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Office of Scientific and Technical Information
 

Sulfatides are endogenous ligands for the TLR4?MD-2 complex

Journal Article · · Proc. Natl. Acad. Sci. USA
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1818320
Journal Information:
Proc. Natl. Acad. Sci. USA, Vol. 118, Issue (30)
Country of Publication:
United States
Language:
ENGLISH

References (64)

The Structural Biology of Toll-like Receptors journal April 2011
Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation journal April 2018
Endogenous toll-like receptor ligands and their biological significance journal November 2010
The TLR4 antagonist Eritoran protects mice from lethal influenza infection journal May 2013
Recombinant Human Heat Shock Protein 60 Does Not Induce the Release of Tumor Necrosis Factor α from Murine Macrophages journal June 2003
Postulates for validating TLR4 agonists: Highlights journal January 2015
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice journal August 2018
TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS journal February 2016
Role of sulfatide in normal and pathological cells and tissues journal May 2012
Antibodies to sulfatide in cerebrospinal fluid of patients with multiple sclerosis journal June 2003
The Existence of Galactosylceramide I3-Sulfate in Serums of Various Mammals and Its Anticoagulant Activity1 journal August 1991
Lipid microarrays identify key mediators of autoimmune brain inflammation journal December 2005
Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction journal November 2014
Levels of plasma sulfatides C18 : 0 and C24 : 1 correlate with disease status in relapsing-remitting multiple sclerosis journal July 2013
Dendritic Cells and Anergic Type I NKT Cells Play a Crucial Role in Sulfatide-Mediated Immune Regulation in Experimental Autoimmune Encephalomyelitis journal June 2014
Prevention of Autoimmunity by Targeting a Distinct, Noninvariant CD1d-reactive T Cell Population Reactive to Sulfatide journal March 2004
Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis: Sulfatide deficiency and ceramide elevation in AD journal August 2002
Involvement of sulfatide in beta cells and type 1 and type 2 diabetes journal September 2005
Treatment with Sulfatide or its Precursor, Galactosylceramide, Prevents Diabetes in NOD Mice journal January 2001
Sulfatides trigger cytokine gene expression and secretion in human monocytes journal August 1994
Synthetic isoforms of endogenous sulfatides differently modulate indoleamine 2,3-dioxygenase in antigen presenting cells journal August 2011
Intervention in endotoxin shock by sulfatide (I3SO3-GalCer) with a concomitant reduction in tumor necrosis factor alpha production journal April 1997
Sulfatide, A Major Lipid Component of Myelin Sheath, Activates Inflammatory Responses As an Endogenous Stimulator in Brain-Resident Immune Cells journal November 2008
Self-Glycolipids Modulate Dendritic Cells Changing the Cytokine Profiles of Committed Autoreactive T Cells journal December 2012
Sulfatide Inhibits HMGB1 Secretion by Hindering Toll-Like Receptor 4 Localization Within Lipid Rafts journal June 2020
Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer journal January 2017
Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14 journal January 1994
MyD88: a central player in innate immune signaling journal November 2014
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway journal August 2003
LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins journal April 2004
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. journal April 1996
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2 journal April 2012
Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy journal October 2014
The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex journal March 2009
Crystal Structures of Human MD-2 and Its Complex with Antiendotoxic Lipid IVa journal June 2007
Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran journal September 2007
Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations journal November 2010
TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide journal March 2013
Globo-series glycosphingolipids enhance Toll-like receptor 4-mediated inflammation and play a pathophysiological role in diabetic nephropathy journal December 2018
MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation journal March 2010
The long and the short of ceramides journal June 2018
Mammalian ceramide synthases journal January 2010
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides journal August 2005
The ins and outs of sphingolipid synthesis journal June 2005
Quantitative imaging mass spectrometry of renal sulfatides: validation by classical mass spectrometric methods journal November 2014
Sulfatide is a negative regulator of oligodendrocyte differentiation: Development in sulfatide-null mice journal January 2004
Chemistry and functional distribution of sulfoglycolipids journal December 1997
Expression of the myelin and oligodendrocyte progenitor marker sulfatide in neurons and astrocytes of adult rat brain journal June 2002
Intracellular sulfatide expression in a subpopulation of astrocytes in primary cultures journal June 1998
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers journal August 2009
Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography-tandem mass spectrometry journal April 2015
Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4 journal May 2019
Role of CREB in modulation of TNFα and IL-10 expression in LPS-stimulated RAW264.7 macrophages journal April 2010
Linearization of the Bradford Protein Assay Increases Its Sensitivity: Theoretical and Experimental Studies journal May 1996
HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes journal July 2006
Likelihood-enhanced fast translation functions journal March 2005
Coot model-building tools for molecular graphics journal November 2004
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Comparison of simple potential functions for simulating liquid water journal July 1983
Development and testing of a general amber force field journal January 2004
Automatic atom type and bond type perception in molecular mechanical calculations journal October 2006
New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations journal March 1999
Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim journal March 2019
End-Point Binding Free Energy Calculation with MM/PBSA and MM/GBSA: Strategies and Applications in Drug Design journal June 2019

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