a microarray anode–structured target (MAAST) source. The MAAST features an array of precisely controlled microstructured metal inserts embedded in a diamond substrate. Using this TLI system, tomography of a Drum fish tooth with high resolution and tri-contrast (absorption, phase, and scattering) reveals useful complementary structural information that is inaccessible otherwise. The results highlight the exceptional capability of high-resolution multicontrast X-ray tomography empowered by the MAAST-based TLI method in biomedical applications.

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Research Organization:: SLAC National Accelerator Lab., Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-76SF00515; R44EB023284

OSTI ID:: 1818469

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 25; ISSN 0027-8424

Publisher:: National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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